We present a model based on Mie Surface Double Interaction (MSDI) to explore bead-based detection mechanisms
using imaging and scanning. The application goal of this work is to explore the trade-offs between the sensitivity and
throughput among various detection methods. Experimentally we use thermal oxide on silicon to establish and control
surface interferometric conditions. Surface-captured gold beads are detected using Molecular Interferometric Imaging
(MI2) and Spinning-Disc Interferometry (SDI).
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