Laser, gamma irradiation, and chemotherapy in treatment of experimental tumors sensitized by porphyrins

Konstantinas Povilas Valuckas; Janina Didziapetriene; Vydmantas Atkocius; Laima Griciute; Zivile Luksiene; Laima Zaleckaite; Ricardas Rotomskis; Valerijus Smilgevicius

doi:10.1117/12.146297

18 June 1993 Laser, gamma irradiation, and chemotherapy in treatment of experimental tumors sensitized by porphyrins

Konstantinas Povilas Valuckas, Janina Didziapetriene, Vydmantas Atkocius, Laima Griciute, Zivile Luksiene, Laima Zaleckaite, Ricardas Rotomskis, Valerijus Smilgevicius

Author Affiliations +

Proceedings Volume 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II; (1993) https://doi.org/10.1117/12.146297
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The new hematoporphyrin derivatives--HpD-1 and dimethoxyhematoporphyrin--DMHp were studied. Their physico-chemical properties, activity in tumor PDT and influence on therapeutic effect of tumor radiation therapy and on toxicity of chemotherapeutic agents were investigated. Hematoporphyrin--Hp was used as control. Data, obtained by absorption spectroscopy, indicated that HpD-1 and DMHp strongly aggregates in aqueous solution and HpD-1 has many covalently bound structures. HpD-1 and DMHp effects in tumor PDT and radiation therapy were studied using 8 species of transplantable tumors. The sensitizers were injected to the animals intraperitoneally in a dosage of 5 - 20 mg/kg. In 48-76 hours after sensitizers were injected, the tumors were irradiated by the pulsed Raman laser pumped by the SHG of YAG:Nd³⁺ laser. The parameters of this laser system are as follows: the wavelength 630 nm, the pulse duration (tau) equals 1 ns, energy E equals 10 mJ, the repetition rate f equals 10 Hz, average power P equals 100 mW. The goal of our investigation was to attempt to optimize tumor radiation therapy and chemotherapy.

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Konstantinas Povilas Valuckas, Janina Didziapetriene, Vydmantas Atkocius, Laima Griciute, Zivile Luksiene, Laima Zaleckaite, Ricardas Rotomskis, and Valerijus Smilgevicius "Laser, gamma irradiation, and chemotherapy in treatment of experimental tumors sensitized by porphyrins", Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); https://doi.org/10.1117/12.146297

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