Dr. Alexander P. Shkurinov Profile

Dr. Alexander P. Shkurinov

at MV Lomonosov Moscow State Univ

SPIE Involvement:

Conference Program Committee | Author

Publications (26)

Proceedings Article | 26 November 2023 Poster + Paper

Characterization of the new semiorganic nonlinear crystal of guanylurea hydrogen phosphite in the terahertz range

Nazar Nikolaev, Anton Sinko, Sofya Bychkova, Valery Antsygin, Lev Maximov, Fedor Minakov, Alexander Shkurinov

Proceedings Volume 12776, 1277615 (2023) https://doi.org/10.1117/12.2687665

KEYWORDS: Crystals, Terahertz radiation, Nonlinear crystals, Terahertz spectroscopy, Spectroscopy, Dispersion, Refractive index

Read Abstract +

SPIE Journal Paper | 12 February 2021 Open Access

Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets

Anastasia Lykina, Maxim Nazarov, Maria Konnikova, Ilia Mustafin, Vladimir Vaks, Vladimir Anfertev, Elena Domracheva, Mariya Chernyaeva, Yury Kistenev, Denis Vrazhnov, Vladimir Prischepa, Yulia Kononova, Dmitry Korolev, Olga Cherkasova, Alexander Shkurinov, Alina Y. Babenko, Olga Smolyanskaya

JBO, Vol. 26, Issue 04, 043006, (February 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.4.043006

KEYWORDS: Terahertz radiation, Blood, Plasma, Absorption, Refractive index, Glucose, Proteins, Terahertz spectroscopy, Spectrometers, Water

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 10 October 2020 Presentation

High-repetition-rate cryogenic liquid target for terahertz wave generation

Yiwen E., Yuqi Cao, Fang Ling, Alexander Shkurinov, Yiming Zhu, X.-C. Zhang

Proceedings Volume 11559, 1155905 (2020) https://doi.org/10.1117/12.2575336

KEYWORDS: Terahertz radiation, Liquids, Cryogenics, Nitrogen, Laser applications, Laser development, Laser induced damage, Plasma, Metals, Electro optics

Read Abstract +

Proceedings Article | 8 April 2020 Presentation

THz properties of rat skin and extracts at exposure to hyperosmotic solutions (Conference Presentation)

Ekaterina Lazareva, Maxim Nazarov, Alla Bucharskaya, Valery Tuchin, Alexander Shkurinov

Proceedings Volume 11363, 1136328 (2020) https://doi.org/10.1117/12.2560376

KEYWORDS: Tissue optics, Skin, Terahertz radiation, Optical clearing, Tumors, Scattering, Absorption, Imaging spectroscopy, Glucose, Water

Read Abstract +

Application of many optical methods, such as photoacoustics, optical coherent tomography, and terahertz spectroscopy, for tissue imaging and disease diagnostics is limited due to small probing depth caused by strong scattering and absorption in tissues [1, 2]. It is possible to increase the efficiency of optical techniques by using tissue optical clearing (TOC), which allows one to control tissue optical properties by exposing tissue to biocompatible liquids - optical clearing agents (OCAs). When exposed to an OCA with hyperosmotic properties, such as glycerol or highly concentrated glucose solution, it is possible to achieve a considerable decrease of tissue scattering within the entire spectral range and absorption on the water bands due to refractive index matching phenomenon and dehydration of the tissue, and therefore to get a significant increase of the optical and THz wave transmittance [1-3]. In vitro studies were performed on laboratory rats of the Vistar strain (sexually mature females weighing 300–400 g were used). The animals were inoculated with the tumor cells by subcutaneous injection into the area of the scapulae. Studies were conducted in 28 days after injection. The weight and thickness of the samples were measured before and after optical clearing by using a micrometer with an accuracy of ±0.001 mm and an analytical balance (Scientech, SA210, USA) with an accuracy of ±1 mg. The samples of the area 1.5*1.5 cm2 were placed in a closed sealed container, to which was added 2 ml of OCA. 70% glycerol solution, 40% glucose solution and 50% fructose in a 30% alcohol solution were used with the addition of saline as an OCA. The transmission spectrum of glycerol in the frequency range of 0.05–1.0 THz was measured by using the terahertz (THz) time-domain spectrometer. Measurements of the refractive index of OCA were carried out before the start of the experiment and every 5 minutes after placing the skin sample in the solution with OCA for 15 minutes, then every 10 minutes for another 45 minutes. It was found that the effectiveness of optical clearing of the skin over the tumor is higher compared to healthy skin. A good correlation was shown between the kinetics of the sample mass and THz absorption and refraction. An assessment of skin dehydration also showed that the concentration of water extracted from the skin above the tumor is greater compared to healthy. It is especially important that enhancing the image contrast due to dehydration and TOC in the pathology area is extremely significant in diagnosing precancerous conditions and treating early stages of tumor, due to the possibility of selective increase of the scattering contrast of cell nuclei relative to surrounding cytoplasm and interstitial fluid and thus following their size and internal rearrangements [5].

