Mr. Anqing Chen Profile

Anqing Chen

at Nanchang Univ

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Publications (3)

Proceedings Article | 22 March 2021 Poster + Paper

Simulation of Gaussian-beam photothermal effect of gastric tumor based on COMSOL

Xianlin Song, Anqing Chen, Jianshuang Wei

Proceedings Volume 11593, 1159333 (2021) https://doi.org/10.1117/12.2590883

KEYWORDS: Photoacoustic microscopy, Image fusion, Tissue optics, Focus stacking, 3D photoacoustic microscopy, Photoacoustic spectroscopy, Microscopes, Ultrasonics, Tissues, Skull

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Proceedings Article | 5 March 2021 Poster + Paper

Deconvolution optical-resolution photoacoustic microscope for high-resolution imaging of cerebral vasculature

Xianlin Song, Lingfang Song, Anqing Chen, Jianshuang Wei, Aojie Zhao, Ao Teng

Proceedings Volume 11649, 116491B (2021) https://doi.org/10.1117/12.2588860

KEYWORDS: Deconvolution, Photoacoustic spectroscopy, Image resolution, Tissues, Point spread functions, Photoacoustic imaging, Microscopes, Photoacoustic microscopy, Light scattering, Signal processing

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Photoacoustic imaging is becoming a very promising tool for the research of living organisms. It combines the high contrast of optical imaging and the high resolution of acoustic imaging to realize the imaging of absorption clusters in biological tissues. Since the scattering of ultrasound signals in biological tissues is 2-3 orders of magnitude weaker than the scattering of light in biological tissues, the endogenous absorption difference of tissues is directly used in the imaging process, so photoacoustic imaging has the advantages of deep imaging depth and non-destructive. As an important branch of photoacoustic imaging, photoacoustic microscopy can provide micron-level or even sub-micron-level imaging resolution, which is of great significance for biological research such as blood vessel detection. Since the lateral resolution of the photoacoustic microscopy imaging system depends on the focus of the laser, a higher resolution can be obtained by increasing the numerical aperture of the condenser objective. However, a large numerical aperture usually means a shorter working distance and makes the entire imaging system very sensitive to small optical defects. Therefore, the improvement of resolution through this method will be limited in practical applications. This paper implements a method of using iterative deconvolution to obtain a high-resolution photoacoustic image of the brain. The focal spot of the photoacoustic microscopy is measured to obtain the lateral PSF (point spread function) of the system. Making the measured PSF as the initial system PSF to perform Lucy- Richardson (LR) deconvolution. The image resolution of cerebral vasculature obtained by this method is higher. The full width at half maximum (FWHM) of width of the same cerebral capillaries before and after deconvolution are 7 μm and 3.6 μm, respectively, and the image definition is increased by about 1.9 times. Experiments show that this method can further improve the clarity of photoacoustic images of cerebral capillaries, which lays the foundation for further research on brain imaging.

Proceedings Article | 8 November 2020 Poster + Paper

Deconvolution optical-resolution photoacoustic microscope for high-resolution imaging of brain

Xianlin Song, Lingfang Song, Anqing Chen, Jianshuang Wei

Proceedings Volume 11525, 115252N (2020) https://doi.org/10.1117/12.2584875

KEYWORDS: Compressed sensing, Photoacoustic tomography, Photoacoustic imaging, Photoacoustic spectroscopy, Virtual reality, Data storage, Computer simulations, Biomedical optics, Reconstruction algorithms, Nondestructive evaluation

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