In order to improve the health and safety of the warfighter by bringing clinical diagnostic capabilities into the field, the Applied Research Laboratory and The Materials Research Institute at Penn State University are developing BIRDE, the Biothreat Identification using Raman Diagnostic Evaluation system. BIRDE is a field portable, reusable diagnostic system designed to provide the warfighter a highly specific assessment of pathogens (i.e. viruses, bacteria, bio threats) present in saliva, nasal washes, aerosols, and wastewater. BIRDE utilizes a microfluidic carbon nanotube (CNT) device for non-destructive, label-free capture of pathogens, coupled to a Surface Enhanced Raman Spectroscopy (SERS) sensor for biomarker interrogation and identification. Spectra collected from the captured pathogens are analyzed using advanced machine learning approaches, including deep learning networks, to provide highly accurate biomarker identification. The full process can be completed in minutes, providing critical information in a SWaP friendly configuration designed to keep up with the warfighter’s quickly changing environment.
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