Prof. Yu Chen Profile

Prof. Yu Chen

at Fujian Normal Univ

SPIE Involvement:

Conference Program Committee | Author

Publications (75)

Proceedings Article | 20 November 2024 Paper

A visual tracking-based algorithm for real-time probe localization and 3D reconstruction in optical coherence tomography

Rui Ma, Yu Chen, Xian Du

Proceedings Volume 13242, 132420E (2024) https://doi.org/10.1117/12.3037324

KEYWORDS: Optical coherence tomography, Cameras, Detection and tracking algorithms, Visualization, 3D tracking, Reconstruction algorithms, Biomedical optics, Biomedical applications, 3D scanning, Imaging systems

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Proceedings Article | 13 March 2024 Presentation

Evaluation of human kidney for transplantation using polarization-sensitive optical coherence tomography

Feng Yan, Chen Wang, Bornface Mutembei, Zaid Alhajeri, Qinghao Zhang, Ebenezer Raj Selvarai Mercyshalinie, Zhongxin Yu, Yu Chen, Kar-Ming Fung, Qinggong Tang

Proceedings Volume PC12834, PC1283404 (2024) https://doi.org/10.1117/12.3001968

KEYWORDS: Kidney, Transplantation, Optical coherence tomography, Tissues, Perfusion imaging, Natural surfaces, Imaging systems, Two photon excitation microscopy, Optical surfaces, Collagen

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Proceedings Article | 13 March 2024 Presentation

Development of tissue-mimicking phantoms for pulse oximetry

Anant Bhusal, Sandhya Vasudevan, Md Sadique Hasan, Masoud Farahmand, William Vogt, Sandy Weininger, Yu Chen, Joshua Pfefer

Proceedings Volume PC12833, PC128330A (2024) https://doi.org/10.1117/12.3004468

KEYWORDS: Oximetry, Tissues, Polydimethylsiloxane, Standards development, Point-of-care devices, Microfluidics, Silicon, Quality control, Polymers, Oximeters

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Proceedings Article | 13 March 2024 Presentation + Paper

Modeling light-tissue interactions in pulse oximetry: effect of device design and skin pigmentation

Mousa Moradi, Sandhya Vasudevan, Anant Bhusal, Sandy Weininger, Yu Chen, Joshua Pfefer

Proceedings Volume 12833, 1283302 (2024) https://doi.org/10.1117/12.3004189

KEYWORDS: Oximetry, Skin, Monte Carlo methods, Transmittance, Modeling, Oximeters, Photons, Calibration, Scattering, Modulation

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Proceedings Article | 17 March 2023 Presentation

Test method for evaluating the photocytotoxic potential of fluorescence imaging products

Shruti Vig, Brandon Gaitan, Lucas Frankle, Miriam Adwan, Yu Chen, Rosalie Elespuru, Joshua Pfefer, Huang-Chiao Huang

Proceedings Volume PC12359, PC1235908 (2023) https://doi.org/10.1117/12.2652255

KEYWORDS: Luminescence, Safety, Visualization, Tissues, Standards development, Skin, Molecules, In vitro testing

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Proceedings Article | 16 April 2022 Presentation + Paper

Feasibility of robotic-assisted optical coherence tomography with extended scanning area for pre-transplant kidney monitoring

Xihan Ma, Mousa Moradi, Haithem Mustafa, Martin Hunter, Yu Chen, Haichong K. Zhang

Proceedings Volume 11948, 1194803 (2022) https://doi.org/10.1117/12.2612677

KEYWORDS: Optical coherence tomography, Tissues, 3D scanning, Kidney, Cameras, Surgery, Scanners, Robotics, Robotic systems, Natural surfaces

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Proceedings Article | 7 March 2022 Poster + Presentation + Paper

Soft attention-based U-NET for automatic segmentation of OCT kidney images

Mousa Moradi, Xian Du, Yu Chen

Proceedings Volume 11948, 119480N (2022) https://doi.org/10.1117/12.2612281

KEYWORDS: Image segmentation, Kidney, Optical coherence tomography, Data modeling, Medical imaging, Performance modeling, Pancreas, Image processing, Surgery, Imaging systems

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Proceedings Article | 7 March 2022 Presentation

Novel optical imaging methods for photoimmunotherapy monitoring

Qinggong Tang, Feng Yan, Chen Wang, Shulian Wu, Ryuhei Okada, Tadanobu Nagaya, Yuhong Fang, Hui Li, Yu Chen, Hisataka Kobayashi

Proceedings Volume PC11961, PC1196106 (2022) https://doi.org/10.1117/12.2607879

KEYWORDS: Photoimmunotherapy, Optical imaging, Tumors, Blood vessels, Optical coherence tomography, Near infrared, Blood, 3D image processing, Luminescence, 3D acquisition

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Proceedings Article | 7 March 2022 Presentation

Development of an in silico NIRS model to inform the development of performance test methods

Brandon Gaitan, Alice Truong, Mousa Moradi, Yu Chen, Joshua Pfefer

Proceedings Volume PC11951, PC1195107 (2022) https://doi.org/10.1117/12.2609971

KEYWORDS: Near infrared spectroscopy, Performance modeling, Monte Carlo methods, Signal detection, Sensors, Reflectivity, Oximeters, Photons, Diffuse reflectance spectroscopy, Computer simulations

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Proceedings Article | 5 March 2021 Presentation

Mesoscopic imaging of functional connectivity in mouse cortex

Qinggong Tang, Vassiliy Tsytsarev, Feng Yan, Chen Wang, Reha Erzurumlu, Yu Chen

Proceedings Volume 11629, 1162926 (2021) https://doi.org/10.1117/12.2576577

KEYWORDS: Neurons, Spatial resolution, Neuroimaging, Image visualization, Functional imaging, Brain, Voltage sensitive dyes, Visualization, Two photon excitation microscopy, Temporal resolution

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Proceedings Article | 5 March 2021 Presentation

Quantifying the photochemical damage potential of fluorescence contrast agents: singlet oxygen production

