Tracing and quantification of pharmaceuticals using MR imaging and spectroscopy at clinical MRI system

Eun-Kee Jeong; Xin Liu; Xianfeng Shi; Y. Bruce Yu; Zeng-Rong Lu

doi:10.1117/12.1000015

24 October 2012 Tracing and quantification of pharmaceuticals using MR imaging and spectroscopy at clinical MRI system

Eun-Kee Jeong, Xin Liu, Xianfeng Shi, Y. Bruce Yu, Zeng-Rong Lu

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Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 854845 (2012) https://doi.org/10.1117/12.1000015
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

Magnetic resonance imaging (MRI) and spectroscopy (MRS) is very powerful modality for imaging and localized investigation of biological tissue. Medical MRI measures nuclear magnetization of the water protons, which consists of 70 % of our body. MRI provides superior contrast among different soft tissues to all other existing medical imaging modalities, including ultrasound, X-ray CT, PET, and SPECT. In principle, MRI/S may be an ideal non-invasive tool for drug delivery research. However, because of its low sensitivity, a large dose is required for tracing pharmaceuticals. Therefore, its use for imaging of pharmaceuticals is very limited mostly to molecules that contain a paramagnetic metal ion, such as gadolinium (Gd³⁺) and manganese (Mn²⁺). The paramagnetic metal ion provides a large fluctuating magnetic field at the proton in the water molecule via a coordinate site. The measurement of local drug concentration is the first step for further quantification. Local concentration of the paramagnetic-ion based MRI contrast agent can be indirectly measured via the change in the water signal intensity. ¹⁹F MRI/S of fluorinated complex may be an option for drug delivery and tracing agent, because the fluorinated molecule may be directly detected due to its large magnetic moment (94 % of proton) and 100 % abundance.

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Eun-Kee Jeong, Xin Liu, Xianfeng Shi, Y. Bruce Yu, and Zeng-Rong Lu "Tracing and quantification of pharmaceuticals using MR imaging and spectroscopy at clinical MRI system", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854845 (24 October 2012); https://doi.org/10.1117/12.1000015

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