Dr. Pierre R. Marcoux Profile

Dr. Pierre R. Marcoux

at CEA-LETI

SPIE Involvement:

Author

Area of Expertise:

in-vitro diagnostics , infectious diseases , antibiotic susceptibility testing , phage therapy , pathogen identification , bloodstream infections

Websites:

Company Website

Publications (14)

Proceedings Article | 20 June 2024 Presentation

Trapping of biological objects on SOI optical photonic crystal micro-resonators

Khouloud Arfaoui, Nicolas Villa, Enrico Tartari, Simon Glicenstein, Emmanuel Picard, Grégory Resch, Emmanuel Hadji, Pierre Marcoux, Romuald Houdré, Valérie Stambouli, Marc Zelsmann

Proceedings Volume PC13008, PC1300809 (2024) https://doi.org/10.1117/12.3022382

KEYWORDS: Photonic crystals, Near field optics, Biomedical optics, Microresonators, Crystal optics, Resonators, Electric fields, Viruses, Silicon, Resistance

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Proceedings Article | 13 March 2024 Presentation

Antibiotic susceptibility testing by infrared multispectral imaging : identification of optimal wavelengths

Stéphan Pissot, Mathieu Dupoy, Pierre Marcoux

Proceedings Volume PC12846, PC128460E (2024) https://doi.org/10.1117/12.3001548

KEYWORDS: Multispectral imaging, Infrared radiation, Infrared imaging, FT-IR spectroscopy, Spectroscopy, Bacteria, Resistance, Mode conditioning cables, Proteins, Light absorption

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Proceedings Article | 5 October 2023 Presentation

On-chip optical nanotweezers for bacteria and bacteriophages viruses trapping and susceptibility testing

Romuald Houdré, Nicolas Villa, Enrico Tartari, Simon Glicenstein, Emmanuel Picard, Pierre Marcoux, Marc Zelsmann, Grégory Resch, Emmanuel Hadji

Proceedings Volume PC12649, PC1264908 (2023) https://doi.org/10.1117/12.2676639

KEYWORDS: Bacteria, Near field optics, Viruses, Photonic crystals, Silicon photonics, Optical tweezers, Optical resonators, Silicon, Resistance, Optical sensing

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Proceedings Article | 5 March 2021 Presentation + Paper

Optical bacteriophage susceptibility testing by SPR (surface plasmon resonance)

Larry O'Connell, Yoann Roupioz, Pierre Marcoux

Proceedings Volume 11661, 116610O (2021) https://doi.org/10.1117/12.2578753

KEYWORDS: Surface plasmons, Optical testing, Prisms, Viruses, Transducers, Optical fibers, Multiplexing, Molecules, Microfluidics

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Proceedings Article | 5 March 2021 Presentation

Multispectral lensless imaging in the mid-infrared for label-free identification of Staphylococcus species

Joel Le Galudec, Mathieu Dupoy, Pierre Marcoux

Proceedings Volume 11655, 116551E (2021) https://doi.org/10.1117/12.2578264

KEYWORDS: Multispectral imaging, Mid-IR, Microorganisms, Chemical analysis, Biological research, Visualization, Statistical analysis, Solid state physics, Quantum cascade lasers

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Proceedings Article | 1 April 2020 Presentation + Paper

Mid-infrared multispectral lensless imaging for wide-field and label-free microbial identification

Joël Le galudec, Mathieu Dupoy, Véronique Rebuffel, Pierre Marcoux

Proceedings Volume 11359, 113590B (2020) https://doi.org/10.1117/12.2557502

KEYWORDS: Multispectral imaging, Bacteria, Mid-IR, Databases, Infrared imaging, Bolometers, Biological research, Transmittance, Quantum cascade lasers, Light sources

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Microbial identification is a critical process aiming at identifying the species contained in a biological sample, with applications in healthcare, industry or even national security. Traditionally, this process relies either on MALDI-TOF mass spectroscopy, on biochemical tests and on the observation of the morphology of colonies after growth on a Petri dish. Here is presented an innovative method for label-free optical identification of pathogens, based on the multispectral infrared imaging of colonies. This lensless imaging technique enables a high-throughput analysis and wide-field analysis of agar plates. It could yield very high correct identification rates as it relies on an optical fingerprint gathering both spectroscopic and morphologic features. The setup consists of a Quantum Cascade Lasers light source and an imager, a square 2.72 by 2.72 mm uncooled bolometer array. Microorganisms to be analyzed are streaked on a porous growth support compatible with infrared imaging, laid on top of an agar plate for incubation. When imaging is performed, growth support is put in close contact with the imaging sensor and illuminated at different wavelengths. After acquisition, an image descriptor based on spectral and morphological features is extracted for each microbial colony. Supervised classification is finally performed with a Support Vector Machine algorithm and tested with tenfold cross-validation. A first database collecting 1012 multispectral images of colonies belonging to five different species has already been acquired with this system, resulting in a correct identification rate of 92%. For these experiments, multispectral images are acquired at nine different wavelengths, between 5.6 and 8 μm. Considering the optimization possibilities of the image descriptors currently used and the ongoing development of the uncooled bolometers technology, these very first results are promising and could be dramatically improved with further experiments. Thereby, mid-infrared multispectral lensless imaging has the potential to become a fast and precise Petri dish analysis technology.

