The abovementioned authors are named on behalf of their respective groups.
The recent rediscovery of the “Flash Effect” revived the interest in high and ultra-high dose-rate radiation effects throughout the radiobiology community, promising protection of normal tissue, while simultaneously not altering tumour control. Systematic preclinical studies at (modified) clinical accelerators resulted in a recipe of necessary beam parameters for the induction of electron Flash effect (doi:10.3389/fonc.2019.01563), whereas for protons the optimal parameter setting is still under investigation. Expanding the clinical parameter range the “Dresden platform for high-dose rate radiobiology” enables electron and proton experiments with dose rates of up to 109 Gy/s and more flexible beam pulse structures. The general applicability of these beams for radiobiological studies was proven with zebrafish embryos a simple but robust normal tissue in vivo model. Overall, the analysis of the induced radiation effects reveal a clear normal tissue protecting Flash effect for ultra-high dose rate electron and proton beams relative to their conventional beam delivery.
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