Brandon Gaitan, Rosalie Elespuru, Ellen Oskoui, Mariam Adwan, Anqi He, Huang-Chiao Huang, Yu Chen, Joshua Pfefer

Proceedings Volume 11660, 116600A (2021) https://doi.org/10.1117/12.2579521

KEYWORDS: Oxygen, Luminescence, Safety, Molecules, Industrial chemicals, Visualization, Standards development, Optical imaging, Molecular imaging

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SPIE Journal Paper | 2 December 2020 Open Access

In vivo voltage-sensitive dye imaging of mouse cortical activity with mesoscopic optical tomography

Qinggong Tang, Vassiliy Tsytsarev, Feng Yan, Chen Wang, Reha Erzurumlu, Yu Chen

NPh, Vol. 7, Issue 04, 041402, (December 2020) https://doi.org/10.1117/12.10.1117/1.NPh.7.4.041402

KEYWORDS: Neurons, Photostimulation, Luminescence, In vivo imaging, Brain, 3D image processing, Sensors, Neuroimaging, Voltage sensitive dyes, Imaging systems

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SPIE Journal Paper | 26 September 2020 Open Access

Depth-resolved imaging of photosensitizer in the rodent brain using fluorescence laminar optical tomography

Brandon Gaitan, Collin Inglut, Yi Liu, Yu Chen, Huang-Chiao Huang

JBO, Vol. 25, Issue 09, 096007, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.096007

KEYWORDS: Brain, Tissues, Neuroimaging, Luminescence, Signal attenuation, Imaging systems, Optical tomography, Capillaries, 3D image processing, Optical coherence tomography

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Proceedings Article | 20 April 2020 Presentation

Using fluorescence laminar optical tomography to measure the distribution photodynamic drug in the brain to optimize dosage and treatment time (Conference Presentation)

Brandon Gaitan, Collin Inglut, Yu Chen, Huang-Chiao Huang

Proceedings Volume 11219, 112190J (2020) https://doi.org/10.1117/12.2550498

KEYWORDS: Luminescence, Brain, Optical tomography, Optical testing, Plasma display panels, Tissue optics, Tumors, Brain cancer, Blood brain barrier, Oxygen

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Proceedings Article | 10 March 2020 Open Access

Update on AAPM task group 311: guidance for technical performance evaluation for fluorescence guided surgery systems (Conference Presentation)

Brian Pogue, Timothy Zhu, Vasilis Ntziachristos, Brian Wilson, Keith Paulsen, Sylvain Gioux, Robert Nordstrom, Joshua Pfefer, Bruce Tromberg, Heidrun Wabnitz, Arjun Yodh, Yu Chen, Maritoni Litorja

Proceedings Volume 11222, 112220S (2020) https://doi.org/10.1117/12.2546885

KEYWORDS: Luminescence, Surgery, Imaging systems, Image processing, Clinical trials, Image quality, Tissues

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SPIE Journal Paper | 15 April 2019 Open Access

Phantom-based evaluation of near-infrared intracranial hematoma detector performance

Jianting Wang, Jonathan Lin, Yu Chen, Cristin Welle, T. Joshua Pfefer

JBO, Vol. 24, Issue 04, 045001, (April 2019) https://doi.org/10.1117/12.10.1117/1.JBO.24.4.045001

KEYWORDS: Sensors, Near infrared spectroscopy, Tissues, Signal attenuation, Brain, Skull, Sensor performance, Traumatic brain injury, Standards development, Blood

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SPIE Journal Paper | 6 July 2018 Open Access

Depth-resolved mapping of muscular bundles in myocardium pulmonary junction using optical coherence tomography

Zhifang Li, Qinggong Tang, Timm Dickfeld, Yu Chen

JBO, Vol. 23, Issue 07, 076004, (July 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.7.076004

KEYWORDS: Optical coherence tomography, Photovoltaics, Atrial fibrillation, Tissues, Binary data, Image segmentation, Visualization, Veins, Light scattering, Lithium

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Proceedings Article | 14 March 2018 Presentation

Biomimetic 3D-printed neurovascular phantoms for macro-and micro-scale Near-infrared Fluorescence Imaging (Conference Presentation)

Yi Liu, Pejhman Ghassemi, Hannah Horng, Udayakumar Kanniyappan, Yu Chen, T. Joshua Pfefer

Proceedings Volume 10486, 1048607 (2018) https://doi.org/10.1117/12.2290438

KEYWORDS: Imaging systems, Biomimetics, Luminescence, 3D printing, Angiography, Printing, 3D image processing, Visualization, Pathology, Retinal scanning

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Proceedings Article | 26 February 2018 Presentation + Paper

Novel fiber optic-based needle redox imager for cancer diagnosis

Udayakumar Kanniyappan, He Xu, Qinggong Tang, Brandon Gaitan, Yi Liu, Lin Li, Yu Chen

Proceedings Volume 10489, 104890J (2018) https://doi.org/10.1117/12.2293133

KEYWORDS: Cancer, Endoscopy, Imaging systems, Breast cancer, Luminescence, Tissues, Fluorescence spectroscopy, Spectroscopy, In vivo imaging, In vitro testing

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Proceedings Article | 13 February 2018 Presentation + Paper

Hyperspectral imaging with near-infrared-enabled mobile phones for tissue oximetry

Jonathan Lin, Pejhman Ghassemi, Yu Chen, Joshua Pfefer

Proceedings Volume 10485, 104850C (2018) https://doi.org/10.1117/12.2290870

KEYWORDS: Cell phones, Charge-coupled devices, Cameras, Oximetry, Absorbance, Near infrared, Blood, Hyperspectral imaging, Tissues