Proceedings Article | 8 April 2020 Presentation

Study tissue microhemodynamics in area of tumor at optical clearing by speckle-contrast imaging (Conference Presentation)

Polina Dyachenko Timoshina, Alla Bucharskaya, Valery Tuchin, Aleksandr Shkurinov

Proceedings Volume 11363, 113631Q (2020) https://doi.org/10.1117/12.2554992

Read Abstract +

The results of an experimental study of changes in the microcirculation of subcutaneous blood flow in a malignant tumor using laser speckle contrast imaging (LSCI) using an optical clearing agent of 70% glycerol solution are presented. In this study, for hemodynamic monitoring we used the speckle contrast method, which is one of the laser speckle imaging methods. This method is based on calculation of contrast of time-averaged dynamic speckles in dependence on the exposure time at the registration of the speckle-modulated images. Analysis of change of hemodynamic was carried out depending on the stage of development of pathologyIn research, we used 15 white laboratory rats Wistar weighing 300-500 g. A tumor was inoculated in laboratory rats by subcutaneous injection of 0.5 ml of a 25% tumor suspension into the area of the shoulder blades in a Hanks solution strain of PC1 alveolar liver cancer. Laboratory animals were divided into three groups, the first included healthy animals, the second - animals with an inoculated tumor 14 days after injection and the third - animals with an inoculated tumor 28 days after injection. It was found that the blood flow rate in pathological group No. 2 was reduced by 25% relative to control measurements of group No. 1, in pathological group No. 3 increased by 20% relative to control measurements. Also, the results showed that the use of a 70% glycerol solution reduced the blood flow velocity in the control group by about 2 times. Moreover, in pathological groups, the effect of the solution on the blood flow is more pronounced, in the group, the measurements on which were carried out 14 days after the inoculation of the tumor, the blood flow rate decreased by 2.8 times, after 28 days - by 4 times. The results obtained in the study of disorders of the microcirculation of the subcutaneous blood flow under the conditions of the development of a malignant tumor show that the development of diseases in animals causes changes in the microcirculatory system, and the use of optical clearing agents demonstrates changes in vascular permeability under conditions of the development of pathologies.

SPIE Journal Paper | 8 February 2020

Potential clinical applications of terahertz reflectometry for the assessment of the tear film stability

Ilya Ozheredov, Tatyana Safonova, Ekaterina Sikach, Mikhail Mischenko, Mikhail Prokopchuk, Andrew Larichev, Yulia Listopadskaya, Alexander Shkurinov

OE, Vol. 59, Issue 06, 061622, (February 2020) https://doi.org/10.1117/12.10.1117/1.OE.59.6.061622

KEYWORDS: Terahertz radiation, Reflectometry, Eye, Cornea, Signal detection, Receivers, In vivo imaging, Diagnostics, Optical engineering, Reflectivity

Read Abstract +

Proceedings Article | 21 April 2016 Paper

Investigation of bovine serum albumin glycation by THz spectroscopy

Olga Cherkasova, Maxim Nazarov, Alexander Shkurinov

Proceedings Volume 9917, 991706 (2016) https://doi.org/10.1117/12.2229741

KEYWORDS: Terahertz radiation, Spectroscopy, Glucose, Proteins, Absorption, Molecules, Water, Refraction, Dielectrics, Dielectric relaxation

Read Abstract +

Proceedings Article | 21 October 2015 Paper

Spatio-spectral characteristics of THz radiation from two-color femtosecond filament

Vera Andreeva, Nikolay Panov, Mikhail Esaulkov, Olga Kosareva, Petr Solyankin, Daniil Shipilo, Alexander Borodin, Vladimir Makarov, Alexander Shkurinov

Proceedings Volume 9651, 96510K (2015) https://doi.org/10.1117/12.2196801

KEYWORDS: Terahertz radiation, Plasma, Femtosecond phenomena, Pulsed laser operation, Nonlinear response, Polarization, Transient nonlinear optics, Numerical simulations, Ionization, Neon

Read Abstract +

Proceedings Article | 30 January 2014 Paper

In-vitro terahertz spectroscopy of rat skin under the action of dehydrating agents

Aleksandr Kolesnikov, Ekaterina Kolesnikova, Daria Tuchina, Artem Terentyuk, Maxim Nazarov, Alexander Skaptsov, Alexander Shkurinov, Valery Tuchin

Proceedings Volume 9031, 90310D (2014) https://doi.org/10.1117/12.2052226

KEYWORDS: Tissues, Tumors, Skin, Terahertz radiation, Transmittance, Data modeling, Spectroscopy, Glucose, Terahertz spectroscopy, Infrared spectroscopy

