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26 February 2024 Nonlinear optical response of upconverting nanoparticles and its versatile applications with inherent three-dimensional capabilities: from microscopy to therapy
Jeongmo Kim, Seunghun Lee, Chaiheon Lee, Yundon Jeong, Kyunghwan Kim, Kibum Nam, Hyungwon Jin, Yuha Choi, Hyun-Jin Kim, Heungjin Ryu, Jae-Ick Kim, Jongnam Park, Tae-Hyuk Kwon, Jinmyoung Joo, Jung-Hoon Park
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Proceedings Volume 13076, SPIE Advanced Biophotonics Conference (SPIE ABC 2023); 1307602 (2024) https://doi.org/10.1117/12.3015686
Event: SPIE Advanced Biophotonics Conference (SPIE ABC 2023), 2023, Jeju, Korea, Republic of
Abstract
Upconverting nanoparticles (UCNPs) exhibit a unique nonlinear optical response, where the emission intensity in the UV/blue range increases non-linearly with the excitation intensity of a continuous-wave (CW) laser in the NIR range. This property can provide inherent three-dimensional (3D) capabilities for various applications. As a demonstration, we illustrate that 3D fluorescence imaging is achievable without the need for a pinhole or ultrafast pulsed lasers, allowing us to image mouse cerebrovascular networks up to the depth of around 700 μm through opaque brain tissues. Additionally, we demonstrate that co-dispersing UCNPs with photosensitizers enables depth-targeted photodynamic therapy with reduced damage to superficial cells. The nonlinear optical properties of UCNPs hold promise for providing 3D capabilities across a wide range of applications.
© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Jeongmo Kim, Seunghun Lee, Chaiheon Lee, Yundon Jeong, Kyunghwan Kim, Kibum Nam, Hyungwon Jin, Yuha Choi, Hyun-Jin Kim, Heungjin Ryu, Jae-Ick Kim, Jongnam Park, Tae-Hyuk Kwon, Jinmyoung Joo, and Jung-Hoon Park "Nonlinear optical response of upconverting nanoparticles and its versatile applications with inherent three-dimensional capabilities: from microscopy to therapy", Proc. SPIE 13076, SPIE Advanced Biophotonics Conference (SPIE ABC 2023), 1307602 (26 February 2024); https://doi.org/10.1117/12.3015686
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KEYWORDS
Nanoparticles
Photodynamic therapy
Near infrared
Fluorescence
Microscopy
Fluorescence microscopy
Nonlinear optics
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