Dr. Marco Renna Profile

Dr. Marco Renna

at Athinoula A. Martinos Ctr for Biomedical Imaging

SPIE Involvement:

Author

Publications (25)

Proceedings Article | 13 March 2024 Presentation

Presentation

FlexNIRS: current applications and latest developments of the open-source wireless wearable oximeter for cerebral health tracking

Marco Renna, Kuan-Cheng Wu, John Sunwoo, Alyssa Martin, Zachary Starkweather, Mitchell Robinson, Nikola Otic, Paul Beach, Mehrdad Dadgostar, Zahra Einalou, Stefan Carp, David Salat, Maria Angela Franceschini

Proceedings Volume PC12850, PC128500C (2024) https://doi.org/10.1117/12.3003292

KEYWORDS: Oximeters, Wireless communications, Wearable devices, Tissues, Spectroscopes, Signal intensity, Sampling rates, Photodiodes, Oxygen, Near infrared spectroscopy

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Proceedings Article | 13 March 2024 Presentation

Presentation

Depth-enhanced diffuse correlation spectroscopy enabled by coherent gain

Mitchell Robinson, Marco Renna, Stefan Carp, Maria Angela Franceschini

Proceedings Volume PC12841, PC128410C (2024) https://doi.org/10.1117/12.3003352

KEYWORDS: Spectroscopy, Blood circulation, Tissues, Signal detection, Laser sources, Scattered light, Photons, Laser interferometry, Tissue optics, Time metrology

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Proceedings Article | 13 March 2024 Presentation

Presentation

Wearable monitoring of water content variation in peripheral edema

So Hyun Chung, Marco Renna, Maria-Angela Franceschini, Stefan Carp

Proceedings Volume PC12838, PC1283802 (2024) https://doi.org/10.1117/12.3001723

KEYWORDS: Water content, Near infrared spectroscopy, Continuous wave operation, Tissues, Simulations, Prototyping, Lymphatic system, Wearable devices, Vascular diseases, Tissue optics

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Proceedings Article | 13 March 2024 Presentation

Presentation

A 256-channel SPAD detector for time-gated fNIRS and DCS

Jonathan Richardson, Tom Cheng, George Jordy, Matthew Stamplis, Ana-Maria Mandrila Vaca, Michael Bradshaw, Erik Duerr, Marco Renna, Mitchell Robinson, Stefan Carp, Maria-Angela Franceschini

Proceedings Volume PC12828, PC128280E (2024) https://doi.org/10.1117/12.3003159

KEYWORDS: Readout integrated circuits, Silicon, Near infrared spectroscopy, Windows, Spectroscopy, Photons, Imaging spectroscopy, Functional imaging, Field programmable gate arrays, Brain

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Proceedings Article | 12 March 2024 Presentation + Paper

Presentation + Paper

Camera selection for speckle contrast optical spectroscopy and validation against diffuse correlation spectroscopy

Tom Cheng, Byungchan Kim, Bernhard Zimmermann, Mitchell Robinson, Marco Renna, Stefan Carp, Maria Angela Franceschini, David Boas, Xiaojun Cheng

Proceedings Volume 12841, 1284105 (2024) https://doi.org/10.1117/12.3000411

KEYWORDS: Diffuse optical spectroscopy, Temperature control, Cerebral blood flow, Fluctuations and noise, Signal intensity, Cameras, Signal to noise ratio, Quantum reading, Speckle, Spectroscopy, Optical spectroscopy, Liquids, Quantum noise, Interference (communication), CMOS cameras

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SPIE Journal Paper | 27 January 2024 Open Access

Open Access

Comparing the performance potential of speckle contrast optical spectroscopy and diffuse correlation spectroscopy for cerebral blood flow monitoring using Monte Carlo simulations in realistic head geometries

Mitchell Robinson, Tom Cheng, Marco Renna, Melissa Wu, Byungchan Kim, Xiaojun Cheng, David Boas, Maria Angela Franceschini, Stefan Carp