Read Abstract +

Proceedings Article | 29 February 2012 Paper

Studying of dielectric properties of polymers in the terahertz frequency range

E. Fedulova, M. Nazarov, A. Angeluts, M. Kitai, V. Sokolov, A. Shkurinov

Proceedings Volume 8337, 83370I (2012) https://doi.org/10.1117/12.923855

KEYWORDS: Polymethylmethacrylate, Polymerization, Spectroscopy, Refractive index, Crystals, Refraction, Dielectrics, Absorption, Terahertz radiation, Polymers

Read Abstract +

Proceedings Article | 12 January 2011 Paper

Electronic properties and influence of doping on GaSe crystal nonlinear optical parameters for the applications in terahertz range

M. Nazarov, A. Kosobutsky, S. Yu. Sarkisov, V. Brudnyi, O. Tolbanov, A. Shkurinov

Proceedings Volume 7993, 799326 (2011) https://doi.org/10.1117/12.881836

KEYWORDS: Crystals, Gases, Nonlinear crystals, Terahertz radiation, Absorption, Doping, Semiconductors, Millimeter wave sensors, Solids, Laser crystals

Read Abstract +

Proceedings Article | 9 June 2008 Paper

Tooth study by terahertz time-domain spectroscopy

M. Nazarov, A. Shkurinov, V. Tuchin

Proceedings Volume 6791, 679109 (2008) https://doi.org/10.1117/12.803968

KEYWORDS: Terahertz radiation, Teeth, Absorption, Refractive index, Tissues, Refraction, Spectroscopy, Terahertz spectroscopy, Water, Beam splitters

Read Abstract +

Proceedings Article | 26 April 2007 Paper

Modification of terahertz pulsed spectrometer to study biological samples

M. Nazarov, A. Shkurinov, V. Tuchin, O. Zhernovaya

Proceedings Volume 6535, 65351J (2007) https://doi.org/10.1117/12.740994

KEYWORDS: Terahertz radiation, Absorption, Spectroscopy, Refraction, Crystals, Water, Nonlinear crystals, Glucose, Laser crystals, Pulsed laser operation

Read Abstract +

Proceedings Article | 6 December 2006 Paper

Features of femtosecond laser pulses interaction with nematic liquid crystals

V. Enikeeva, V. Makarov, I. Ozheredov, A. Shkurinov

Proceedings Volume 6023, 602303 (2006) https://doi.org/10.1117/12.648165

KEYWORDS: Femtosecond phenomena, Absorption, Liquid crystals, Continuous wave operation, Luminescence, Charge-coupled devices, Adsorption, Nonlinear optics, Liquids

Read Abstract +

Proceedings Article | 19 April 2006 Paper

Terahertz pulse plasmon interaction with metal grating

V. Makarov, L. Mukina, M. Nazarov, A. Shkurinov

Proceedings Volume 6194, 61940M (2006) https://doi.org/10.1117/12.662064

KEYWORDS: Plasmons, Terahertz radiation, Metals, Surface plasmons, Picosecond phenomena, Crystals, Reflection, Aluminum, Radio propagation, Specular reflections

Read Abstract +

Proceedings Article | 19 April 2006 Paper

Terahertz time-domain spectroscopy and spectrochronography of amino acids and polypeptides

N. Brandt, A. Yu. Chikishev, M. Nazarov, O. Okhotnikov, O. Parashchuk, S. Shkelnyuk, D. Sapozhnikov, I. Smirnova, A. Shkurinov

Proceedings Volume 6194, 619408 (2006) https://doi.org/10.1117/12.662491

KEYWORDS: Raman spectroscopy, Terahertz radiation, Bridges, Molecules, Proteins, Spectroscopy, Terahertz spectroscopy, Absorption, Fourier transforms, Electrons

Read Abstract +

Proceedings Article | 12 September 2003 Paper

Time history of laser pulse polarization transformation as a tool of the isotropic-nematic phase transition in liquid crystals

Vladimir Makarov, Tamara Il'inova, Tatiana Marchenko, Aleksandr Shkurinov, Alexander Zolot'ko

Proceedings Volume 4972, (2003) https://doi.org/10.1117/12.479004

KEYWORDS: Liquid crystals, Nonlinear optics, Polarization, Pulsed laser operation, Elliptical polarization, Absorption, Transform theory, Wave propagation, Gaussian pulse, Solids

Read Abstract +

Proceedings Article | 11 June 2003 Paper

Time-resolved nonlinear surface plasmon optics

Yurii Lozovik, S. Merkulova, M. Nazarov, Aleksandr Shkurinov, P. Masselin

Proceedings Volume 5023, (2003) https://doi.org/10.1117/12.511845

KEYWORDS: Femtosecond phenomena, Nonlinear optics, Surface plasmons, Plasmons, Metals, Spectroscopy, Nanostructures, Second-harmonic generation, Nonlinear dynamics, Phase matching

