Development of an intravascular laser treatment with an infrared free electron laser

Sachiko Suzuki-Yoshihashi; Katsunori Ishii; Tomoko Sano; Kunio Awazu

doi:10.1117/12.591912

15 April 2005 Development of an intravascular laser treatment with an infrared free electron laser

Sachiko Suzuki-Yoshihashi, Katsunori Ishii, Tomoko Sano, Kunio Awazu

Proceedings Volume 5695, Optical Interactions with Tissue and Cells XVI; (2005) https://doi.org/10.1117/12.591912
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

A cholesterol ester is selective dissociated by MIR-FEL irradiation with wavelength of 5.75 μm correspond to C=O stretching vibration of ester bond. To evaluate the optimum irradiation condition for cholesterol ester decomposition without normal endothelium cell damage, we perform a 5.75 μm-FEL irradiation to a two-layer vessel model which is cholesterol oleate as a model of atherosclerotic lesions and gelatin as a model of endothelial cells. The ester decomposition and gelatin damege depends on total power density of 5.75 μm-FEL provided the two-layer model. Exposure of the FEL with power density exceed 17.8 W/cm² decomposed cholesterol ester thorough gelain layer of 15 μm thickness. If FEL with power density of 25.0 W/cm² is exposed during 10 seconds, the gelatin is evaporized. Therefore, the optimum condition for ester decomposition without gelatin evaporation is between 75 J/cm² from 20 J/cm² in the case of 15 μm gelatin layer thickness. The maximum ester decomposition rate without gelatin vaporization is 71% on FEL of power density of 17.8 W/cm² for 10 seconds.

Citation Download Citation

Sachiko Suzuki-Yoshihashi, Katsunori Ishii, Tomoko Sano, and Kunio Awazu "Development of an intravascular laser treatment with an infrared free electron laser", Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); https://doi.org/10.1117/12.591912

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