NPh, Vol. 11, Issue 01, 015004, (January 2024) https://doi.org/10.1117/12.10.1117/1.NPh.11.1.015004

KEYWORDS: Speckle, Monte Carlo methods, Sensors, Cameras, Pulsed laser operation, Light sources and illumination, Neurophotonics, Tissues, Signal to noise ratio, Cerebral blood flow

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SignificanceThe non-invasive measurement of cerebral blood flow based on diffuse optical techniques has seen increased interest as a research tool for cerebral perfusion monitoring in critical care and functional brain imaging. Diffuse correlation spectroscopy (DCS) and speckle contrast optical spectroscopy (SCOS) are two such techniques that measure complementary aspects of the fluctuating intensity signal, with DCS quantifying the temporal fluctuations of the signal and SCOS quantifying the spatial blurring of a speckle pattern. With the increasing interest in the use of these techniques, a thorough comparison would inform new adopters of the benefits of each technique.AimWe systematically evaluate the performance of DCS and SCOS for the measurement of cerebral blood flow.ApproachMonte Carlo simulations of dynamic light scattering in an MRI-derived head model were performed. For both DCS and SCOS, estimates of sensitivity to cerebral blood flow changes, coefficient of variation of the measured blood flow, and the contrast-to-noise ratio of the measurement to the cerebral perfusion signal were calculated. By varying complementary aspects of data collection between the two methods, we investigated the performance benefits of different measurement strategies, including altering the number of modes per optical detector, the integration time/fitting time of the speckle measurement, and the laser source delivery strategy.ResultsThrough comparison across these metrics with simulated detectors having realistic noise properties, we determine several guiding principles for the optimization of these techniques and report the performance comparison between the two over a range of measurement properties and tissue geometries. We find that SCOS outperforms DCS in terms of contrast-to-noise ratio for the cerebral blood flow signal in the ideal case simulated here but note that SCOS requires careful experimental calibrations to ensure accurate measurements of cerebral blood flow.ConclusionWe provide design principles by which to evaluate the development of DCS and SCOS systems for their use in the measurement of cerebral blood flow.

SPIE Journal Paper | 6 September 2023 Open Access

Open Access

Enhancing diffuse correlation spectroscopy pulsatile cerebral blood flow signal with near-infrared spectroscopy photoplethysmography

Kuan Cheng Wu, Alyssa Martin, Marco Renna, Mitchell Robinson, Nisan Ozana, Stefan A. Carp, Maria Angela Franceschini

NPh, Vol. 10, Issue 03, 035008, (September 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.3.035008

KEYWORDS: Near infrared spectroscopy, Signal to noise ratio, Cerebral blood flow, Blood circulation, Spectroscopy, Blood, Oxygenation, Neurophotonics, Resistance, Sampling rates

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Proceedings Article | 15 June 2023 Presentation

Presentation

A 256-channel SPAD detector for time-gated fNIRS and DCS

Jonathan Richardson, Tom Cheng, Marco Renna, George Jordy, Matthew Stamplis, Ana-Maria Mandrilla Vacca, Michael Bradshaw, Eric Ringdahl, Brian Aull, Megan Blackwell, Erik Duerr, Mitchell Robinson, Stefan Carp, Maria-Angelica Franceschini

Proceedings Volume PC12512, PC1251208 (2023) https://doi.org/10.1117/12.2666270

KEYWORDS: Single photon avalanche diodes, Sensors, Readout integrated circuits, Silicon, Spectroscopy, Sensor performance, Photons, Near infrared spectroscopy, Functional imaging, Field programmable gate arrays

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Proceedings Article | 7 March 2023 Presentation

Presentation

Multistate time-multiplexed system for functional time-domain diffuse correlation spectroscopy with SNSPDs

