Ms. Bushra Shakoor Profile

Bushra Shakoor

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Proceedings Article | 1 July 2021 Paper

Synthesis spectroscopic investigation and pharmacological evaluation of metal complex containing O, S donor ligand

Bushra Shakoor, Faiza Asghar

Proceedings Volume 11877, 1187709 (2021) https://doi.org/10.1117/12.2600495

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Thiourea, an O and S containing compound, is an important reagent in organic synthesis, used as a source of sulphides, acts as a reactant in synthesis of many heterocyclic compounds. The presence of O and S donor atoms offers a multitude of bonding possibilities, enables them to act as versatile ligands and form stable complexes. The purpose of this research work was to synthesize the transition metal complex of acyl derivative possessing oxygen and sulfur donor atoms that can act as efficient antibacterial and antifungal agents. An O, S donor ligand was prepared by the reaction between isothiocyanate and substituted amine. Metal complex of this bidentate ligand was synthesized by the reaction between metal salt and ligand. Zinc based thiourea such as: 3-(4-bromobenzoyl)-1-ethyl-1-(4-fluorophenyl) thiourea display a broad spectrum of biological applications. Acyl derivative and its complex was structurally analyzed by Fourier transform infrared spectroscopy and elemental analysis. Biological activity was checked by preparing different culture media.

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