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Hyperspectral reflectance imaging (HRI) is an emerging clinical tool for characterizing spatial and temporal variations in blood perfusion and oxygenation for applications such as burn assessment, wound healing, retinal exams and intraoperative tissue viability assessment. Since clinical HRI-based oximeters often use near-infrared (NIR) light, NIR-enabled mobile phones may provide a useful platform for future point-of-care devices. Furthermore, quantitative NIR imaging on mobile phones may dramatically increase the availability and accessibility of medical diagnostics for low-resource settings. We have evaluated the potential for phone-based NIR oximetry imaging and elucidated factors affecting performance using devices from two different manufacturers, as well as a scientific CCD. A broadband light source and liquid crystal tunable filter were used for imaging at 10 nm bands from 650 to 1000 nm. Spectral sensitivity measurements indicated that mobile phones with standard NIR blocking filters had minimal response beyond 700 nm, whereas one modified phone showed sensitivity to 800 nm and another to 1000 nm. Red pixel channels showed the greatest sensitivity up to 800 nm, whereas all channels provided essentially equivalent sensitivity at longer wavelengths. Referencing of blood oxygenation levels was performed with a CO-oximeter. HRI measurements were performed using cuvettes filled with hemoglobin solutions of different oxygen saturation levels. Good agreement between absorbance spectra measured with mobile phone and a CCD cameras were seen for wavelengths below 900 nm. Saturation estimates showed root-mean-squared-errors of 5.2% and 4.5% for the CCD and phone, respectively. Overall, this work provides strong evidence of the potential for mobile phones to provide quantitative spectral imaging in the NIR for applications such as oximetry, and generates practical insights into factors that impact performance as well as test methods for performance assessment.

SPIE Journal Paper | 1 December 2017 Open Access

Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease

Bohan Wang, Hsing-Wen Wang, Hengchang Guo, Erik Anderson, Qinggong Tang, Tong Tong Wu, Reuben Falola, Tikina Smith, Peter M. Andrews, Yu Chen

JBO, Vol. 22, Issue 12, 121706, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121706

KEYWORDS: Kidney, Optical coherence tomography, Computer aided diagnosis and therapy, Image segmentation, Databases, Image processing, Solid modeling, Image classification, Feature extraction, Tissues

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Proceedings Article | 1 May 2017 Presentation

Intra-opeartive OCT imaging and sensing devices for clinical translation (Conference Presentation)

Yu Chen

Proceedings Volume 10060, 100600C (2017) https://doi.org/10.1117/12.2256670

KEYWORDS: Optical coherence tomography, Brain, Imaging devices, Biopsy, Optical imaging, Electrodes, In vivo imaging, Integrated optics, Doppler tomography, Optical sensing

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Proceedings Article | 20 April 2017 Presentation

Cerebral NIRS performance testing with molded and 3D-printed phantoms (Conference Presentation)

Jianting Wang, Stanley Huang, Yu Chen, Cristin Welle, T. Joshua Pfefer

Proceedings Volume 10056, 1005608 (2017) https://doi.org/10.1117/12.2254901

KEYWORDS: Tissues, Traumatic brain injury, Photopolymers, Titanium, Near infrared spectroscopy, Optical properties, Standards development, Biomedical optics, Point-of-care devices

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Proceedings Article | 19 April 2017 Presentation

Real-time monitoring the distribution of antibody-photo-absorber conjugates during photoimmunotherapy in vivo (Conference Presentation)

Qinggong Tang, Jonathan Lin, Tadanobu Nagaya, Yi Liu, Hisataka Kobayashi, Yu Chen

Proceedings Volume 10047, 100470V (2017) https://doi.org/10.1117/12.2253355

KEYWORDS: Tumors, Luminescence, Imaging systems, In vivo imaging, Cancer, Near infrared, Cell death, Photoimmunotherapy, Monoclonal antibody therapy, Monoclonal antibodies

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Proceedings Article | 19 April 2017 Presentation

Near-infrared fluorescence imaging with a mobile phone (Conference Presentation)

Pejhman Ghassemi, Bohan Wang, Jianting Wang, Quanzeng Wang, Yu Chen, T. Joshua Pfefer

Proceedings Volume 10055, 100550Q (2017) https://doi.org/10.1117/12.2253878

KEYWORDS: Optical filters, Charge-coupled devices, Luminescence, Near infrared, Cell phones, Cameras, Biomedical optics, Spatial resolution, Image filtering, Imaging systems

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SPIE Journal Paper | 3 April 2017 Open Access

Special Section Guest Editorial: Brain Mapping and Therapeutics

Shouleh Nikzad, Yu Chen, Vassiliy Tsytsarev, Babak Kateb, Warren Grundfest

NPh, Vol. 4, Issue 01, 011001, (April 2017) https://doi.org/10.1117/12.10.1117/1.NPh.4.1.011001

KEYWORDS: Brain, Brain mapping, Neurophotonics, Neuroimaging, Tissue optics, Medicine, Sensors, Neuroscience, Optical coherence tomography, Tumors

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Proceedings Article | 21 March 2017 Presentation + Paper

Near-infrared fluorescence image quality test methods for standardized performance evaluation

Udayakumar Kanniyappan, Bohan Wang, Charles Yang, Pejhman Ghassemi, Quanzeng Wang, Yu Chen, Joshua Pfefer

Proceedings Volume 10056, 100560J (2017) https://doi.org/10.1117/12.2255867

KEYWORDS: Imaging systems, Luminescence, Image quality standards, Indocyanine green, Standards development, Quantum dots, Spatial resolution, Image quality, Quality testing methods, Near infrared, Solids, Liquids, Epoxies

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SPIE Journal Paper | 14 November 2016 Open Access

Review of mesoscopic optical tomography for depth-resolved imaging of hemodynamic changes and neural activities

Qinggong Tang, Jonathan Lin, Vassiliy Tsytsarev, Reha Erzurumlu, Yi Liu, Yu Chen

NPh, Vol. 4, Issue 01, 011009, (November 2016) https://doi.org/10.1117/12.10.1117/1.NPh.4.1.011009

KEYWORDS: Luminescence, Sensors, Optical tomography, Absorption, Imaging systems, Hemodynamics, Tissue optics, 3D image processing, Brain, Signal detection

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Proceedings Article | 27 April 2016 Presentation

Using optical coherence tomography (OCT) to evaluate the status of human donor kidneys (Conference Presentation)

Peter Andrews, Brandon Konkel, Erik Anderson, Matthew Stein, Matthew Cooper, Jennifer Verbesey, Seyed Ghasemian, Yu Chen

