Dr. Thien Nguyen Profile

Dr. Thien Nguyen

at National Institutes of Health

SPIE Involvement:

Author

Proceedings Article | 13 March 2024 Presentation

Observing the influence of gas concentration in intracellular dynamic activity using label-free optical imaging

Soongho Park, Varun Gunda, Thien Nguyen, Jinho Park, Amir Gandjbakhche

Proceedings Volume PC12840, PC128400I (2024) https://doi.org/10.1117/12.3001123

KEYWORDS: Oxygen, Optical imaging, Vacuum chambers, Biotechnology, Biological samples, Scattering, Organisms, Optical coherence tomography, Mode conditioning cables, Medicine

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Proceedings Article | 13 March 2024 Presentation

Deep-learning-based breathing pattern classification method for real-time monitoring of patients with infectious respiratory disease

Jinho Park, Thien Nguyen, Amir Gandjbakhche

Proceedings Volume PC12838, PC1283803 (2024) https://doi.org/10.1117/12.3003602

KEYWORDS: Image classification, Pulmonary disorders, Near infrared spectroscopy, Nervous system, Hemodynamics, Feature extraction, Data modeling, COVID 19, Algorithm development, Lung

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Proceedings Article | 13 March 2024 Presentation

A point-of-care multimodal biosensor for continuous and remote monitoring of physiological signs in patients with infectious respiratory diseases

Thien Nguyen, Soongho Park, Amir Gandjbakhche

Proceedings Volume PC12838, PC128380C (2024) https://doi.org/10.1117/12.3000078

KEYWORDS: Wearable devices, Pulmonary disorders, Point-of-care devices, Oxygen, Biosensors, Tissues, Temperature metrology, Near infrared spectroscopy, Blood oxygen saturation, Temperature sensors

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Proceedings Article | 6 March 2023 Presentation

Investigation of the potential of a multimodal biosensor in screening and monitoring infections respiratory diseases

Vinay Veluvolu, Thien Nguyen, Soongho Park, Amir Gandjbakhche

Proceedings Volume PC12375, PC123750C (2023) https://doi.org/10.1117/12.2663641

KEYWORDS: Pulmonary disorders, Biosensors, Tissues, Data modeling, Oxygen, Near infrared spectroscopy, Brain, Blood, Vital signs, Temperature sensors

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Proceedings Article | 6 March 2023 Presentation

Monitoring of fetal heart rate using near-infrared spectroscopy

Thien Nguyen, Sooongho Park, Dahiana Gallo, Tomi Kanninen, Zeyu Zhang, George Downey, Roberto Romero, Amir Gandjbakhche

Proceedings Volume PC12375, PC123750B (2023) https://doi.org/10.1117/12.2661534

KEYWORDS: Fetus, Heart, Near infrared spectroscopy, Ultrasonography, Doppler effect, Signal detection, Electronic filtering, Sensors, Medicine, Light sources

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Proceedings Article | 6 March 2023 Presentation

COVID-19 patient monitoring system using wearable NIRS device and deep learning algorithm

Jinho Park, Amir Gandjbakhche, Soongho Park, Thien Nguyen

Proceedings Volume PC12375, PC123750A (2023) https://doi.org/10.1117/12.2661522

KEYWORDS: Near infrared spectroscopy, Tissue optics, Sensors, Lung, Light emitting diodes, Algorithm development, Tissues, Image classification, Hypoxia

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Proceedings Article | 6 March 2023 Presentation

Multiwavelength based approach to calculate tissue oxygen saturation using near-infrared spectroscopy

Thien Nguyen, Soongho Park, Brian Hill, Amir Gandjbakhche

Proceedings Volume PC12375, PC1237508 (2023) https://doi.org/10.1117/12.2661535

KEYWORDS: Near infrared spectroscopy, Tissues, Tissue optics, Near infrared, Oxygen, Spectroscopy, Oximetry, Monte Carlo methods, Light sources, Spectroscopes

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Proceedings Article | 7 March 2022 Poster + Presentation

Quantitative evaluation of dynamic activity of HeLa cells using dynamic full-field optical coherence microscopy: viable and dead cells

Soongho Park, Thien Nguyen, Amir Gandjbakhche

Proceedings Volume PC11964, PC119640I (2022) https://doi.org/10.1117/12.2610456

KEYWORDS: Optical coherence microscopy, Motion analysis, Image analysis, Cytoskeletons, Cell death, Biological research

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Proceedings Article | 7 March 2022 Presentation

A wearable NIRS device to monitor in-vivo placental oxygenation levels in the placenta with and without lesions

