Laser fluorescence spectrometers for medical diagnosis

Miroslaw Kwasny; Zygmunt Mierczyk

doi:10.1117/12.405956

2 November 2000 Laser fluorescence spectrometers for medical diagnosis

Miroslaw Kwasny, Zygmunt Mierczyk

Proceedings Volume 4238, Laser Technology VI: Applications; (2000) https://doi.org/10.1117/12.405956
Event: Laser Technology VI, 1999, Szczecin, Poland

Abstract

The paper presents fibre fluorescence analysers for in vivo examined biological tissues. The systems devoted to clinical investigations are equipped with laser excitation sources; He-Cd (442 nm), Nd:YAG (II and III harmonic: 532 and 355 nm, respectively) and He-Ne (632.8 nm). They allow non-invasive determination of endogenous fluorophones level in any organs as well as monitoring of external sensitisers level when photodynamic method of diagnosis and treatment of tumors is used. Selection of various wavelengths within the range of porphyrines, excitation depends on different light penetration in various tissues. For the tumors localised under mucous membrane, UV, violet, and blue radiation was used for excitation and for deeply localised tumors, a radiation of longer wavelengths (green and red) was used. The carried out clinical examinations showed usefulness of fluorometric systems for diagnostics of skin diseases, gynaecological spheres, and pneumopathies. These analysers can be also applied for environmental protection, food control, and industrial processes monitoring.

Citation Download Citation

Miroslaw Kwasny and Zygmunt Mierczyk "Laser fluorescence spectrometers for medical diagnosis", Proc. SPIE 4238, Laser Technology VI: Applications, (2 November 2000); https://doi.org/10.1117/12.405956

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