Proceedings Volume 9689, 96891O (2016) https://doi.org/10.1117/12.2217010

KEYWORDS: Kidney, Optical coherence tomography, Surgery, Clinical trials, Diagnostics, Current controlled current source

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Proceedings Article | 26 April 2016 Presentation

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography (Conference Presentation)

Qinggong Tang, Aaron Frank, Jianting Wang, Chao-wei Chen, Lily Jin, Jon Lin, Joanne Chan, Yu Chen

Proceedings Volume 9701, 97010I (2016) https://doi.org/10.1117/12.2211217

KEYWORDS: Cancer, Optical coherence tomography, Luminescence, Optical tomography, Colon, Tumors, Tissues, Molecular imaging, Multimodal imaging, Oncology

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Proceedings Article | 21 March 2016 Paper

Elucidation of the role of biological factors and device design in cerebral NIRS using an in vivo hematoma model based on high-intensity focused ultrasound

Jianting Wang, Stanley Huang, Matthew Myers, Yu Chen, Cristin Welle, Joshua Pfefer

Proceedings Volume 9690, 96900U (2016) https://doi.org/10.1117/12.2217771

KEYWORDS: Near infrared spectroscopy, Ultrasonography, Traumatic brain injury, Blood, Transducers, Skin, Brain, Skull, Head, Signal detection

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Proceedings Article | 21 March 2016 Presentation + Paper

OCT imaging of myocardium extending to pulmonary vein

Zhifang Li, Timm Dickfeld, Qinggong Tang, Bohan Wang, Yu Chen

Proceedings Volume 9689, 96893A (2016) https://doi.org/10.1117/12.2220393

KEYWORDS: Optical coherence tomography, Veins, Tissues, Photovoltaics, Natural surfaces, Atrial fibrillation, Visualization, Structured optical fibers, Refractive index, Tissue optics

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Proceedings Article | 18 March 2016 Presentation + Paper

Performance evaluation of CCD- and mobile-phone-based near-infrared fluorescence imaging systems with molded and 3D-printed phantoms

Bohan Wang, Pejhman Ghassemi, Jianting Wang, Quanzeng Wang, Yu Chen, Joshua Pfefer

Proceedings Volume 9700, 970006 (2016) https://doi.org/10.1117/12.2220412

KEYWORDS: Imaging systems, Luminescence, Near infrared, Standards development, CCD cameras, Cell phones, 3D printing, Tissues, Image quality standards, Biomedical optics, Image quality, Scattering, Cameras, Absorption

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Proceedings Article | 18 March 2016 Presentation + Paper

Quantitative assessment of hyperspectral imaging in detection of plasmonic nanoparticles: a modified contrast-detail analysis approach

Jianting Wang, Yu Chen, T. Joshua Pfefer

Proceedings Volume 9700, 97000D (2016) https://doi.org/10.1117/12.2214750

KEYWORDS: Nanoparticles, Hyperspectral imaging, Plasmonics, Biological research, Reflectivity, Tissues, Imaging devices, Gold, Cancer, Absorption, Imaging systems, Biomedical optics, Neodymium, Ions

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SPIE Journal Paper | 10 December 2015 Open Access

Rapid prototyping of biomimetic vascular phantoms for hyperspectral reflectance imaging

Pejhman Ghassemi, Jianting Wang, Anthony Melchiorri, Jessica Ramella-Roman, Scott Mathews, James Coburn, Brian Sorg, Yu Chen, T. Joshua Pfefer

JBO, Vol. 20, Issue 12, 121312, (December 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.12.121312

KEYWORDS: Printing, 3D printing, Reflectivity, Biomimetics, Tissues, Yeast, Rapid manufacturing, 3D image processing, Hyperspectral imaging, Chromophores

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Proceedings Article | 19 March 2015 Paper

Optical coherence tomography (OCT) of a murine model of chronic kidney disease

Hsing-Wen Wang, Hengchang Guo, Peter Andrews, Erik Anderson, Y Chen

Proceedings Volume 9417, 94170T (2015) https://doi.org/10.1117/12.2082167

KEYWORDS: Optical coherence tomography, Kidney, Image segmentation, Doppler tomography, Blood circulation, In vivo imaging, Imaging systems, Phase modulation, Biopsy, Coherence imaging

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Proceedings Article | 11 March 2015 Paper

Oximetry system performance assessment with POM (acetal) phantoms incorporating hemoglobin calibration standards and customized saturation levels

Hyounguk Jang, Karam Singh, Hsing-Wen Wang, T. Pfefer, Yu Chen

Proceedings Volume 9315, 931503 (2015) https://doi.org/10.1117/12.2087095

KEYWORDS: Near infrared spectroscopy, Tissues, Absorbance, Optical properties, Oximetry, Spectrophotometry, Fiber optics, Tissue optics, Solids, Light sources

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Proceedings Article | 6 March 2015 Paper

3D printed biomimetic vascular phantoms for assessment of hyperspectral imaging systems

Jianting Wang, Pejhman Ghassemi, Anthony Melchiorri, Jessica Ramella-Roman, Scott Mathews, James Coburn, Brian Sorg, Yu Chen, Joshua Pfefer

Proceedings Volume 9325, 932508 (2015) https://doi.org/10.1117/12.2084720

KEYWORDS: 3D printing, Imaging systems, 3D image processing, Reflectivity, Printing, Yeast, Hyperspectral imaging, Image segmentation, Tissues, Oximetry

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SPIE Journal Paper | 24 September 2014 Open Access

Real-time monitoring of hemodynamic changes in tumor vessels during photoimmunotherapy using optical coherence tomography

Chia-Pin Liang, Takahito Nakajima, Rira Watanabe, Kazuhide Sato, Peter Choyke, Yu Chen, Hisataka Kobayashi

JBO, Vol. 19, Issue 09, 098004, (September 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.9.098004

KEYWORDS: Tumors, Blood, Optical coherence tomography, Blood vessels, Photoimmunotherapy, Tissues, Hemodynamics, Near infrared, Cancer, In vivo imaging

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Proceedings Article | 22 May 2014 Paper

