Reconstructed depth-resolved optic axis orientation obtained by catheter based PSOCT in a tissue volume informs on the orientation of the white matter fiber bundles in the brain, owing to the birefringence of myelinated axons. The physical organization of white matter also leads to anisotropic diffusion of water molecules, which is the basis of dMRI for non-invasive imaging of the three-dimensional orientation of white matter fiber bundles. Having access to fiber orientation in both imaging modalities, we are trying to map the depth-resolved birefringence and optic axis orientation to the larger scale dMRI as well as an atlas of brain anatomy.
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