Noise-band factor analysis of cancer Fourier transform infrared evanescent-wave fiber optical (FTIR-FEW) spectra

Sydney Sukuta; Reinhard F. Bruch

doi:10.1117/12.465246

1 May 2002 Noise-band factor analysis of cancer Fourier transform infrared evanescent-wave fiber optical (FTIR-FEW) spectra

Sydney Sukuta, Reinhard F. Bruch

Author Affiliations +

Proceedings Volume 4613, Optical Biopsy IV; (2002) https://doi.org/10.1117/12.465246
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The goal of this study is to test the feasibility of using noise factor/eigenvector bands as general clinical analytical tools for diagnoses. We developed a new technique, Noise Band Factor Cluster Analysis (NBFCA), to diagnose benign tumors via their Fourier transform IR fiber optic evanescent wave spectral data for the first time. The middle IR region of human normal skin tissue and benign and melanoma tumors, were analyzed using this new diagnostic technique. Our results are not in full-agreement with pathological classifications hence there is a possibility that our approaches could complement or improve these traditional classification schemes. Moreover, the use of NBFCA make it much easier to delineate class boundaries hence this method provides results with much higher certainty.

Citation Download Citation

Sydney Sukuta and Reinhard F. Bruch "Noise-band factor analysis of cancer Fourier transform infrared evanescent-wave fiber optical (FTIR-FEW) spectra", Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); https://doi.org/10.1117/12.465246

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