Quantitative analysis of low contrast detectability in optical coherence tomography

Nicholas Woolsey, Hsing-Wen Wang, Anant Agrawal, Jianting Wang, Chia-Pin Liang, Yu Chen, Joshua Pfefer

Proceedings Volume 9107, 91070C (2014) https://doi.org/10.1117/12.2053721

KEYWORDS: Optical coherence tomography, Scattering, Standards development, Tissues, Signal detection, Quantitative analysis, Medical imaging modalities, Signal attenuation, Visualization, Image resolution

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Proceedings Article | 10 March 2014 Paper

Quantitative assessment of biophotonic imaging system performance with phantoms fabricated by rapid prototyping

Jianting Wang, James Coburn, Nicholas Woolsey, Chia-Pin Liang, Jessica Ramella-Roman, Yu Chen, Joshua Pfefer

Proceedings Volume 8936, 89360M (2014) https://doi.org/10.1117/12.2044089

KEYWORDS: Printing, 3D printing, Optical coherence tomography, Imaging systems, Biomedical optics, Scattering, Reflectivity, Optical properties, Absorption, Rapid manufacturing

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SPIE Journal Paper | 1 October 2013 Open Access

Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes

Hengchang Guo, Hossein Aleyasin, Scott Howard, Bryan Dickinson, Vivian Lin, Chris Xu, Yu Chen, Rajiv Ratan, Renee Haskew-Layton

JBO, Vol. 18, Issue 10, 106002, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.106002

KEYWORDS: Luminescence, Two photon imaging, Hydrogen, Absorption, Oxygen, Sapphire lasers, Confocal microscopy, Medical research, Molecules, In vivo imaging

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Proceedings Article | 31 May 2013 Paper

Characterization and application of 3D-printed phantoms for biophotonic imaging

Jianting Wang, James Coburn, Chia-Pin Liang, Nicholas Woolsey, Du Le, Jessica Ramella-Roman, Yu Chen, Joshua Pfefer

Proceedings Volume 8719, 87190Y (2013) https://doi.org/10.1117/12.2018285

KEYWORDS: Absorption, Reflectivity, 3D printing, Biomedical optics, Printing, Optical coherence tomography, Tissues, Optical properties, Scattering, Hyperspectral imaging

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SPIE Journal Paper | 22 April 2013 Open Access

Concurrent multiscale imaging with magnetic resonance imaging and optical coherence tomography

Chia-Pin Liang, Bo Yang, Il Kyoon Kim, George Makris, Jaydev Desai, Rao Gullapalli, Yu Chen

JBO, Vol. 18, Issue 04, 046015, (April 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.4.046015

KEYWORDS: Optical coherence tomography, Magnetic resonance imaging, Tissues, Brain, Neuroimaging, Video, Thalamus, Signal attenuation, Breast, Imaging systems

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Proceedings Article | 13 March 2013 Paper

Multi-system comparison of optical coherence tomography performance with point spread function phantoms

Joshua Pfefer, Anthony Fouad, Chao-Wei Chen, Wei Gong, Peter Tomlins, Peter Woolliams, Rebekah Drezek, Anant Agrawal, Yu Chen

Proceedings Volume 8573, 85730C (2013) https://doi.org/10.1117/12.2007005

KEYWORDS: Point spread functions, Optical coherence tomography, Particles, Silica, Spatial resolution, Gold, Image quality standards, Optical resolution, Image quality, Backscatter

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Proceedings Article | 8 March 2013 Paper

Using OCT to predict post-transplant renal function

Peter Andrews, Yu Chen, Jeremiah Wierwille, Daniel Joh, Peter Alexandrov, Derek Rogalsky, Patrick Moody, Allen Chen, Matthew Cooper, Jennifer Verbesey, Wei Gong, Hsing-Wen Wang

Proceedings Volume 8565, 856511 (2013) https://doi.org/10.1117/12.2005962

KEYWORDS: Kidney, Optical coherence tomography, Transplantation, Tissue optics, Imaging systems, Biopsy, Blood circulation, In vivo imaging, Objectives, Surgery

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Proceedings Article | 16 May 2012 Paper

Nondestructive imaging of stem cell in 3D scaffold

Chao-Wei Chen, Andrew Yeatts, John Fisher, Yu Chen

Proceedings Volume 8367, 836706 (2012) https://doi.org/10.1117/12.920458

KEYWORDS: Stem cells, 3D image processing, Imaging systems, Capillaries, Tissues, Nondestructive evaluation, Optical tomography, Regenerative medicine, Tissue engineering, Molecular interactions

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Proceedings Article | 11 February 2011 Paper

Study on blood flow pulsation using laser speckle contrast imaging

Shuai Yuan, Yu Chen, Chrysanthe Preza, Cha-Min Tang

Proceedings Volume 7898, 78980G (2011) https://doi.org/10.1117/12.875681

KEYWORDS: Laser speckle contrast imaging, Blood circulation, Speckle, Heart, Biomedical optics, Animal model studies, Blood, Physiology, Liquids, Speckle pattern

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Proceedings Article | 23 February 2010 Paper

Noise analysis in laser speckle contrast imaging

Shuai Yuan, Yu Chen, Andrew Dunn, David Boas

Proceedings Volume 7563, 75630J (2010) https://doi.org/10.1117/12.842458

KEYWORDS: Laser speckle contrast imaging, Speckle, Physiology, Biomedical optics, Mathematical modeling, Blood circulation, Heart, Animal model studies, Statistical analysis, Statistical modeling

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Proceedings Article | 23 February 2010 Paper

Correlation of morphological and molecular parameters for colon cancer

Shuai Yuan, Celeste Roney, Qian Li, James Jiang, Alex Cable, Ronald Summers, Yu Chen

Proceedings Volume 7555, 75551F (2010) https://doi.org/10.1117/12.842599

KEYWORDS: Optical coherence tomography, Luminescence, Scattering, Tissues, Colorectal cancer, Tumors, Cancer, Error control coding, Molecular imaging, Colon

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Proceedings Article | 11 February 2010 Paper

