Dr. Lionel Hervé Profile

Dr. Lionel Hervé

Engineer-Researcher at MINATEC

SPIE Involvement:

Author

Publications (69)

Proceedings Article | 18 June 2024 Presentation

Quantitative analysis of cell culture through learning-enabled lens-free microscopy

Florian Lemarchand, Martin Alice, Lionel Hervé, Kiran Padmanabhan, Cédric Allier, Chiara Paviolo

Proceedings Volume PC12996, PC129960V (2024) https://doi.org/10.1117/12.3022160

KEYWORDS: Quantitative analysis, Microscopy, Microscopes, Detection and tracking algorithms, Neural networks, Modeling, Education and training, Biological research, Biological imaging, Algorithm development

Read Abstract +

Proceedings Article | 18 June 2024 Presentation

A bimodal fluorescence and phase microscope for time-lapse imaging of 3D multi-scattering objects

Chiara Paviolo, Sylvia Desissaire, Edgar del Llano, Marie Fackeure, Jeremy Neri, Cécile Fiche, Corinne Loeuillet, Pierre Ray, Christophe Arnoult, Kiran Padmanabhan, Lionel Hervé

Proceedings Volume PC12996, PC129960P (2024) https://doi.org/10.1117/12.3017387

Read Abstract +

Proceedings Article | 18 June 2024 Presentation

3D-printed organoid phantoms: a tool for developing quantitative phase imaging methods for highly-scattering samples

Arkadiusz Kus, Michal Ziemczonok, Cécile Fiche, Sylvia Desissaire, Clement Acquitter, Lionel Hervé, Marie Fackeure, Jeremy Neri, Wojciech Krauze, Kiran Padmanabhan, Chiara Paviolo

Proceedings Volume PC12996, PC1299607 (2024) https://doi.org/10.1117/12.3017673

KEYWORDS: Phase imaging, Biological samples, Tomography, Reconstruction algorithms, Printing, 3D metrology, Two photon polymerization, Tissues, Scattering, Refractive index

Read Abstract +

Proceedings Article | 18 June 2024 Presentation

Identifying heterogeneity in cell culture through machine learning-enabled lens-free microscopy

Martin Alice, Florian Lemarchand, Kiran Padmanabhan, Lionel Hervé, Olivier Cioni, Chiara Paviolo

Proceedings Volume PC12996, PC129960Y (2024) https://doi.org/10.1117/12.3021685

KEYWORDS: Machine learning, Microscopy, Cancer detection, Cancer, Phase reconstruction, Holography, Cell phenotyping, Algorithm development, Resistance, Image segmentation

Read Abstract +

Proceedings Article | 6 June 2024 Poster

3D fluorescence recovery by using a new algorithm implementing total variation regularization and the positivity constraint

Lionel Hervé, Stephane Bonnet, Sylvia Desissaire, Edgar del Llano, Corinne Loeuillet, Pierre Ray, Christophe Arnoult, Chiara Paviolo

Proceedings Volume PC12996, PC1299617 (2024) https://doi.org/10.1117/12.3022083

KEYWORDS: Fluorescence, 3D acquisition, Refractive index, Reconstruction algorithms, Point spread functions, Optical design, Microscopes, Image restoration, Image processing, Image deconvolution

SPIE Journal Paper | 15 June 2022 Open Access

Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise

Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Michał Kacprzak, Piotr Sawosz, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu-Venkata-Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Lorenzo Frabasile, Pietro Levoni, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alberto Tosi, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

JBO, Vol. 27, Issue 07, 074716, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074716

KEYWORDS: Raster graphics, Optical properties, Diffuse optical imaging, Scattering, Imaging spectroscopy, Absorption, Tissue optics, Spectroscopes, Sensors, Oximetry

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 30 May 2022 Presentation

From phase imaging to CNN-based quantitative representation

Cédric Allier, Lionel Hervé, Chiara Paviolo, Ondrej Mandula, Olivier Cioni, William Pierré, Kiran Padmanabhan, Francesca Andriani, Sophie Morales

Proceedings Volume PC12136, PC121360T (2022) https://doi.org/10.1117/12.2625595

KEYWORDS: Phase imaging, Microscopy, Live cell imaging, Holography, 3D image reconstruction

