Evaluation of multiple fluorescent agents and intraoperative MRI in a novel pig glioma model for fluorescence guided neurosurgery

Caleb Y. Kwon; Augustino V. Scorzo; Rendall R. Strawbridge; Ryan B. Duke; William R. Warner; Kristen L. Chen; Chengpei Li; Xiaoyao Fan; David W. Roberts; Keith D. Paulsen; Scott C. Davis

doi:10.1117/12.3005564

12 March 2024 Evaluation of multiple fluorescent agents and intraoperative MRI in a novel pig glioma model for fluorescence guided neurosurgery

Caleb Y. Kwon, Augustino V. Scorzo, Rendall R. Strawbridge, Ryan B. Duke, William R. Warner, Kristen L. Chen, Chengpei Li, Xiaoyao Fan, David W. Roberts, Keith D. Paulsen, Scott C. Davis

Author Affiliations +

Proceedings Volume 12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; 128250E (2024) https://doi.org/10.1117/12.3005564
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Pre-operative MRI with gadolinium-based contrast agents (Gd-MRI) is a central feature in surgical planning and intra-surgical navigation of glioma, yet brain movement during the surgical procedure can degrade the accuracy of these pre-operative images. Fluorescence guided neurosurgery is a technique which can complement MRI guidance by providing direct visualization of the tumor during surgery, and several agents either used routinely or under clinical development have shown effective tumor discrimination and impact on surgical outcomes. We have built a multi-spectral kinetic imaging system to acquire behavior of fluorophores overtime in animal models. Here, we exhibit this fluorescence kinetic imaging system and report its performance with tissue-simulating phantoms with multiple fluorophores. Also reported is our first experience with multiple fluorescent contrast agents in a novel oncopig model.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Caleb Y. Kwon, Augustino V. Scorzo, Rendall R. Strawbridge, Ryan B. Duke, William R. Warner, Kristen L. Chen, Chengpei Li, Xiaoyao Fan, David W. Roberts, Keith D. Paulsen, and Scott C. Davis "Evaluation of multiple fluorescent agents and intraoperative MRI in a novel pig glioma model for fluorescence guided neurosurgery", Proc. SPIE 12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, 128250E (12 March 2024); https://doi.org/10.1117/12.3005564

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