Investigation of pore structure and cell distribution in EH-PEG hydrogel scaffold using optical coherence tomography and fluorescence microscopy

Chao-Wei Chen, Martha Betz, John Fisher, Andrew Paek, James Jiang, Hongzhou Ma, Alex Cable, Yu Chen

Proceedings Volume 7566, 756603 (2010) https://doi.org/10.1117/12.840809

KEYWORDS: Optical coherence tomography, Image processing, Luminescence, Microscopy, Fermium, Frequency modulation, 3D image processing, Image segmentation, Algorithm development, Visualization

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Proceedings Article | 25 November 2009 Paper

Multi-modality optical tomography for simultaneous morphological and molecular imaging

Shuai Yuan, Qian Li, Yu Chen

Proceedings Volume 7634, 763408 (2009) https://doi.org/10.1117/12.852307

KEYWORDS: Optical coherence tomography, Luminescence, Tissues, Sensors, Imaging systems, Signal detection, Capillaries, Molecular imaging, Optical tomography, Image resolution

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Proceedings Article | 25 February 2009 Paper

Combining optical coherence tomography with fluorescence molecular imaging: towards simultaneous morphology and molecular imaging

Shuai Yuan, Michael Lai, Celeste Roney, James Jiang, Qian Li, Hongzhou Ma, Alex Cable, Ronald Summers, Yu Chen

Proceedings Volume 7169, 71690O (2009) https://doi.org/10.1117/12.808505

KEYWORDS: Optical coherence tomography, Luminescence, Tissues, Imaging systems, Molecular imaging, Scattering, Capillaries, Colon, Colorectal cancer, Image resolution

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Proceedings Article | 5 March 2008 Paper

In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

Desmond Adler, Yu Chen, Robert Huber, Joseph Schmitt, James Connolly, James Fujimoto

Proceedings Volume 6847, 684708 (2008) https://doi.org/10.1117/12.761850

KEYWORDS: Optical coherence tomography, Data acquisition, Imaging systems, Colon, In vivo imaging, Endomicroscopy, 3D acquisition, Tissues, 3D image processing, Endoscopy

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SPIE Journal Paper | 1 May 2007 Open Access

High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo

Yu Chen, Peter Andrews, Aaron Aguirre, Joseph Schmitt, James Fujimoto

JBO, Vol. 12, Issue 03, 034008, (May 2007) https://doi.org/10.1117/12.10.1117/1.2736421

KEYWORDS: Optical coherence tomography, Kidney, 3D image processing, Tissues, Coherence imaging, Ischemia, Transplantation, Mercury, Imaging systems, Polarization

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Proceedings Article | 15 March 2007 Paper

Investigation of the use of iodinated contrast agent in a proposed flat-panel CT mammography system

Clay Didier, Stephen Glick, Xing Gong, Yu Chen, Mufeed Mahd

Proceedings Volume 6510, 651034 (2007) https://doi.org/10.1117/12.713837

KEYWORDS: Tumors, Signal attenuation, Breast, Iodine, X-rays, Mammography, Tissues, X-ray computed tomography, Scattering, Sensors

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In considering a breast CT system, it is important to note that the spectral attenuation profile of a tumor is very similar to that of fibro-glandular tissue. Preliminary evidence based on imaging breast specimens suggest that the CT number of a malignant breast tumor is very similar to that of surrounding fibro-glandular tissue. Therefore, it is expected that radiologists will probably rely more on tumor morphology to distinguish a malignant tumor from fibro-glandular tissue than an increase in contrast per se. Previous studies have shown that iodinated contrast agents can increase the effective attenuation coefficient yielded by a breast tumor thereby providing increased CT tumor contrast. In order to characterize how the intravenous administration of an iodinated contrast agent can affect the performance of CT breast imaging, a computer simulation of such a system was conducted. The two primary goals of this investigation were first to determine how mean glandular dose, choice of x-ray energy spectrum, and iodine contrast agent density affect tumor detection, and second to determine what effect Compton and Rayleigh scattering have on the variability of the attenuation coefficient yielded by CT mammography. The first goal was achieved by making use of a modified version of the Bakic (Med. Phys. 2003) digital breast phantom to model the uncompressed breast, and a 0.5 cm sphere representing a breast tumor was digitally inserted into the ductal region of this phantom. Several projection sets were generated with the tumor containing various densities of iodine contrast agent, different x-ray energy spectra, and different mean glandular dosage (MGD) levels . Slices through the tumor were extracted from the reconstructions of these projections and were used in human observer studies to determine tumor detectability. The second goal was achieved by using the GATE (Geant 4 Application for Tomographic Emission) Monte-Carlo software package to compute the scattering incident on the flat panel detector for an x-ray projection, then using the aforementioned Bakic phantom, a 0.5 cm sphere representing a breast tumor attenuation and a 3.0 mg/ml of Iodinated contrast agent were inserted at various locations with varying attenuation for 100 projection sets with scatter, and 100 projections without scatter. Histograms of the resulting effective attenuation coefficients yielded by Feldkamp filtered backprojection were plotted and compared.

Proceedings Article | 7 October 2005 Paper

Cross-sectional imaging of functional activation in the rat somatosensory cortex with optical coherence tomography

A. Aguirre, Y. Chen, L. Ruvinskaya, A. Devor, D. Boas, J. Fujimoto

Proceedings Volume 5861, 58611D (2005) https://doi.org/10.1117/12.641798

KEYWORDS: Optical coherence tomography, Video microscopy, Skull, Somatosensory cortex, Hemodynamics, Scattering, Functional magnetic resonance imaging, Spatial resolution, Brain activation, Tissues

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Proceedings Article | 22 April 2005 Paper

All-fiber CW Raman continuum light source for ultrahigh resolution optical coherence tomography

Pei-Lin Hsiung, Yu Chen, N. Nishizawa, Tony Ko, James Fujimoto, Christiano de Matos, Sergei Popov, James Taylor, J. Broeng, Valentin Gapontsev

Proceedings Volume 5709, (2005) https://doi.org/10.1117/12.590800

KEYWORDS: Light sources, Optical coherence tomography, Image resolution, Raman spectroscopy, Fiber lasers, In vivo imaging, Femtosecond phenomena, Imaging systems, Tissues, Photonic crystal fibers

