A new integrated SPAD detector is presented. The detector features increased collection efficiencies due to the use of an immersion lens system. Attainable collection improvement factors and application examples are presented.
Quantum technology promises improvements in imaging, computing, and communication, for example using the resource of entanglement between photons with spatial correlations. Detecting spatial correlations, or coincidences, between entangled photons scalably, efficiently, and affordably is therefore an essential capability. However, this task is non-trivial for existing camera technologies, which require low illumination intensities or low detection duty cycles to count coincidences at high signal-to-noise ratios, resulting in long acquisition time, or use expensive custom electronic components. Here, we present an entanglement imaging system based around a novel Single-Photon Avalanche Diode (SPAD) array camera, optimized for sparse illumination with correlated photon pairs. The system is capable of maintaining a duty cycle close to 100%, while simultaneously detecting spatially resolved coincidences with high SNR, enabling the acquisition of real-time entanglement videos at a ~Hz frame rate. We use our system to demonstrate real-time monitoring of entanglement interference visibility, optical system point spread function, as well as real-time widefield entanglement-enhanced phase imaging. Our results show that SPAD array cameras represent a natural choice for scalable entanglement detection and imaging applications.
We present initial evidence of the SOLUS potential for the multimodal non-invasive diagnosis of breast cancer by describing the correlation between optical and standard radiological data and analyzing a case study.
A machine learning classification algorithm is applied to the SOLUS database to discriminate benign and malignant breast lesions, based on absorption and composition properties retrieved through diffuse optical tomography. The Mann-Whitney test indicates oxy-hemoglobin (p-value = 0.0007) and lipids (0.0387) as the most significant constituents for lesion classification, but work is in progress for further analysis. Together with sensitivity (91%), specificity (75%) and the Area Under the ROC Curve (0.83), special metrics for imbalanced datasets (27% of malignant lesions) are applied to the machine learning outcome: balanced accuracy (83%) and Matthews Correlation Coefficient (0.65). The initial results underline the promising informative content of optical data.
InGaAs/InP Single-Photon Avalanche Diodes (SPADs) can achieve high photon detection efficiency (PDE) with a thick absorber, but at the expense of higher dark count rate (DCR). PDE and DCR also depend on the electric field inside the structure, which can be tailored in the design phase and influences the overall performance. We present the design and the experimental characterization of two different 10 μm-diameter InGaAs/InP SPADs. The first one is intended for applications where low noise is the key requirement: at 225 K and 5 V excess bias, it features 1 kcps DCR, 25% PDE at 1550 nm and a timing jitter of 100 ps (FWHM). The second device is an InGaAs/InP SPAD optimized for PDE-enhanced applications, having a PDE up to 50% at 1550 nm, with a DCR of 20 kcps and a timing jitter of 70 ps (FWHM) at 225 K. Alternatively, it features a PDE of 37% at 1550 nm, with a DCR of just 3 kcps and a timing jitter of 100 ps (FWHM). When combined with a custom integrated circuit we developed, both devices show an afterpulsing probability as low as few percent with a gating frequency of 1 MHz and hold-off time of few microseconds at 225 K, allowing to achieve a photon count rate towards 1 Mcps.
New time-correlated single photon counting (TCSPC) applications, like non-line-of-sight imaging, require a new generation of single photon avalanche diodes (SPAD) characterized by an instrument response function (IRF) having not only a narrow peak (< 100 ps FWHM) but also a very fast tail (~75 ps decay time). With such devices it is thus possible to detect two optical pulses as close as 200 ps in time, even if the second one is 2 orders of magnitude weaker than the first one. Such secondary peaks in the TCSPC histogram, can also be caused by reflections from internal optical surfaces of the optoelectronic assembly in which SPADs are mounted and thus are consequently undesirable. Options to mitigate these reflections or reduce the time of flight inside the assembly while not compromising photon detection efficiencies over a wide wavelength range are discussed.
A multimodal instrument for breast imaging was developed, combining ultrasound (morphology), shear wave elastography (stiffness), and time domain multiwavelength diffuse optical tomography (blood, water, lipid, collagen) to improve the non-invasive diagnosis of breast cancer.
To improve non-invasively the specificity in the diagnosis of breast cancer after a positive screening mammography or doubt/suspicious ultrasound examination, the SOLUS project developed a multimodal imaging system that combines: Bmode ultrasound (US) scans (to assess morphology), Color Doppler (to visualize vascularization), shear-wave elastography (to measure stiffness), and time domain multi-wavelength diffuse optical tomography (to estimate tissue composition in terms of oxy- and deoxy-hemoglobin, lipid, water, and collagen concentrations). The multimodal probe arranges 8 innovative photonic modules (optodes) around the US transducer, providing capability for optical tomographic reconstruction. For more accurate estimate of lesion composition, US-assessed morphological priors can be used to guide the optical reconstructions. Each optode comprises: i) 8 picosecond pulsed laser diodes with different wavelengths, covering a wide spectral range (635-1064 nm) for good probing of the different tissue constituents; ii) a large-area (variable, up to 8.6 mm2 ) fast-gated digital Silicon Photomultiplier; iii) the acquisition electronics to record the distribution of time-of-flight of the re-emitted photons. The optode is the basic element of the optical part of the system, but is also a stand-alone, ultra-compact (about 4 cm3 ) device for time domain multi-wavelength diffuse optics, with potential application in various fields.
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