Raman and fluorescence spectroscopic characterization of pteridines in the blood of normal subjects and oral cancer patients

Elumalai Brindha; Ramu Rajasekaran; Ganesan Bharanidharan; Biniyam Girma Manaye; Prakasarao Aruna; Singaravelu Ganesan

doi:10.1117/12.3010048

12 March 2024 Raman and fluorescence spectroscopic characterization of pteridines in the blood of normal subjects and oral cancer patients

Elumalai Brindha, Ramu Rajasekaran, Ganesan Bharanidharan, Biniyam Girma Manaye, Prakasarao Aruna, Singaravelu Ganesan

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Proceedings Volume 12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 128360I (2024) https://doi.org/10.1117/12.3010048
Event: SPIE BiOS, 2024, San Francisco, California, United States

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Abstract

Pteridines and its derivatives are considered as important cofactors participating in cellular metabolism. Studies reported that, the distribution of pteridines and its derivatives may change when monocytes and macrophages are activated under interferon- γ stimulus by cancer. Also, there is a significant variation in the concentration and conformation of pteridines under different pathological conditions. It has been reported that during the transformation of normal cells into neoplasm, the metabolic end products of the cancer cells are released into the blood, thereby changing the components and contents of the biological molecules and their local environment. In this regard, the present study is aimed to characterize pteridines and its derivatives in the blood plasma of normal subjects and patients with confirmed oral cancer using fluorescence and Raman spectroscopy. Observed Fluorescence & Raman spectral characteristics of samples and subsequent discriminant analysis predicts that 75 % of the original and cross validated groups are correctly classified.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Elumalai Brindha, Ramu Rajasekaran, Ganesan Bharanidharan, Biniyam Girma Manaye, Prakasarao Aruna, and Singaravelu Ganesan "Raman and fluorescence spectroscopic characterization of pteridines in the blood of normal subjects and oral cancer patients", Proc. SPIE 12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 128360I (12 March 2024); https://doi.org/10.1117/12.3010048

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