Lesion count is a key outcome to assess disease progression and the efficacy of new treatments for mpox. Accurately counting the hundreds to thousands of skin lesions typical of clade I mpox in endemic areas poses considerable human resource challenges. To document lesion appearance, evolution, and resolution during the PALM007 randomized controlled clinical trial of tecovirimat for mpox, we established smartphone-based protocols for standardized total body photography at remote sites in the Democratic Republic of the Congo. The trial is supported by the Institut National de la Recherche Biomédicale, NIAID, and funded by NCI Contract No.75N910D00024, Task Order No.75N91020F00025.
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