Laser micromachining of biofactory-on-a-chip devices

Julian P.H. Burt; Andrew D. Goater; Christopher J. Hayden; John A. Tame

doi:10.1117/12.470637

18 June 2002 Laser micromachining of biofactory-on-a-chip devices

Julian P.H. Burt, Andrew D. Goater, Christopher J. Hayden, John A. Tame

Proceedings Volume 4637, Photon Processing in Microelectronics and Photonics; (2002) https://doi.org/10.1117/12.470637
Event: High-Power Lasers and Applications, 2002, San Jose, California, United States

Abstract

Excimer laser micromachining provides a flexible means for the manufacture and rapid prototyping of miniaturized systems such as Biofactory-on-a-Chip devices. Biofactories are miniaturized diagnostic devices capable of characterizing, manipulating, separating and sorting suspension of particles such as biological cells. Such systems operate by exploiting the electrical properties of microparticles and controlling particle movement in AC non- uniform stationary and moving electric fields. Applications of Biofactory devices are diverse and include, among others, the healthcare, pharmaceutical, chemical processing, environmental monitoring and food diagnostic markets. To achieve such characterization and separation, Biofactory devices employ laboratory-on-a-chip type components such as complex multilayer microelectrode arrays, microfluidic channels, manifold systems and on-chip detection systems. Here we discuss the manufacturing requirements of Biofactory devices and describe the use of different excimer laser micromachined methods both in stand-alone processes and also in conjunction with conventional fabrication processes such as photolithography and thermal molding. Particular attention is given to the production of large area multilayer microelectrode arrays and the manufacture of complex cross-section microfluidic channel systems for use in simple distribution and device interfacing.

Citation Download Citation

Julian P.H. Burt, Andrew D. Goater, Christopher J. Hayden, and John A. Tame "Laser micromachining of biofactory-on-a-chip devices", Proc. SPIE 4637, Photon Processing in Microelectronics and Photonics, (18 June 2002); https://doi.org/10.1117/12.470637

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