Proceedings Article | 1 April 2020 Presentation

Phage susceptibility testing with lensless imaging technique (Conference Presentation)

Prisca Perlemoine, Emmanuel Picard, Marc Zelsmann, Alexis Maire, Emmanuel Hadji, Eric Lacot, Pierre Marcoux

Proceedings Volume 11362, 1136209 (2020) https://doi.org/10.1117/12.2554168

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Proceedings Article | 10 March 2020 Presentation

Phage susceptibility testing with lensless imaging technique (Conference Presentation)

Prisca Perlemoine, Emmanuel Picard, Emmanuel Hadji, Marc Zelsmann, Alexis Maire, Eric Lacot, Pierre Marcoux

Proceedings Volume 11223, 112230D (2020) https://doi.org/10.1117/12.2543785

KEYWORDS: Bacteria, Optical testing, Absorbance, Microfluidics, Sensors, Resistance, Microfluidic imaging, Optical sensors, Cameras, Optical components

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Proceedings Article | 22 July 2019 Paper

Results on identification of bacteria aging in complex environmental samples using Raman spectroscopy

V. Rebuffel, J.-C. Baritaux, E. Bergmann, P. Marcoux, I. Espagnon, S. Morales

Proceedings Volume 11075, 110750J (2019) https://doi.org/10.1117/12.2527141

KEYWORDS: Bacteria, Databases, Raman spectroscopy, Pathogens, Microorganisms, Classification systems, Imaging systems, Imaging spectroscopy, Environmental sensing, Confocal microscopy

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Proceedings Article | 17 September 2018 Presentation

Optical trapping and Gram type differentiation of living bacteria with 2D photonic crystal cavities (Conference Presentation)

Rita Therisod, Manon Tardif, Emmanuel Picard, Pierre Marcoux, Victor Gaude, Jean-Baptiste Jager, Emmanuel Hadji, David Peyrade, Romuald Houdré

Proceedings Volume 10723, 107231Z (2018) https://doi.org/10.1117/12.2319666

KEYWORDS: Bacteria, Photonic crystals, Optical tweezers, Optical resonators, Biological research, Pathogens, Viruses, Microfluidics, Laser damage threshold, Optofluidics

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Proceedings Article | 17 September 2018 Presentation

Bacterial stress monitoring with an optical 1D microcavity (Conference Presentation)

Manon Tardif, Rita Therisod, Emmanuel Picard, Pierre R. Marcoux, Victor Gaude, Jean-Baptiste Jager, Romuald Houdré, Emmanuel Hadji, David Peyrade

Proceedings Volume 10723, 107231G (2018) https://doi.org/10.1117/12.2321038

KEYWORDS: Near field optics, Optical microcavities, Optical tweezers, Resistance, Biological research, Diagnostics, Microbiology, Pathogens, Integrated photonics, Nondestructive evaluation

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Proceedings Article | 8 February 2018 Paper

Elastic light scattering for clinical pathogens identification: application to early screening of Staphylococcus aureus on specific medium

E. Schultz, V. Genuer, P. Marcoux, O. Gal, C. Belafdil, D. Decq, Max Maurin, S. Morales

Proceedings Volume 10479, 1047909 (2018) https://doi.org/10.1117/12.2287698

KEYWORDS: Databases, Light scattering, Scattering, Image classification, Pathogens, Laser scattering

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Proceedings Article | 7 March 2016 Presentation + Paper

Optical elastic scattering for early label-free identification of clinical pathogens

Valentin Genuer, Olivier Gal, Jérémy Méteau, Pierre Marcoux, Emmanuelle Schultz, Éric Lacot, Max Maurin, Jean-Marc Dinten

Proceedings Volume 9698, 96980A (2016) https://doi.org/10.1117/12.2211021

KEYWORDS: Scattering, Yeast, Databases, Diagnostics, Pathogens, Bacteria, Near field diffraction, Laser scattering, Optical testing, Zernike polynomials, Light scattering, Opacity, Lenses, Beam shaping

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Proceedings Article | 4 March 2014 Paper

Differentiating the growth phases of single bacteria using Raman spectroscopy

S. A. Strola, P. R. Marcoux, E. Schultz, R. Perenon, A.-C. Simon, I. Espagnon, C. P. Allier, J-M. Dinten

Proceedings Volume 8939, 893905 (2014) https://doi.org/10.1117/12.2041446

KEYWORDS: Raman spectroscopy, Bacteria, Spectroscopy, Proteins, Quartz, Mode conditioning cables, Absorbance, Imaging systems, Chemical analysis, Nondestructive evaluation

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Showing 5 of 14 publications

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