Prof. Tarl W. Prow Profile

Prof. Tarl W. Prow

Research Professor at Univ of South Australia

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Author

Publications (13)

Proceedings Article | 19 April 2017 Presentation

Combining imaging with microbiopsy enables a more comprehensive approach for topical drug research (Conference Presentation)

Tarl Prow

Proceedings Volume 10046, 1004608 (2017) https://doi.org/10.1117/12.2256642

KEYWORDS: Skin, Confocal microscopy, Luminescence, Confocal fluorescent microscopy, Image analysis, Visualization, Tissues, Current controlled current source

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Proceedings Article | 19 April 2017 Presentation

Advanced imaging approaches for characterizing nanoparticle delivery and dispersion in skin (Conference Presentation)

Tarl Prow, Miko Yamada, Nhung Dang, Conor Evans

Proceedings Volume 10046, 1004607 (2017) https://doi.org/10.1117/12.2256789

KEYWORDS: Photomedicine, Current controlled current source, Nanoparticles, Skin, CARS tomography, Visualization, Microscopy, Silica, Coating, Tissues

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Proceedings Article | 8 December 2016 Paper

Optical feedback effects on terahertz quantum cascade lasers: modelling and applications

Aleksandar Rakić, Yah Leng Lim, Thomas Taimre, Gary Agnew, Xiaoqiong Qi, Karl Bertling, She Han, Stephen Wilson, Iman Kundu, Andrew Grier, Zoran Ikonić, Alexander Valavanis, Aleksandar Demić, James Keeley, Lianhe Li, Edmund Linfield, A. Giles Davies, Paul Harrison, Blake Ferguson, Graeme Walker, Tarl Prow, Dragan Indjin, H. Peter Soyer

Proceedings Volume 10030, 1003016 (2016) https://doi.org/10.1117/12.2250621

KEYWORDS: Quantum cascade lasers, Terahertz radiation, Tissues, Imaging systems, Melanoma, Reflectivity, Modulation, Skin, Mouse models, Modeling

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Proceedings Article | 27 April 2016 Paper

Diffuse reflectance imaging for non-melanoma skin cancer detection using laser feedback interferometry

Alireza Mowla, Thomas Taimre, Yah Lim, Karl Bertling, Stephen Wilson, Tarl Prow, H. Soyer, Aleksandar Rakić

Proceedings Volume 9887, 98870T (2016) https://doi.org/10.1117/12.2227449

KEYWORDS: Laser interferometry, Skin cancer, Interferometry, Skin, Tissues, Laser tissue interaction, Laser imaging, Infrared lasers, Vertical cavity surface emitting lasers, Scattering, Tumors, Tissue optics, Monte Carlo methods, Absorption, Optical properties

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Proceedings Article | 20 March 2015 Paper

Segmentation of skin strata in reflectance confocal microscopy depth stacks

Samuel Hames, Marco Ardigò, H. Peter Soyer, Andrew Bradley, Tarl Prow

Proceedings Volume 9413, 94131U (2015) https://doi.org/10.1117/12.2081737

KEYWORDS: Skin, Confocal microscopy, Reflectivity, Image segmentation, Associative arrays, Visualization, Tissue optics, Dermatology, Spherical lenses, Medical imaging

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SPIE Journal Paper | 3 July 2013 Open Access

Feasibility of multiphoton microscopy-based quantification of antibiotic uptake into neutrophil granulocytes

Adnan Mahmood, Jeffrey Grice, Michael Roberts, Tarl Prow

JBO, Vol. 18, Issue 07, 076003, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.7.076003

KEYWORDS: Multiphoton microscopy, Blood, Luminescence, Image analysis, Scanning probe microscopy, Molecules, Sensors, Confocal microscopy, Microscopy, Bacteria

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SPIE Journal Paper | 27 November 2012 Open Access

Background free imaging of upconversion nanoparticle distribution in human skin

Zhen Song, Yuri Anissimov, Jiangbo Zhao, Andrei Nechaev, Annemarie Nadort, Dayong Jin, Tarl Prow, Michael Roberts, Andrei Zvyagin

JBO, Vol. 18, Issue 06, 061215, (November 2012) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.061215

KEYWORDS: Skin, Nanoparticles, Upconversion, Tissue optics, Ytterbium, Diffusion, Luminescence, Tissues, Thulium, Nanomaterials

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SPIE Journal Paper | 1 July 2010 Open Access

Analysis of the metabolic deterioration of ex vivo skin from ischemic necrosis through the imaging of intracellular NAD(P)H by multiphoton tomography and fluorescence lifetime imaging microscopy

Washington Sanchez, Tarl Prow, Jeffrey Grice, Michael Roberts

JBO, Vol. 15, Issue 04, 046008, (July 2010) https://doi.org/10.1117/12.10.1117/1.3466580

