Photoacoustic imaging (PAI) has started to emerge in clinics for cancer care from early detection to therapy monitoring. Herein, we encapsulate indocyanine green J-aggregates (ICGJ), an FDA-approved NIR contrast agent, into biodegradable polymersomes (ICGJ-Ps) with high loading for strong photoacoustic signals. The small Ps hydrodynamic diameter of 80-90nm is beneficial for the ability to penetrate tumors and for uptake in cancer cells. The high ICGJ loadings up to ~40% produce strong photoacoustic (PA) signals. Conjugation of ICGJ-Ps with cetuximab antibodies produced PA signals in breast cancer cells that correlated well with their inherent EGFR expression levels indicating exceptional specificity.
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