Ms. Kirstin Engelking Profile

Kirstin Engelking

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Proceedings Article | 13 July 2004 Paper

Clinical results of photodynamic therapy for the treatment of sarcoid tumors in equids

Scott Gustafson, Kirstin Engelking, Steven Jacques, Robert Bildfell

Proceedings Volume 5312, (2004) https://doi.org/10.1117/12.528079

KEYWORDS: Tumors, Photodynamic therapy, Tissues, Biopsy, Light emitting diodes, Semiconductor lasers, Light sources, Gas lasers, Ear, Surgery

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Sarcoids are a locally invasive cutaneous fibroblastic neoplasia and are the most common skin tumor of equids. Myriad treatments are described in the literature including surgery, topical blistering agents, cryosurgery, immunotherapy, and intralesional chemotherapy. Recurrence or progression of the disease after treatment is common. Two years ago the authors began clinical trials investigating the feasibility of photodynamic therapy for the treatment of sarcoid tumors. The tumor or surgical margins were treated using topical or intra-lesional delta-aminolevulinic acid (ALA) as a photosensitizing agent. The ALA was left in situ for a period of time allowing buildup of protoporphyrin IX (the photosensitizer) prior to irradiation with a 635-nm diode laser. We have initial results in 10 patients with 18 lesions and have seen decrease in tumor size or complete remission in 13 of 18 lesions. Recurrence or progression has been noted in 7 lesions. Results of these trials and follow-up information on clinical patients will be presented for review.

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