Here, we established NpHR Drosophila model, and demonstrated a heartbeat recovery process after red-light excitation induced cardiac arrest. The maximum heart rate (maxHR) and heart rate recovery time increased with prolonged cardiac arrest. ReaChR fly model was also developed to study the relationship of maximum pace-able heart rate (maxPR) with aging. Older flies showed decreased maxPR. An optical coherence microscopy (OCM) system was used to monitor the heart rate in vivo and in real time. The maxHR, recovery time, and maxPR could become promising indicators of cardiac health for various cardiac studies via Drosophila models in future.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.