Building artificial networks of neuronal cells with light-assisted polymer surface functionalization

Dan V. Nicolau; Hideo Taniguchi; Takahisa Taguchi; Susumu Yoshikawa

doi:10.1117/12.293501

14 November 1997 Building artificial networks of neuronal cells with light-assisted polymer surface functionalization

Dan V. Nicolau, Hideo Taniguchi, Takahisa Taguchi, Susumu Yoshikawa

Proceedings Volume 3241, Smart Materials, Structures, and Integrated Systems; (1997) https://doi.org/10.1117/12.293501
Event: Far East and Pacific Rim Symposium on Smart Materials, Structures, and MEMS, 1997, Adelaide, Australia

Abstract

The surface of photosensible diazo-naphto-quinone/novolak film was chemically manipulated through UV exposure and subsequent functionalization processes to obtain surfaces with different chemistries (DNQ, carboxylic, and peptidic groups). The neuronal cell attachment is controlled by three pairs of antagonistic surface variables: charged/uncharged species, amino/carboxylic groups and hydrophilic/hydrophobic balance, in which the former promote the adhesion. The study proves that microlithographic techniques in connection with surface functionalization with specific neuro-peptides can be used to build artificial networks with neuronal cells.

Citation Download Citation

Dan V. Nicolau, Hideo Taniguchi, Takahisa Taguchi, and Susumu Yoshikawa "Building artificial networks of neuronal cells with light-assisted polymer surface functionalization", Proc. SPIE 3241, Smart Materials, Structures, and Integrated Systems, (14 November 1997); https://doi.org/10.1117/12.293501

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