Age-related retinal diseases lead to blindness due to progressive loss of image-capturing photoreceptor neural cells, which are responsible for the conversion of light entering the eye into electrical signals that are sent to the brain. Retinitis pigmentosa and age-related macular degeneration are two leading causes of severe visual losses in adult individuals, affecting over 1 million people worldwide. In these diseases, rod and cone photoreceptor cells are progressively lost while neural cells in the retinal network remain functional. Electronic retinal prostheses have great potential to restore sight by electrical stimulation of the surviving neurons.
In this project, we aim at developing an artificial retinal implant based on organic photodetectors (OPDs). Neural stimulation is provided by an OPD pixel array processed on ultrathin plastic foil. Upon illumination with near-infrared (NIR) light, photo-generated electrical charge in each OPD pixel is delivered to the biological tissue via stimulating electrodes. Flexibility and softness of organic materials allow to interface intimately with neurons so that electrical signals generated by the implant are translated into bio-signals.
Firstly, we investigated the photovoltaic performance of NIR-sensitive OPDs based on polymer:fullerene bulk heterojunction. We used PDPP3T:PCBM photoactive layer to detect NIR light up to 930 nm. We showed that by going from a single to a tandem OPD the open-circuit voltage can be doubled and the charge threshold for neural stimulation can be reached at lower light intensities. This results in a more efficient cellular stimulation while maintaining high implant resolution.
Furthermore, we analysed the stimulating electrode behavior in a biological-like environment. We characterized the double-layer capacitance of gold, platinum and titanium nitrite (TiN) electrodes by pulsed-voltage measurements in phosphate buffered saline solution (PBS). We observed that TiN exhibits the highest charge capacitance due to the high surface roughness, which enables to maximize the charge injection into the electrolyte.
Using a combination of experimental work and modeling we studied the process of charge injection into the biological tissue. We simulated the injected charge during 1 ms NIR light pulse under different illumination conditions. We compared the performance of retinal implants based on single or tandem OPD pixels coupled to 20 µm stimulating electrodes. As we expected, tandem OPD pixels always maximize charge injection into the electrolyte due to their higher photo-voltage. Moreover, the high double-layer capacitance of TiN electrodes metal electrodes results in sufficient charge injection levels for neural stimulation, which is generally achieved between 1 and 4 nC.
In conclusion, we predicted that neural activity can be triggered using organic photovoltaic pixels in combination with high charge capacitance electrode materials. These findings are paving way to the development of a high-resolution retinal prostheses based on organic soft materials.
Diodes containing a layer of aluminum oxide combined with a layer of π-conjugated polymer show nonvolatile memory
effects after they have been electroformed. Electroforming is induced by application high bias voltage close to the limit
for dielectric breakdown and can be performed reliably and with high yield on organic-inorganic hybrid diodes with
controlled oxide thickness. Here we investigate the initial stage of the electroforming process and show through
temperature dependent current-voltage characterization that electrons are trapped in deep traps at the interface between
π-conjugated polyspirofluorene polymer and the aluminum oxide.
Monte Carlo simulations are used to investigate the dissociation of a Coulomb correlated charge pair at an idealized interface between an electron accepting and an electron donating molecular material. In the simulations the materials are represented by cubic lattices of sites, with site the energies spread according to Gaussian distributions. The influence of temperature, applied external fields, and the width of the Gaussian densities of states distribution for both the electron and the hole transporting material are investigated. The results show that the dissociation of geminate charge pairs is assisted by disorder. When the rate for geminate recombination at the interface is very low (<1 ns-1) the simulations predict a high yield for carrier collection, as observed experimentally. Comparison of the simulated and experimentally observed temperature dependence of the collection efficiency indicates that at low temperature dissociation of the geminate charge pairs may be one of the factors limiting the device performance. Furthermore, the simulations show that excess exciton energy liberated in the photoinduced charge transfer process enhances dissociation of the geminate pair and can thereby allow for high yields for carrier collection.
The photophysical properties of a solution processed blend of two semiconducting polymers with electron donating and electron accepting properties, respectively, as used in polymer photovoltaic devices have been investigated. In the binary mixture of poly[2-methoxy-5-(3,7-dimethyloctyloxy)-1,4-phenylenevinylene] (MDMO-PPV) and poly[oxa-1,4-phenylene-(1-cyano-1,2-vinylene)-(2-methoxy-5-(3,7-dimethyloctyloxy)-1,4-phenylene)-1,2-(2-cyanovinylene)-1,4-phenylene] (PCNEPV) photoexcitation of either one of the polymers results in formation of a luminescent exciplex at the interface of the two materials. The high energy of this correlated charge-separated state is consistent with the high open-circuit voltage of the corresponding solar cells (1.36 eV). Application of an electric field results in dissociation of the marginally stable exciplex into charge carriers, which provides the basis for the photovoltaic effect of this combination of materials.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.