CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12842 > Article
Presentation
13 March 2024 Biodegradable polymersomes with encapsulated indocyanine green J-aggregates for highly selective photoacoustic cancer imaging
Mohammed Kawelah, Sangheon Han, Ceren Dincer, Aasim Hussain, Alexander Marras, Thomas Truskett, Konstantin Sokolov, Keith Johnston
Author Affiliations +
Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128421A (2024) https://doi.org/10.1117/12.3002660
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Photoacoustic imaging (PAI) has started to emerge in clinics for cancer care from early detection to therapy monitoring. Herein, we encapsulate indocyanine green J-aggregates (ICGJ), an FDA-approved NIR contrast agent, into biodegradable polymersomes (ICGJ-Ps) with high loading for strong photoacoustic signals. The small Ps hydrodynamic diameter of 80-90nm is beneficial for the ability to penetrate tumors and for uptake in cancer cells. The high ICGJ loadings up to ~40% produce strong photoacoustic (PA) signals. Conjugation of ICGJ-Ps with cetuximab antibodies produced PA signals in breast cancer cells that correlated well with their inherent EGFR expression levels indicating exceptional specificity.
Conference Presentation
© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Mohammed Kawelah, Sangheon Han, Ceren Dincer, Aasim Hussain, Alexander Marras, Thomas Truskett, Konstantin Sokolov, and Keith Johnston "Biodegradable polymersomes with encapsulated indocyanine green J-aggregates for highly selective photoacoustic cancer imaging", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128421A (13 March 2024); https://doi.org/10.1117/12.3002660
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Polymers
Cancer
Indocyanine green
Photoacoustic imaging
Cancer detection
Photoacoustic spectroscopy
Tumors
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top