Marco Renna, Zachary Starkweather, Mitchell Robinson, Nisan Ozana, Alyssa Martin, Stefan Carp, Maria Angela Franceschini

Proceedings Volume PC12376, PC123760D (2023) https://doi.org/10.1117/12.2650215

KEYWORDS: Spectroscopy, Brain, Signal to noise ratio, Blood circulation, Temporal resolution, Superconductors, Spatial resolution, Single photon detectors, Pulsed laser operation, Point spread functions

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Proceedings Article | 7 March 2023 Presentation

Presentation

Multi-wavelength multi-distance diffuse correlation spectroscopy system for assessment of premature infants’ cerebral hemodynamics

Nikola Otic, John Sunwoo, Yujing Huang, Alyssa Martin, Mitchell Robinson, Bernhard Zimmermann, Stefan Carp, Maria Franceschini, Marco Renna

Proceedings Volume PC12376, PC123760E (2023) https://doi.org/10.1117/12.2649662

KEYWORDS: Spectroscopy, Hemodynamics, Near infrared spectroscopy, Spectroscopes, Single photon detectors, Scattering, Photodetectors, Optical properties, Multiplexing, Mode conditioning cables

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SPIE Journal Paper | 15 June 2022 Open Access

Open Access

Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise

Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Michał Kacprzak, Piotr Sawosz, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu-Venkata-Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Lorenzo Frabasile, Pietro Levoni, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alberto Tosi, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

JBO, Vol. 27, Issue 07, 074716, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074716

KEYWORDS: Raster graphics, Optical properties, Diffuse optical imaging, Scattering, Imaging spectroscopy, Absorption, Tissue optics, Spectroscopes, Sensors, Oximetry

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Proceedings Article | 30 May 2022 Presentation

Presentation

Monitoring cerebral blood flow with superconducting nanowire detectors

Maria Franceschini, Nisan Ozana, Mitchell Robinson, Megan Blackwell, Stefan Carp, Marco Renna

Proceedings Volume PC12089, PC1208907 (2022) https://doi.org/10.1117/12.2622923

KEYWORDS: Superconductors, Sensors, Nanowires, Cerebral blood flow, Signal to noise ratio, Near infrared spectroscopy, Photon counting, Traumatic brain injury, Spectroscopy, Speckle

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Proceedings Article | 30 May 2022 Presentation

Presentation

A novel 32x32 InP/ InGaAs SPAD array for multi-channel time-gated diffuse correlation spectroscopy

Marco Renna, Jonathan Richardson, George Jordy, Tom Cheng, Eric Ringdahl, Mitchell Robinson, Nisan Ozana, Niyom Lue, Brian Aull, Stefan Carp, Erik Duerr, Maria Angela Franceschini, Megan Blackwell

Proceedings Volume PC12089, PC120890E (2022) https://doi.org/10.1117/12.2619112

KEYWORDS: Indium gallium arsenide, Spectroscopes, Sensors, Photons, Tissue optics, Spectroscopy, Imaging systems, Head, Brain, Single photon detectors

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Proceedings Article | 7 March 2022 Presentation

Presentation

Multimodal hybrid diffuse optics and ultrasound for screening for thyroid cancer

Pablo Fernández Esteberena, Gloria Aranda, Mauro Buttafava, Davide Contini, Lorenzo Cortese, Alberto Dalla Mora, Hamid Dehghani, Sixte de Fraguier, Felicia Hanzu, Giuseppe Lo Presti, Mireia Mora, An Nguyen Dinh, Antonio Pifferi, Marco Renna, Bogdan Rosinsky, Sabina Ruiz Janer, Mattia Squarcia, Paola Taroni, Alberto Tosi, Udo Weigel, Stanislaw Wojtkiewicz, Marta Zanoletti, Lisa Kobayashi Frisk, Turgut Durduran

