In imaging studies of neonates, particularly in the clinical setting, diusion tensor imaging-based tractography is
typically unreliable due to the use of fast acquisition protocols that yield low resolution and signal-to-noise ratio
(SNR). These image acquisition protocols are implemented with the aim of reducing displacement artifacts that
may be produced by the movement of the neonate's head during the scanning session. In addition, axons are not
yet fully myelinated in these subjects. As a result, the water molecules' movements are not as constrained as in
older brains, making it even more dicult to dene structure by means of diusion proles. Here, we introduce
a post-processing method that overcomes some of the diculties described above, allowing the determination of
reliable tracts in newborns. We test our method using neonatal data and in particular, we successfully extract
some of the limbic, association and commissural bers, all of which are typically dicult to obtain by direct
tractography. The method is further validated through visual inspection by expert pediatric neuroradiologists.
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