Ex vivo imaging of human pathologies with integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)

Chao Zhou; Aaron D. Aguirre; Yihong Wang; Bradley Bryan; Tsung-Han Tsai; James L. Connolly; James G. Fujimoto

doi:10.1117/12.809064

20 February 2009 Ex vivo imaging of human pathologies with integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)

Chao Zhou, Aaron D. Aguirre, Yihong Wang, Bradley Bryan, Tsung-Han Tsai, James L. Connolly, James G. Fujimoto

Author Affiliations +

Proceedings Volume 7168, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII; 71680N (2009) https://doi.org/10.1117/12.809064
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We report an imaging study using integrated 3D-OCT and OCM for the assessment of various human thyroid and breast pathologies. The 3D-OCT data sets enable en face projection imaging, which provides large field of view with uniform focus and signal level, while OCM provides high magnification that enables cellular resolution imaging. We have demonstrated that the integrated 3D-OCT and OCM technology provide a substantial improvement over standard OCT for the visualization of tissue pathology and can serve as a useful imaging tool in the clinical settings.

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Chao Zhou, Aaron D. Aguirre, Yihong Wang, Bradley Bryan, Tsung-Han Tsai, James L. Connolly, and James G. Fujimoto "Ex vivo imaging of human pathologies with integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)", Proc. SPIE 7168, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII, 71680N (20 February 2009); https://doi.org/10.1117/12.809064

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KEYWORDS

Optical coherence tomography

Tissues

Breast

Pathology

Image resolution

Cancer

Coherence (optics)

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