A new candidate agent for fluorescence-guided neurosurgery produces high, persistent tumor contrast shortly after administration

Augustino V. Scorzo; Brook K. Byrd; Rendall R. Strawbridge; Scott C. Davis

doi:10.1117/12.2650599

14 March 2023 A new candidate agent for fluorescence-guided neurosurgery produces high, persistent tumor contrast shortly after administration

Augustino V. Scorzo, Brook K. Byrd, Rendall R. Strawbridge, Scott C. Davis

Author Affiliations +

Proceedings Volume 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; 1236106 (2023) https://doi.org/10.1117/12.2650599
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Neurosurgical fluorescence guidance relies on contrast agents to identify tumor regions to aid in increasing the extent of resection. Existing contrast agents for this indication each have their own limitation: unpredictable contrast from tumor heterogeneity, significant extravasation into the background brain and long incubation times. An ideal contrast agent should have high and rapid contrast that persists well into the surgical procedure. By using a whole animal hyperspectral cryo-imaging system several CAs were screened for these favorable properties and compared to the gold standard of gadolinium enhanced MR. Herein, we briefly report on the leading candidate Rd-PEG1k, which shows high contrast within minutes of administration that persists for at least 90 minutes.

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Citation Download Citation

Augustino V. Scorzo, Brook K. Byrd, Rendall R. Strawbridge, and Scott C. Davis "A new candidate agent for fluorescence-guided neurosurgery produces high, persistent tumor contrast shortly after administration", Proc. SPIE 12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, 1236106 (14 March 2023); https://doi.org/10.1117/12.2650599

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