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Proceedings Article | 13 April 2005 Paper

Ultrahigh-resolution endoscopic optical coherence tomography for gastrointestinal imaging

Yu Chen, Paul Herz, Pei-Lin Hsiung, Aaron Aguirre, Karl Schneider, James Fujimoto, Hiroshi Mashimo, Saleem Desai, Marcos Pedrosa, Joseph Schmitt, Amanda Koski

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592609

KEYWORDS: Optical coherence tomography, Esophagus, Endoscopy, Image resolution, In vivo imaging, Tissues, Tissue optics, Chromium, Colon, Biopsy

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Proceedings Article | 1 April 2005 Paper

Ultrahigh resolution OCT imaging with a two-dimensional MEMS scanning endoscope

Aaron Aguirre, Paul Herz, Yu Chen, James Fujimoto, Wibool Piyawattanametha, Li Fan, ShuTing Hsu, Makoto Fujino, Ming Wu, Daniel Kopf

Proceedings Volume 5692, (2005) https://doi.org/10.1117/12.593143

KEYWORDS: Optical coherence tomography, Microelectromechanical systems, Endoscopes, Image resolution, Endoscopy, Mirrors, Scanners, 3D image processing, Tissues, 3D scanning

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Proceedings Article | 22 January 2005 Paper

High-resolution 3D OCT imaging with a MEMS scanning endoscope

Li Fan, Wibool Piyawattanametha, Ming Wu, Aaron Aguirre, Paul Herz, Yu Chen, James Fujimoto

Proceedings Volume 5719, (2005) https://doi.org/10.1117/12.600089

KEYWORDS: Microelectromechanical systems, Optical coherence tomography, Endoscopes, Scanners, Mirrors, Endoscopy, In vivo imaging, 3D image processing, Tissues, Collimators

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Proceedings Article | 18 January 2005 Paper

Ultrahigh-resolution endoscopic optical coherence tomography

Yu Chen, Paul Herz, Pei-Lin Hsiung, Aaron Aguirre, Hiroshi Mashimo, Saleem Desai, Macos Pedrosa, Amanda Koski, Joseph Schmitt, James Fujimoto

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.577171

KEYWORDS: Optical coherence tomography, Endoscopy, Esophagus, Image resolution, In vivo imaging, Tissues, Biopsy, Cancer, Tissue optics, Colon

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Proceedings Article | 20 August 2004 Paper

Imaging of tumor hypermetabolism with near-infrared fluorescence contrast agents

Yu Chen, Gang Zheng, Zhihong Zhang, Dana Blessington, Xavier Intes, Samuel Achilefu, Britton Chance

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578379

KEYWORDS: Tumors, Luminescence, Imaging systems, Tissues, Photons, Breast, In vivo imaging, Phased arrays, Signal detection, Near infrared

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Proceedings Article | 8 December 2003 Paper

Assessment of tumor angiogenesis using fluorescence contrast agents

Yu Chen, Qian Liu, Ping Huang, Shay Hyman, Xavier Intes, William Lee, Britton Chance

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546210

KEYWORDS: Tumors, Tissues, Luminescence, Indocyanine green, Data modeling, Animal model studies, Interference filters, Blood, Tissue optics, Optical imaging

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Proceedings Article | 8 December 2003 Paper

Low-frequency phased-array 2D fluorescence localization in breast cancer detection

Qian Liu, Yu Chen, Britton Chance, Qingming Luo

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546147

KEYWORDS: Luminescence, Breast cancer, Signal detection, Absorption, Phased arrays, Sensors, Light emitting diodes, Light sources, Breast, Modulation

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Proceedings Article | 29 July 2003 Paper

Determination of subsurface tumor localization in animal models with near-infrared (NIR) fluorescence imaging

Yu Chen, Dana Blessington, Zhihong Zhang, Qian Liu, Lanlan Zhou, Chenpeng Mu, Xavier Intes, Samuel Achilefu, Hui Li, Min Zhang, Gang Zheng, Britton Chance

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478187

KEYWORDS: Tumors, Luminescence, Animal model studies, Scattering, Near infrared, Phased arrays, In vivo imaging, Breast, Signal detection, Imaging systems

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Proceedings Article | 29 July 2003 Paper

Handheld low-frequency phased array near-infrared (NIR) breast cancer localizer

Qian Liu, Yu Chen, Qingming Luo

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.503168

KEYWORDS: Light emitting diodes, Phased arrays, Signal detection, Sensors, Breast cancer, Tumors, Scattering, Modulation, Near infrared, Oscillators

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SPIE Journal Paper | 1 October 2002 Open Access

Analysis on performance and optimization of frequency-domain near-infrared instruments

Tao Tu, Yu Chen, Zhang Jun, Xavier Intes, Britton Chance

JBO, Vol. 7, Issue 04, (October 2002) https://doi.org/10.1117/12.10.1117/1.1501562

KEYWORDS: Signal to noise ratio, Instrument modeling, Signal detection, Modulation, Signal attenuation, Interference (communication), Diffusion, Sensors, Performance modeling, Light

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Proceedings Article | 12 September 2002 Paper

Phase cancellation system for tumor imaging using targeted fluorescent contrast agents

Yu Chen, Lanlan Zhou, Chenpeng Mu, Xavier Intes, Samuel Achilefu, Britton Chance

Proceedings Volume 4916, (2002) https://doi.org/10.1117/12.482934

KEYWORDS: Tumors, Imaging systems, Phased arrays, Luminescence, Tissues, Signal detection, Phase only filters, Modulation, Phase measurement, Scattering

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Proceedings Article | 12 April 2002 Paper

Diffuse optical tomography using dual-interfering source

Yu Chen, Chenpeng Mu, Xavier Intes, Britton Chance

Proceedings Volume 4536, (2002) https://doi.org/10.1117/12.462559

KEYWORDS: Sensors, Phased arrays, Absorption, Modulation, Imaging systems, Image restoration, Diffuse optical tomography, Tomography, Scattering, Signal detection

