Optical coherence tomography can provide visualizations of the eye both in diagnostic and surgical settings. However, noise limits the achievable image quality, especially in scenarios in which multi-frame averaging is not available. In this work, we present high-quality OCT image denoising using deep learning, only requiring unpaired volumetric capture scans for training. It is shown that, by exploiting neighboring B-scans, an artificial neural network for denoising OCT images can be trained based on a state-of-the-art approach which usually requires repeated scans from the exact same location. The effect of denoising is demonstrated for B-scans and volumetric renderings during and after mock cataract surgery on ex-vivo porcine eyes.
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