Photo-oxidative stability of various tetra-azaporphyrin derivatives in solution and correlation with semiempirical MO calculations

Guenter Schnurpfeil; Abdol Khezer Sobbi; Ulrike Michelsen; Dieter Woehrle

doi:10.1117/12.297818

29 December 1997 Photo-oxidative stability of various tetra-azaporphyrin derivatives in solution and correlation with semiempirical MO calculations

Guenter Schnurpfeil, Abdol Khezer Sobbi, Ulrike Michelsen, Dieter Woehrle

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297818
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

For the application of photosensitizers in PDT attention must be given to the stability of these compounds. For various substituted and annelated tetraazaporphyrins zinc complexes the experimentally determined first order rate constant of the photo-oxidative decomposition in DMF were compared with the calculated values of the HOMO energy level. The method described allows one to predict the photo-oxidative stability by calculating their HOMO levels which is important for the use of macrocyclic metal complexes in the photodynamic therapy of cancer. To high photo-oxidative stability leads to risks in healthy tissues and reduces photodynamic effects in tumor tissues. To low photo-oxidative stability cause problems in preparation, purification and in vivo persistency of photosensitizers for tumor treatment.

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Guenter Schnurpfeil, Abdol Khezer Sobbi, Ulrike Michelsen, and Dieter Woehrle "Photo-oxidative stability of various tetra-azaporphyrin derivatives in solution and correlation with semiempirical MO calculations", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297818

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