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Proceedings Article | 29 June 2001 Paper

Detection sensitivity and optimization of a phased-array system

Yu Chen, Xavier Intes, Shuoming Zhou, Chenpeng Mu, Monica Holboke, Arjun Yodh, Britton Chance

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434492

KEYWORDS: Absorption, Phased arrays, Scattering, Signal detection, Signal to noise ratio, Phase shift keying, Interference (communication), Diffusion, Modulation, Tissue optics

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SPIE Journal Paper | 1 April 2000 Open Access

Preliminary evaluation of dual wavelength phased array imaging on neonatal brain function

Yu Chen, Shuoming Zhou, Chunhua Xie, Shoko Nioka, Maria Delivoria-Papadopoulos, Endla Anday, Britton Chance

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429986

KEYWORDS: Brain, Blood, Phased arrays, Imaging systems, Sensors, Neuroimaging, Imaging arrays, Phase shifts, Light, Scattering

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Proceedings Article | 15 July 1999 Paper

Portable dual-wavelength amplitude cancellation image system for the determination of human breast tumor

Shuoming Zhou, Yu Chen, Q. Zou, Shoko Nioka, Xingde Li, L. Pfaff, Clay Cowan, Britton Chance

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356861

KEYWORDS: Blood, Breast, Tumors, Imaging systems, Sensors, Breast cancer, Tissues, Absorption, Cancer, Silicon

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Proceedings Article | 15 July 1999 Paper

Novel portable system for neonatal brain imaging

Yu Chen, Shuoming Zhou, Shoko Nioka, Britton Chance, Maria Delivoria-Papadopoulos, Endla Anday

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356817

KEYWORDS: Brain, Phased arrays, Blood, Imaging systems, Phase modulation, Neuroimaging, Sensors, Brain imaging, Functional imaging, Absorption

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Proceedings Article | 4 March 1999 Paper

Novel optical system for neonatal brain imaging

Yu Chen, Shuoming Zhou, Shoko Nioka, Britton Chance, Endla Anday, Sudha Ravishankar, Maria Delivoria-Papadopoulos

Proceedings Volume 3726, (1999) https://doi.org/10.1117/12.341433

KEYWORDS: Brain, Phased arrays, Blood, Neuroimaging, Brain imaging, Imaging systems, Sensors, Brain activation, Functional imaging, Phase shifts

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Showing 5 of 75 publications

Conference Committee Involvement (45)

Optics in Health Care and Biomedical Optics XV

11 October 2025 | Beijing, China

Neural Imaging and Sensing 2025

27 January 2025 | San Francisco, California, United States

Multimodal Biomedical Imaging XX

25 January 2025 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics XIV

12 October 2024 | Nantong, Jiangsu, China

Neural Imaging and Sensing 2024

27 January 2024 | San Francisco, California, United States

Multimodal Biomedical Imaging XIX

27 January 2024 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics XIII

14 October 2023 | Beijing, China

Neural Imaging and Sensing 2023

30 January 2023 | San Francisco, California, United States

Multimodal Biomedical Imaging XVIII

28 January 2023 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics XII

5 December 2022 | Online Only, China

Neural Imaging and Sensing 2022

24 January 2022 | San Francisco, California, United States

Multimodal Biomedical Imaging XVII

22 January 2022 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics XI

10 October 2021 | Nantong, JS, China

Multimodal Biomedical Imaging XVI

6 March 2021 | Online Only, California, United States

Neural Imaging and Sensing 2021

6 March 2021 | Online Only, California, United States

Optics in Health Care and Biomedical Optics X

12 October 2020 | Online Only, China

Neural Imaging and Sensing 2020

3 February 2020 | San Francisco, California, United States

Multimodal Biomedical Imaging XV

1 February 2020 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics IX

21 October 2019 | Hangzhou, China

Neural Imaging and Sensing 2019

4 February 2019 | San Francisco, California, United States

Multimodal Biomedical Imaging XIV

2 February 2019 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics VIII

11 October 2018 | Beijing, China

Neural Imaging and Sensing 2018

29 January 2018 | San Francisco, California, United States

Multimodal Biomedical Imaging XIII

27 January 2018 | San Francisco, California, United States

Neural Imaging and Sensing

30 January 2017 | San Francisco, California, United States

Multimodal Biomedical Imaging XII

28 January 2017 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics VII

12 October 2016 | Beijing, China

Neural Imaging and Sensing

15 February 2016 | San Francisco, California, United States

Multimodal Biomedical Imaging XI

13 February 2016 | San Francisco, California, United States

Clinical and Biomedical Spectroscopy and Imaging IV

22 June 2015 | Munich, Germany

Biomedical Applications in Molecular, Structural, and Functional Imaging

24 February 2015 | Orlando, Florida, United States

Neurophotonics

9 February 2015 | San Francisco, California, United States

Multimodal Biomedical Imaging X

7 February 2015 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics VI

9 October 2014 | Beijing, China

Biomedical Applications in Molecular, Structural, and Functional Imaging

16 February 2014 | San Diego, California, United States

Neurophotonics

3 February 2014 | San Francisco, California, United States

Multimodal Biomedical Imaging IX

1 February 2014 | San Francisco, California, United States

Clinical and Biomedical Spectroscopy and Imaging III

12 May 2013 | Munich, Germany

Biomedical Applications in Molecular, Structural, and Functional Imaging

11 February 2013 | Lake Buena Vista (Orlando Area), Florida, United States

Multimodal Biomedical Imaging VIII

2 February 2013 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics V

5 November 2012 | Beijing, China

Biomedical Applications in Molecular, Structural, and Functional Imaging

5 February 2012 | San Diego, California, United States

Biomedical Applications in Molecular, Structural, and Functional Imaging

13 February 2011 | Lake Buena Vista (Orlando), Florida, United States

Multimodal Biomedical Imaging VI

22 January 2011 | San Francisco, California, United States

Biomedical Applications in Molecular, Structural, and Functional Imaging

14 February 2010 | San Diego, California, United States

Showing 5 of 45 Conference Committees

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