Dr. Chao Kang Liao Profile

Dr. Chao Kang Liao

Deputy Technical Director at Imec Taiwan Co

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Author

Publications (11)

Proceedings Article | 6 March 2014 Paper

Human machine interface by using stereo-based depth extraction

Chao-Kang Liao, Chi-Hao Wu, Hsueh-Yi Lin, Ting-Ting Chang, Tung-Yang Lin, Po-Kuan Huang

Proceedings Volume 9013, 90130C (2014) https://doi.org/10.1117/12.2038782

KEYWORDS: Cameras, Image processing, Field programmable gate arrays, Light sources and illumination, 3D image processing, Imaging systems, Infrared cameras, Control systems, Sensors, Gesture recognition

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Proceedings Article | 4 March 2014 Paper

Lens-free digital in-line holographic imaging for wide field-of-view, high-resolution and real-time monitoring of complex microscopic objects

Richard Stahl, Geert Vanmeerbeeck, Gauthier Lafruit, Roeland Huys, Veerle Reumers, Andy Lambrechts, Chao-Kang Liao, Chin-Chun Hsiao, Masayuki Yashiro, Masashi Takemoto, Tomohisa Nagata, Shinichi Gomi, Kunitada Hatabayashi, Yasuhiro Oshima, Shigenori Ozaki, Naoki Nishishita, Shin Kawamata

Proceedings Volume 8947, 89471F (2014) https://doi.org/10.1117/12.2037619

KEYWORDS: Imaging systems, Prototyping, Image resolution, Microscopes, Holography, Digital holography, Image sensors, Inspection, Microscopy, Image quality

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Proceedings Article | 25 February 2012 Paper

Towards a real-time high-definition depth sensor with hardware-efficient stereo matching

Ke Zhang, Guanyu Yi, C.-K. Liao, Christine Lin, Hsiu-Chi Yeh, Rudy Lauwereins, Luc Van Gool, Gauthier Lafruit

Proceedings Volume 8288, 82882K (2012) https://doi.org/10.1117/12.906574

KEYWORDS: Computer programming, Field programmable gate arrays, Sensors, Optimization (mathematics), Parallel computing, Prototyping, Detection and tracking algorithms, Radio propagation, Cameras, Structured light

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Proceedings Article | 11 March 2008 Paper

In vivo photoacoustic imaging with multiple selective targeting using bioconjugated gold nanorods

Chen-Wei Wei, Chao-Kang Liao, Ying-Yi Chen, Churng-Ren Chris Wang, Ann-Ann Ding, Dar-Bin Shiehd, Pai-Chi Li

Proceedings Volume 6856, 68560J (2008) https://doi.org/10.1117/12.764454

KEYWORDS: Gold, Tumors, Cancer, Nanoprobes, In vivo imaging, Absorption, Photoacoustic imaging, Target detection, Photoacoustic spectroscopy, Nanorods

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Proceedings Article | 28 February 2008 Paper

Photoacoustic wave propagation simulations using the FDTD method with Berenger's perfectly matched layers

Yae-Lin Sheu, Chen-Wei Wei, Chao-Kang Liao, Pai-Chi Li

Proceedings Volume 6856, 685619 (2008) https://doi.org/10.1117/12.764416

KEYWORDS: Photoacoustic spectroscopy, Finite-difference time-domain method, Wave propagation, Biomedical optics, Error analysis, Absorption, Laser irradiation, Acoustics, Computer simulations, Signal attenuation

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SPIE Journal Paper | 1 November 2007 Open Access

Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system

Chao-Kang Liao, Sheng-Wen Huang, Chen-Wei Wei, Pai-Chi Li

JBO, Vol. 12, Issue 06, 064006, (November 2007) https://doi.org/10.1117/12.10.1117/1.2812704

KEYWORDS: Gold, Photoacoustic imaging, Photoacoustic spectroscopy, Imaging systems, Toxic industrial chemicals, Transducers, Biological research, Absorption, Ultrasonography, Nanorods

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Proceedings Article | 13 February 2007 Paper

Quantitative reconstruction of optical absorption coefficient in backward mode photoacoustic imaging

Chao-Kang Liao, Pai-Chi Li

Proceedings Volume 6437, 64371W (2007) https://doi.org/10.1117/12.701725

KEYWORDS: Absorption, Photoacoustic spectroscopy, Reconstruction algorithms, Photoacoustic imaging, Acoustics, Tissue optics, Transducers, Laser irradiation, Biomedical optics, Tomography