Proceedings Volume PC11952, PC119520A (2022) https://doi.org/10.1117/12.2608941

KEYWORDS: Cancer, Ultrasonography, Diffuse optical imaging, Oxygen, Imaging systems, Diagnostics, Tumor growth modeling, Tissues, Tissue optics, Time resolved spectroscopy

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Proceedings Article | 2 March 2022 Presentation

Presentation

Design and characterization of a multi-channel time-gated diffuse correlation spectroscopy system at 1064nm

Marco Renna, Jonathan Richardson, George Jordy, Tom Cheng, Mitchell Robinson, Nisan Ozana, Dibbyan Mazumder, Niyom Lue, Brian Aull, Bernhard Zimmerman, Stefan Carp, Erik Duerr, David Boas, Maria Angela Franceschini, Megan Blackwell

Proceedings Volume PC11959, PC1195908 (2022) https://doi.org/10.1117/12.2610207

KEYWORDS: Spectroscopes, Spectroscopy, Sensors, Photons, Imaging systems, Head, Single photon detectors, Single photon, Sensor performance, Semiconductor lasers

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Proceedings Article | 9 December 2021 Paper

Paper

Potential for improved thyroid cancer screening aided by multi-modal clinical ultrasound and hybrid diffuse optics (LUCA platform)

Pablo Fernandez Esteberena, G. Aranda, M. Buttafava, D. Contini, L. Cortese, A. Dalla Mora, H. Dehghani, S. de Fraguier, F. Hanzu, G. Lo Presti, M. Mora Porta, A. Nguyen-Dihn, A. Pifferi, M. Renna, B. Rosinski, S. Ruiz Janer, M. Squarcia, P. Taroni, A. Tosi, U. Weigel, S. Wojtkiewicz, M. Zanoletti, T. Durduran

Proceedings Volume 11920, 119200P (2021) https://doi.org/10.1117/12.2615237

KEYWORDS: Cancer, Ultrasonography, Tumor growth modeling, Tissues, Diffuse optical imaging, Near infrared spectroscopy, Hemodynamics, Neck, Diffusion, Blood circulation

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Proceedings Article | 5 March 2021 Presentation

Presentation

Design of a skin-contact sensitive technology for biomedical sensor

Marco Renna, Adriano Peruch, Zachary Starkweather, John Sunwoo, Maria Angela Franceschini

Proceedings Volume 11633, 116330D (2021) https://doi.org/10.1117/12.2578850

KEYWORDS: Sensors, Skin, Sensor technology, Biomedical optics, Tissue optics, Near infrared spectroscopy, Spectroscopes, Safety, Polymers, Capacitors

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Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise

Sri Rama Pranav Kumar Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Giuseppe Lo Presti, Lorenzo Cortese, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Piotr Sawosz, Michal Kacprzak, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Alessandro Torricelli, Alberto Tosi, Paola Taroni, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11639, 116390F (2021) https://doi.org/10.1117/12.2578521

KEYWORDS: Raster graphics, Photonic devices, Tissue optics, Spectroscopes, Oximetry, Optical components, Mammography, Imaging spectroscopy, Functional imaging

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Proceedings Article | 5 March 2021 Presentation

Presentation

Preliminary clinical study of the potential of multi-modal optical/ultrasound LUCA platform for improved thyroid cancer screening

Lorenzo Cortese, Giuseppe Lo Presti, Pablo Fernandez Esteberena, Marta Zanoletti, Mauro Buttafava, Marco Renna, Davide Contini, Alberto Dalla Mora, Antonio Pifferi, Paola Taroni, Alberto Tosi, Gloria Aranda, Sabina Ruiz Janer, Mattia Squarcia, Felicia Hanzu, Mireia Mora Porta, Stanislaw Wojtkiewicz, Hamid Dehghani, Udo Weigel, Sixte de Fraguier, An Nguyen-Dinh, Bogdan Rosinski, Turgut Durduran

Proceedings Volume 11639, 116390L (2021) https://doi.org/10.1117/12.2577248

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Proceedings Article | 21 February 2020 Paper

