Cutaneous vascular malformations (CVM), such as port wine stain (PWS), often appear in highly visible parts of patient and cause emotional and social problems. In this work, we utilized our novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which combines nanosecond duration laser pulses synchronized with ultrasound bursts to treat blood vessels. The feasibility of PUT in the treatment of cutaneous microvessels was evaluated in a chicken wattle model in vivo. The treatment results showed perfusion stop in microvessels up to 1.5mm deep in chicken wattle, as demonstrated by both the OCT angiography and the color change in skin images after the treatment. The treatment effect and safety such as epidermal tissue damage and inflammation were also evaluated by H&E histology.
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