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Proceedings Article

Ultrahigh-velocity resolution imaging of the microcirculation in-vivo using color Doppler optical coherence tomography

[+] Author Affiliations
Siavash Yazdanfar, Andrew M. Rollins, Joseph A. Izatt

Case Western Reserve Univ. (USA)

Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, 156 (May 23, 2001); doi:10.1117/12.427887
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From Conference Volume 4251

  • Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V
  • Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto
  • San Jose, CA | January 20, 2001

abstract

Color Doppler optical coherence tomography (CDOCT) is a method for noninvasive cross-sectional imaging of blood flow in vivo. In previous implementations, velocity estimates were obtained by measuring the frequency shift of discrete depth-resolved backscatter spectra, resulting in a velocity resolution on the order of 1 mm/s. We present a novel processing method that detects Doppler shifts calculated across sequential axial scans, enabling ultrahigh velocity resolution (~1 micron/s) flow measurement in scattering media. This method of sequential scan processing was calibrated with a moving mirror mounted on a precision motorized translator. Latex microspheres suspended in deuterium oxide were used as a highly scattering test phantom. Laminar flow profiles down to ~15 micron/s centerline velocity (0.02 cc/hr) were observed with a sensitivity of 1.2 micron/s. Finally, vessels on the order of 10 microns in diameter were imaged in living human skin, with a relative frequency sensitivity less than 4 x 10-5. To our knowledge, these results are the lowest velocities ever measured with CDOCT.

© (2001) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Siavash Yazdanfar ; Andrew M. Rollins and Joseph A. Izatt
"Ultrahigh-velocity resolution imaging of the microcirculation in-vivo using color Doppler optical coherence tomography", Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, 156 (May 23, 2001); doi:10.1117/12.427887; http://dx.doi.org/10.1117/12.427887


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