Paper

A wearable time domain near infrared spectroscopy system

M. Lacerenza, M. Buttafava, M. Renna, A. Torricelli, A. Tosi, A. Dalla Mora, F. Zappa, A. Pifferi, D. Contini

Proceedings Volume 11237, 1123702 (2020) https://doi.org/10.1117/12.2544271

KEYWORDS: Brain, Near infrared spectroscopy, Hemodynamics, Optical properties, Tissue optics, Tissues, Motion measurement, Absorption, Scattering, In vivo imaging

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Proceedings Article | 11 July 2019 Paper

Paper

A wearable time domain near-infrared spectroscopy system

M. Lacerenza, M. Buttafava, M. Renna, L. Marchesi, A. Torricelli, A. Tosi, A. Dalla Mora, F. Zappa, A. Pifferi, D. Contini

Proceedings Volume 11074, 1107404 (2019) https://doi.org/10.1117/12.2527057

KEYWORDS: Near infrared spectroscopy, Hemodynamics, Brain, Absorption, Scattering, Single photon detectors, Electronics, Control systems, Solids, In vivo imaging

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Proceedings Article | 11 July 2019 Paper

Paper

Time-Resolved multi-wavelength, dual-channel system for diffuse optical spectroscopy: performance assessment

Marta Zanoletti, Marco Renna, Mauro Buttafava, Anurag Behera, Pranav Lanka, Laura Di Sieno, Alberto Dalla Mora, Alberto Tosi, Davide Contini

Proceedings Volume 11074, 110742Q (2019) https://doi.org/10.1117/12.2527049

KEYWORDS: Absorption, Time resolved spectroscopy, Scattering, Tissues, Spectroscopy, Solids, Photons, Blood, Picosecond phenomena, Signal processing

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Proceedings Article | 11 July 2019 Paper

Paper

The LUCA device: laser and ultrasound co-analyzer for thyroid nodules

L. Cortese, G. Aranda, M. Buttafava, D. Contini, A. Dalla Mora, S. de Fraguier, H. Dehghani, E. García, R. Gomis, F. Hanzu, F. Josè Torra, K. Krischak, G. Lo Presti, M. Mora, A. Pifferi, M. Renna, B. Rosinski, S. Konugolu Venkata Sekar, M. Squarcia, P. Taroni, A. Tosi, U. Weigel, S. Wojtkiewicz, M. Zanoletti, P. Zolda, T. Durduran

Proceedings Volume 11074, 1107410 (2019) https://doi.org/10.1117/12.2526607

KEYWORDS: Ultrasonography, Biomedical optics, Cancer, Time resolved spectroscopy, Scattering, Data acquisition, Blood circulation, Standards development, Sensors, Diffusion

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Proceedings Article | 30 April 2019 Paper

Paper

Sub-nanosecond gating of InGaAs/InP SPAD

Alberto Tosi, Mauro Buttafava, Marco Renna, Mirko Sanzaro

Proceedings Volume 11027, 110270B (2019) https://doi.org/10.1117/12.2525883

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Proceedings Article | 1 March 2019 Presentation + Paper

Presentation + Paper

Multi-wavelength dual-detection channel system for time-resolved near-infrared spectroscopy

Marco Renna, Mauro Buttafava, Anurag Behera, Marta Zanoletti, Laura Di Sieno, Alberto Dalla Mora, Davide Contini, Alberto Tosi

Proceedings Volume 10874, 1087408 (2019) https://doi.org/10.1117/12.2509706

KEYWORDS: Picosecond phenomena, Semiconductor lasers, Laser sources, Near infrared spectroscopy, Sensors, Optical fibers, Scattering, Field programmable gate arrays, Absorption, Pulsed laser operation

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Showing 5 of 25 publications

Conference Committee Involvement (1)

Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXII

26 January 2025 | San Francisco, California, United States

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