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Proceedings Article | 6 March 2006 Paper

Multiple targeting in photoacoustic imaging using bioconjugated gold nanorods

Pai-Chi Li, Chen-Wei Wei, Chao-Kang Liao, Cheng-Dah Chen, Kuei-Chen Pao, Churng-Ren Chris Wang, Ya-Na Wu, Dar-Bin Shieh

Proceedings Volume 6086, 60860M (2006) https://doi.org/10.1117/12.645248

KEYWORDS: Gold, Absorption, Nanoparticles, Proteins, Cancer, Photoacoustic spectroscopy, Molecules, Nanoprobes, Photoacoustic imaging, Nanorods

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Cancer cells presented altered surface molecules to encourage their growth and metastasis. Expression of oncogeneic surface molecules also play important roles in the prediction of clinical outcome and treatment response of anti-cancer drugs. It is thus conceivable that imaging of cancer lesions while simultaneously obtaining their pathogenic information at molecular level of as many oncogenic proteins as possible is of great clinical significance. Gold nanoparticles have been used as a contrast agent for photoacoustic imaging. In addition, gold nanoparticles can be bioconjugated to probe certain molecular processes. An intriguing property of gold nanoparticles is its ability to tailor its optical properties. For example, size effects on the surface plasmon absorption of spherical gold nanoparticles have shown that the peak optical absorption red-shifts with the increasing particle size. In addition, the optical absorption spectrum of cylindrical gold nanoparticles (i.e., gold nanorods) exhibits a strong absorption band that is directly related to the aspect ratio. With these unique characteristics, selective targeting can be achieved in photoacoustic molecular imaging. Specifically, gold nanorods with different aspect ratios can be bioconjugated to different antibodies. Multiple targeting and simultaneous detection can then be achieved by using laser irradiation at the respective peak optical absorption wavelength. In this study, photoacoustic multiple targeting using gold nanorods is experimentally demonstrated. We have chosen Her2 and CXCR4 as our primary target molecule as Her2 expression is associated with growth characteristics and sensitivity to Herceptin chemotherapy. On the other hand, CXCR4 expression predict the organ-specific metastatic potential of the cancer cells for clinical intervention in advance. Monoclonal antibody (mAb) against Her2/neu was conjugated to nanorods with several different aspect ratios. The agarose gel is suitable for photoacoustic signal acquisition. A wavelength tunable Ti-Sapphire laser was used for laser irradiation and a 1 MHz ultrasound transducer was used for acoustic detection. The optical wavelength of the laser was tuned between 800 nm and 940 nm, corresponding to gold nanorods of an aspect ratio ranging from 3.7 to 5.9. The results clearly show the potential of photoacoustic molecular imaging with multiple targeting in revealing different oncogene expression levels of the cancer cells.

Proceedings Article | 6 March 2006 Paper

A high frame rate photoacoustic imaging system and its applications to perfusion measurements

Chao-Kang Liao, Sheng-Wen Huang, Chen-Wei Wei, Pai-Chi Li

Proceedings Volume 6086, 60860S (2006) https://doi.org/10.1117/12.646196

KEYWORDS: Photoacoustic spectroscopy, Imaging systems, Gold, Photoacoustic imaging, Laser energy, Toxic industrial chemicals, Ultrasonography, Transducers, Data acquisition, Nanorods

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Proceedings Article | 25 April 2005 Paper

Optoacoustic imaging with improved synthetic focusing

Chao-Kang Liao, Meng-Lin Li, Pai-Chi Li

Proceedings Volume 5697, (2005) https://doi.org/10.1117/12.591052

KEYWORDS: Signal to noise ratio, Transducers, Scattering, Tissue optics, Biomedical optics, Ultrasonography, Acoustics, Image resolution, Image quality, Tissues

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Proceedings Article | 25 April 2005 Paper

Time-intensity based optoacoustic flow measurements with gold nanoparticles

Pai-Chi Li, Chen-Wei Wei, Chao-Kang Liao, Hsiao-Chien Tseng, Yen-Ping Lin, Chia-Chun Chen

Proceedings Volume 5697, (2005) https://doi.org/10.1117/12.591106

KEYWORDS: Nanoparticles, Gold, Toxic industrial chemicals, Imaging systems, Blood circulation, Ultrasonography, Absorption, Nd:YAG lasers, Ultrasonics, Transducers

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Showing 5 of 11 publications

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