Integrated optical coupling element for functional genomic analysis biosensor

Corinne Vergnenegre; Charlotte Bringer; Veronique Bardinal; Thierry Camps; Chantal Fontaine; Antonio Munoz-Yague

doi:10.1117/12.513289

18 February 2004 Integrated optical coupling element for functional genomic analysis biosensor

Corinne Vergnenegre, Charlotte Bringer, Veronique Bardinal, Thierry Camps, Chantal Fontaine, Antonio Munoz-Yague

Proceedings Volume 5249, Optical Design and Engineering; (2004) https://doi.org/10.1117/12.513289
Event: Optical Systems Design, 2003, St. Etienne, France

Abstract

We present here a design of a coupling element aimed to be integrated into a nanomechanical biosensor for functional genomic analysis. The operation principle is based on a sub-nanometer resolution optical measurement of a cantilever deflection caused by a surface stress when the target nucleic acid sample hybridizes to the nucleic acid probe on the active side of the cantilever. The resulting deflection, of the order of nanometers, is measured by an optical system, in which a laser beam reflects off the back of the cantilever to a position sensitive photo-detector. We study in this paper three polymer optical coupling systems which could allow to detect the presence of target nucleic acid on the cantilever by amplifying the deflection caused by the stress.

Citation Download Citation

Corinne Vergnenegre, Charlotte Bringer, Veronique Bardinal, Thierry Camps, Chantal Fontaine, and Antonio Munoz-Yague "Integrated optical coupling element for functional genomic analysis biosensor", Proc. SPIE 5249, Optical Design and Engineering, (18 February 2004); https://doi.org/10.1117/12.513289

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