Dr. Haiying Cheng Profile

Dr. Haiying Cheng

at Emory Univ

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Proceedings Article | 17 February 2009 Paper

Laser speckle imaging of rat retinal blood flow with hybrid temporal and spatial analysis method

Haiying Cheng, Yumei Yan, Timothy Duong

Proceedings Volume 7163, 716304 (2009) https://doi.org/10.1117/12.809906

KEYWORDS: Speckle, Blood circulation, Signal to noise ratio, Spatial resolution, Statistical analysis, Laser speckle imaging, Oxygen, Spatial analysis, Image resolution, Doppler effect

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Noninvasive monitoring of blood flow in retinal circulation will reveal the progression and treatment of ocular disorders, such as diabetic retinopathy, age-related macular degeneration and glaucoma. A non-invasive and direct BF measurement technique with high spatial-temporal resolution is needed for retinal imaging. Laser speckle imaging (LSI) is such a method. Currently, there are two analysis methods for LSI: spatial statistics LSI (SS-LSI) and temporal statistical LSI (TS-LSI). Comparing these two analysis methods, SS-LSI has higher signal to noise ratio (SNR) and TSLSI is less susceptible to artifacts from stationary speckle. We proposed a hybrid temporal and spatial analysis method (HTS-LSI) to measure the retinal blood flow. Gas challenge experiment was performed and images were analyzed by HTS-LSI. Results showed that HTS-LSI can not only remove the stationary speckle but also increase the SNR. Under 100% O2, retinal BF decreased by 20-30%. This was consistent with the results observed with laser Doppler technique. As retinal blood flow is a critical physiological parameter and its perturbation has been implicated in the early stages of many retinal diseases, HTS-LSI will be an efficient method in early detection of retina diseases.

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