Ms. Martina Bottoni Profile

Martina Bottoni

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 4 March 2022 Presentation + Paper

Functional brain mapping with dual-slope frequency-domain near-infrared spectroscopy

Giles Blaney, Angelo Sassaroli, Cristianne Fernandez, Martina Bottoni, Sergio Fantini

Proceedings Volume 11946, 1194602 (2022) https://doi.org/10.1117/12.2610664

KEYWORDS: Hemodynamics, Sensors, Near infrared spectroscopy, Absorption, Brain mapping, Calibration, Brain activation, Visual cortex, Scattering

Read Abstract +

Functional Near-InfraRed Spectroscopy (fNIRS) measures cerebral hemodynamics associated with brain activation. Non-invasive optical measurements of cerebral hemodynamics are often confounded by superficial, extra-cerebral hemodynamics and by instrumental and motion artifacts. These confounds are especially prominent in optical intensity data collected at a single source-detector distance. Alternatively, slope methods and frequency-domain measurements of the phase of photon-density waves have been proposed. Here, we first demonstrate the ability of a special slope method (dual-slope) to efficiently suppress instrumental artifacts. Then, a dual-slope imaging array is utilized to generate and compare single-distance and dual-slope intensity and phase data collected on the visual cortex of a human subject during a contrast reversing visual stimulation protocol. The measured hemodynamic traces associated with visual stimulation exhibit a larger amplitude when they are derived from dual-slope versus single-distance data, and from phase versus intensity data. In particular, the functional hemodynamics obtained from dual-slope phase data feature the largest amplitude. These results indicate the greater sensitivity to brain tissue achieved by dual-slope versus single-distance data, and by phase versus intensity data. The conclusion of this work is that dual-slope intensity (in continuous-wave fNIRS) and dual-slope or single-distance phase (in frequency-domain fNIRS) appear to be most effective for functional brain measurements, with the significant practical advantage offered by the minimal sensitivity of dual-slope measurements to a variety of artifacts.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years