KEYWORDS: Skin, Luminescence, Fluorescence lifetime imaging, Picosecond phenomena, In vivo imaging, Tissues, Image quality, Photon counting, Oxygen, Biological research

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Proceedings Article | 10 February 2007 Paper

Multifunctional nanoparticles for drug/gene delivery in nanomedicine

Mary-Margaret Seale, Dimitry Zemlyanov, Christy Cooper, Emily Haglund, Tarl Prow, Lisa Reece, James Leary

Proceedings Volume 6447, 64470E (2007) https://doi.org/10.1117/12.701645

KEYWORDS: Nanoparticles, Iron, Oxides, Molecules, Multilayers, Magnetism, Manufacturing, Nanomedicine, Cancer, Particles

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Proceedings Article | 1 April 2005 Paper

Biosensor-controlled gene therapy/drug delivery with nanoparticles for nanomedicine

Tarl Prow, William Rose, Nan Wang, Lisa Reece, Yuri Lvov, James Leary

Proceedings Volume 5692, (2005) https://doi.org/10.1117/12.589422

KEYWORDS: Nanoparticles, Molecules, Nanomedicine, Biosensors, Multilayers, Neptunium, Particles, Cancer, Manufacturing, Cell death

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Proceedings Article | 1 July 2004 Paper

Nanomedicine: nanoparticles, molecular biosensors, and targeted gene/drug delivery for combined single-cell diagnostics and therapeutics

Tarl Prow, Jose Salazar, William Rose, Jacob Smith, Lisa Reece, Andrea Fontenot, Nan Wang, R. Stephen Lloyd, James Leary

Proceedings Volume 5318, (2004) https://doi.org/10.1117/12.547922

KEYWORDS: Nanoparticles, Molecules, Nanomedicine, Biosensors, Cell death, Diagnostics and therapeutics, Medicine, Diagnostics, In vitro testing, Nanocrystals

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Proceedings Article | 4 June 2002 Paper

Importance of high-throughput cell separation technologies for genomics/proteomics-based clinical diagnostics

James Leary, Peter Szaniszlo, Tarl Prow, Lisa Reece, Nan Wang, David Asmuth

Proceedings Volume 4625, (2002) https://doi.org/10.1117/12.469773

KEYWORDS: Blood, Magnetism, Statistical analysis, Diagnostics, Proteins, Tissues, Biomedical optics, Modulation, Flow cytometry, Logic

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Gene expression microarray analyses of mixtures of cells approximate a weighted average of the gene expression profiles (GEPs) of each cell type according to its relative abundance in the overall cell sample being analyzed. If the targeted subpopulation of cells is in the minority, or the expected perturbations are marginal, then such changes will be masked by the GEP of the normal/unaffected cells. We show that the GEP of a minor cell subpopulation is often lost when that cell subpopulation is of a frequency less than 30 percent. The GEP is almost always masked by the other cell subpopulations when that frequency drops to 10 percent or less. Several methodologies can be employed to enrich the target cells submitted for microarray analyses. These include magnetic sorting and laser capture microdissection. However, high-throughput flow cytometry/cell sorting overcomes many restrictions of experimental enrichment conditions. This technology can also be used to sort smaller numbers of cells of specific cell subpopulations and subsequently amplify their mRNAs before microarray analyses. When purification techniques are applied to unfixed samples, the potential for changes in gene levels during the process of collection is an additional concern. High-throughput cell separation technologies are needed that can process the necessary number of cells expeditiously in order to avoid such uncontrolled changes in the target cells GEP. In cases where even the use of HTS yields only a small number of cells, the mRNAs (after reverse transcription to cDNA's) must be amplified to yield enough material for conventional microarray analyses. However, the problem of using microamplification PCR methods to expand the amount of cDNAs (from mRNAs) is that it is very difficult to amplify equally all of the mRNAs. Unequal amplification leads to a distorted gene expression profile on the microarray. Linear amplifications is difficult to achieve. Unfortunately, present-day gene-chips need to be about 100 times more sensitive than they are now to be able to do many biologically and biomedically meaningful experiments and clinical tests.

Proceedings Article | 22 May 2001 Paper

High-throughput cell analysis and sorting technologies for clinical diagnostics and therapeutics

James Leary, Lisa Reece, Peter Szaniszlo, Tarl Prow, Nan Wang

Proceedings Volume 4255, (2001) https://doi.org/10.1117/12.426754

KEYWORDS: Tumors, Blood, Diagnostics, Pathogens, Luminescence, Diagnostics and therapeutics, Flow cytometry, Energy transfer, Breast cancer, Fetus

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Showing 5 of 13 publications

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