Thien Nguyen, Kosar Khaksari, Soongho Park, Amir Gandjbakhche

Proceedings Volume PC11956, PC119560E (2022) https://doi.org/10.1117/12.2610026

KEYWORDS: Near infrared spectroscopy, In vivo imaging, Fetus, Tissues, Tissue optics, Ultrasonography, Pathology, Oxygen, Inspection, Hypoxia

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SPIE Journal Paper | 25 March 2021 Open Access

Review of the efficacy of infrared thermography for screening infectious diseases with applications to COVID-19

Kosar Khaksari, Thien Nguyen, Brian Hill, John Perrault, Viswanath Gorti, Emily Blick, Tomas Gonzalez Cano, Babak Shadgan, Timothy Quang, Ravi Malpani, Amir Gandjbakhche

JMI, Vol. 8, Issue S1, 010901, (March 2021) https://doi.org/10.1117/12.10.1117/1.JMI.8.S1.010901

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Proceedings Article | 5 March 2021 Poster + Presentation

Non-destructive elastic properties measurement using 3×3 fiber-optic coupler based interferometric quadrature detection

Soongho Park, Thien Nguyen, Amir Gandjbakhche

Proceedings Volume 11642, 1164242 (2021) https://doi.org/10.1117/12.2582791

KEYWORDS: Nondestructive evaluation, Interferometry, Fiber optics, Fiber optics tests, Interferometers, Phase shifts, Acoustics, Wave propagation, Ultrasonics, Transducers

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Proceedings Article | 5 March 2021 Presentation

Oxygenation measurement of placenta tissue during pregnancy using near infrared spectroscopy

Thien Nguyen, Kosar Khaksari, Siddharth Khare, Roberto Romero, Amir Gandjbakhche

Proceedings Volume 11638, 1163804 (2021) https://doi.org/10.1117/12.2582790

KEYWORDS: Near infrared spectroscopy, Fetus, Tissue optics, Tissues, Uterus, Ultrasonography, Skin, Scattering, Oxygen, Monte Carlo methods

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Proceedings Article | 5 March 2021 Presentation

Study of the mirror neuron network through functional connectivity

Thien Nguyen, Helga Miguel, Amir Gandjbakhche

Proceedings Volume 11629, 116291H (2021) https://doi.org/10.1117/12.2582788

KEYWORDS: Neurons, Mirrors, Brain, Near infrared spectroscopy, Hemodynamics, Cognition

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SPIE Journal Paper | 5 November 2020 Open Access

Evaluation of the human placenta optical scattering properties using continuous wave and frequency-domain diffuse reflectance spectroscopy

Siddharth Khare, Thien Nguyen, Afrouz Anderson, Brian Hill, Roberto Romero, Amir Gandjbakhche

JBO, Vol. 25, Issue 11, 116001, (November 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.11.116001

KEYWORDS: Scattering, Tissue optics, Fetus, Near infrared spectroscopy, Diffuse reflectance spectroscopy, Blood, Tissues, Light scattering, Absorption, Optical properties

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Significance: Placenta is an essential organ for fetal development and successful reproduction. Placental insufficiency can lead to fetal hypoxia and, in extreme cases anoxia, leading to fetal death. Of the 145 million deliveries per year worldwide, ∼15 million neonates are small for gestational age and, therefore, at risk for antepartum and intrapartum hypoxia. Clinical methods to assess placental function largely rely on the assessment of fetal heart rate changes but do not assess placental oxygenation. Near-infrared spectroscopy (NIRS) allows non-invasive, real-time assessment of tissue oxygenation in intact organs, which can be used to assess placental oxygenation. However, tissue optical properties can affect the accuracy of methods to measure tissue oxygenation. Aim: This study was performed to estimate the scattering coefficient of the human placenta. We have computed the scattering coefficients of the human placenta for the range of 659 to 840 nm using two methods of diffuse reflectance spectroscopy (DRS). Approach: Measurements were performed using an in-house DRS device and a well-established frequency-domain diffuse optical spectroscopic system (DOSI). Measurements were performed in eight placentas obtained after cesarean deliveries. Placentas were perfused with normal saline to minimize the effects of absorption due to blood. Three sites per placenta were measured. Absorption and scattering coefficients were then calculated from the measured reflectance using the random walk theory for DRS and frequency-domain algorithm for DOSI. Results: Average reduced scattering coefficient (μs ′ ) was 0.943 ± 0.015 mm − 1 at 760 nm and 0.831 ± 0.009 mm − 1 at 840 nm, and a power function μs ′ = 1.6619 (λ/500 nm) − 1.426 was derived for the human placental scattering coefficient. Conclusion: We report for the first time the scattering coefficient of the human placenta. This information can be used to assess baseline scattering and improve measurements of placental oxygen saturation with NIRS.

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Showing 5 of 14 publications

Conference Committee Involvement (1)

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables VI

25 January 2025 | San Francisco, California, United States

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