Integrated optical detection subsystem for functional genomic analysis biosensor

Corinne Vergnenègre; Thierry Camps; Véronique Bardinal; Charlotte Bringer; Chantal Fontaine; Antonio Muñoz-Yagüe

doi:10.1117/12.628297

12 October 2005 Integrated optical detection subsystem for functional genomic analysis biosensor

Corinne Vergnenègre, Thierry Camps, Véronique Bardinal, Charlotte Bringer, Chantal Fontaine, Antonio Muñoz-Yagüe

Proceedings Volume 5969, Photonic Applications in Biosensing and Imaging; 596912 (2005) https://doi.org/10.1117/12.628297
Event: Photonics North, 2005, Toronto, Canada

Abstract

We present an optical microsystem aimed to be integrated into a nanomechanical biosensor for functional genomic analysis. The operation principle is based on a sub-nanometer resolution optical measurement of a cantilever deflection caused by a surface stress when the target nucleic acid sample hybridises to the nucleic acid probe on the active side of the cantilever. The resulting deflection, of the order of nanometers, is measured by an optical system, in which a laser beam reflects off the back of the cantilever to a position sensitive photo-detector. We report in this paper on the design, fabrication and test of the optical head associated with an optical coupling system which enables detection of the presence of target nucleic acid on the cantilever by amplifying the deflection caused by the stress.

Citation Download Citation

Corinne Vergnenègre, Thierry Camps, Véronique Bardinal, Charlotte Bringer, Chantal Fontaine, and Antonio Muñoz-Yagüe "Integrated optical detection subsystem for functional genomic analysis biosensor", Proc. SPIE 5969, Photonic Applications in Biosensing and Imaging, 596912 (12 October 2005); https://doi.org/10.1117/12.628297

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