Read Abstract +

Proceedings Article | 24 July 2002 Paper

Light-induced director reorientation in nematic liquid crystal under femtosecond pulses

A. Goncharov, V. Kitaeva, Ilya Ozheredov, Aleksandr Shkurinov, Alexander Zolot'ko

Proceedings Volume 4751, (2002) https://doi.org/10.1117/12.475924

KEYWORDS: Femtosecond phenomena, Liquid crystals, Radiation effects, Phase shifts, Picosecond phenomena, Physics, Information operations, Pulsed laser operation, Refractive index

Read Abstract +

Proceedings Article | 9 May 2001 Paper

Two-surface plasmon interaction to femtosecond surface spectroscopy

Yurii Lozovik, M. Nazarov, Aleksandr Shkurinov

Proceedings Volume 4243, (2001) https://doi.org/10.1117/12.426680

KEYWORDS: Femtosecond phenomena, Spectroscopy, Plasmons, Second-harmonic generation, Nonlinear optics, Signal detection, Mirrors, Gold, Surface plasmons, Phase matching

Read Abstract +

Proceedings Article | 5 February 1999 Paper

Time- and space-correlated single-photon counting system for fluorescence microspectroscopy of biological specimens

Mikhail Ainbund, Sergei Arzhantsev, Andrey Chikishev, Klaus Kemnitz, Nikolai Koroteev, Aleksandr Shkurinov, Bulat Toleutaev, Evgenii Turbin

Proceedings Volume 3732, (1999) https://doi.org/10.1117/12.340014

KEYWORDS: Luminescence, Raman spectroscopy, Imaging spectroscopy, Molecules, Photons, Photomultipliers, Sensors, Microchannel plates, Spatial resolution, Nd:YAG lasers

Read Abstract +

Proceedings Article | 28 January 1999 Paper

Optical diffraction and second harmonic generation with femtosecond laser pulses in chiral Sm-C* liquid crystals

Vladimir Bushuev, Boris Mantsyzov, Ilya Ozheredov, Aleksandr Shkurinov, Nikolai Koroteev

Proceedings Volume 3733, (1999) https://doi.org/10.1117/12.340046

KEYWORDS: Diffraction, Liquid crystals, Polarization, Geometrical optics, Crystals, Liquids, Crystal optics, Data modeling, Femtosecond phenomena, Harmonic generation

Read Abstract +

Proceedings Article | 1 April 1998 Paper

Systems of digital optical memory based on two-photon amplitude data writing in three-dimensional photosensitive media with the using femtosecond laser pulses: comparison of phase and amplitude appr

Andrey Chikishev, Nikolai Koroteev, Sergei Krikunov, S. Magnitskii, Aleksandr Shkurinov, Alexei Zheltikov

Proceedings Volume 3402, (1998) https://doi.org/10.1117/12.304931

KEYWORDS: Optical storage, Femtosecond phenomena, Digital holography, Holography, Photochromic materials, Data storage, Luminescence, 3D optical data storage, Absorption, Binary data

Read Abstract +

Proceedings Article | 1 January 1998 Paper

Femtosecond microspectrophotometer for measurement of efficient yield of two-photon photoreactions

A. Angeluts, Nikolai Koroteev, S. Magnitskii, Ilya Ozheredov, Aleksandr Shkurinov

Proceedings Volume 3347, (1998) https://doi.org/10.1117/12.301416

KEYWORDS: Absorption, Femtosecond phenomena, Absorbance, Molecules, Signal detection, Photochromic materials, Argon ion lasers, Data modeling, Optical amplifiers, Sapphire lasers

Read Abstract +

Proceedings Article | 17 June 1993 Paper

Luciferase intramolecular dynamics studied by time-resolved fluorescence spectroscopy

Lubov Brovko, Andrey Chikishev, Olga Gandelman, Aleksandr Shkurinov

Proceedings Volume 1921, (1993) https://doi.org/10.1117/12.146114

KEYWORDS: Molecules, Fluorescence anisotropy, Anisotropy, Proteins, Fluorescence spectroscopy, Spectroscopy, Laser spectroscopy, Polarizers, Time resolved spectroscopy, Luminescence

Read Abstract +

Proceedings Article | 17 June 1993 Paper

Nonlinear spectroscopy of chiral molecules: new spectroscopic techniques for studying left-right mirror asymmetry of biological molecules

A. Dubrovskii, Nikolai Koroteev, Aleksandr Shkurinov

Proceedings Volume 1922, (1993) https://doi.org/10.1117/12.146177

KEYWORDS: Molecular spectroscopy, Second-harmonic generation, Polarization, Molecules, Spectroscopy, Nonlinear optics, Liquids, Mirrors, Molecular biology, Harmonic generation

Read Abstract +