We report new Yb-doped gain fibers with approximately 20-μm core diameter and 400-μm cladding. These fibers have mode-field diameter greater than 19 μm, and increased higher-order-mode loss compared to conventional 19-μm modefield diameter fibers. The increased higher-order mode loss allows for high transverse-mode instability thresholds in fibers that also have large MFD and high absorption. A 21-μm fiber with 6.5 m operating length, was free from transverse-modal instabilities at 3.6 kW signal power and had 81% optical-optical efficiency. In narrow-linewidth amplifier experiments, the next-generation fiber with 21 μm fiber achieved 2.74 kW output power at 6 GHz linewidth, limited by pump power. This represents almost 2x increase in the ratio of power to signal linewidth compared to existing commercially available 19.5 μm MFD fibers, achieving 510 kW/GHz.
In this preclinical study we demonstrated that treatment with repetitive magnetic stimulation (RMS) protects the epithelial layer in a rabbit model of exposure keratopathy, preventing loss of the epithelial cells and maintaining the function of the corneal barrier under extreme desiccation conditions. A single 15 minutes RMS treatment supported corneal barrier integrity under acute desiccation for 3 months. AS-OCT imaging and histopathology analysis demonstrated the safety of RMS treatment. Our study suggests that repetitive magnetic stimulation may present a novel treatment for protection of corneal epithelium in patients with DES, and may alleviate DES symptoms.
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