Read Abstract +

Proceedings Article | 30 May 2022 Presentation

3D live cell imaging of whole organoids in time-lapse using intensity diffraction tomography

William Pierré, Lionel Hervé, Cédric Allier, Sophie Morales, Sergei Grudinin, Pierre RAY, Christophe Arnoult, Magali Dhellemmes

Proceedings Volume PC12136, PC1213612 (2022) https://doi.org/10.1117/12.2625734

KEYWORDS: 3D image processing, Tomography, Live cell imaging, Diffraction, 3D modeling, 3D acquisition, Beam propagation method, 3D metrology, Spatial resolution, Scattering

Read Abstract +

Proceedings Article | 5 March 2021 Poster

Phase imaging of supracellular structures with lens-free microscopy

Romain Alata, Thomas Vourc'h, Lionel Hervé, Sophie Morales, Pascal Silberzan, Cédric Allier

Proceedings Volume 11653, 116531O (2021) https://doi.org/10.1117/12.2579651

KEYWORDS: Reconstruction algorithms, Microscopy, Phase imaging, Inverse problems, Tumors, Inverse optics, Convolutional neural networks, Neural networks, Microscopes, Imaging devices

Proceedings Article | 5 March 2021 Presentation

Deep learning framework applied to optical diffraction tomography (ODT)

William Pierré, Lionel Hervé, Cédric Allier, Sophie Morales, Sergei Grudinin, Shwetadwip Chowdhury, Laura Waller, Christophe ARNOULT, Pierre RAY, Magali Dhellemmes

Proceedings Volume 11649, 116490F (2021) https://doi.org/10.1117/12.2582361

KEYWORDS: Tomography, Optical tomography, Inverse optics, Geometrical optics, Diffraction, Refractive index, Neural networks, Multiple scattering, Physics, Light scattering

Read Abstract +

Proceedings Article | 5 March 2021 Presentation + Paper

A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise

Sri Rama Pranav Kumar Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Giuseppe Lo Presti, Lorenzo Cortese, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Piotr Sawosz, Michal Kacprzak, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Alessandro Torricelli, Alberto Tosi, Paola Taroni, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11639, 116390F (2021) https://doi.org/10.1117/12.2578521

KEYWORDS: Raster graphics, Photonic devices, Tissue optics, Spectroscopes, Oximetry, Optical components, Mammography, Imaging spectroscopy, Functional imaging

Read Abstract +

Proceedings Article | 30 March 2020 Presentation

Chromatic aberration-based phase and fluorescence microscope for cell cycle study (Conference Presentation)

Ondrej Mandula, Jean-Philippe Kleman, Francoise Lacroix, Dainel Fiole, Cédric Allier, Lionel Hervé, Sophie Morales

Proceedings Volume 11351, 113510O (2020) https://doi.org/10.1117/12.2555434

Read Abstract +

We designed a particularly simple, compact and robust microscope for phase and fluorescent imaging. The phase-contrast image is reconstructed from a single, approximately 100 µm defocused image with an algorithm based on a constrained optimization of Fresnel diffraction model. Fluorescence image is recorded in-focus. No mechanical movement of neither sample nor objective or any other part of the system is needed to change between the phase-contrast and fluorescence modality. The change of focus between phase (out-of-focus) and fluorescence (in-focus) imaging is achieved with chromatic aberration specifically enhanced by the optical design of our system. Our microscope is sufficiently compact (10x10x10 cm^3) to fit into a standard biological incubator. The simple and robust design reduces the vibration and the drift of the sample. The absence of motorized components makes the system robust and resistant to the humid conditions inside the biological incubator. These aspects greatly facilitate the long-time observation of cell cultures. We can observe a thousand of cells in parallel in a single field of view (1mm^2) with resolution down to 2 µm. We show FUCCI marked HeLa cell culture observed over three days directly in the incubator. FUCCI (fluorescence ubiquitination cell-cycle indicator), is a genetically encoded, two-colour (red and green), indicator of the progression through the cell cycle: the cells in G1 phase show red fluorescence nuclei while the cells in S, G2 and M phase display green fluorescence within the nuclei. We use phase images for segmentation and tracking of the individual cells which allows us to determine the level of fluorescence in each cell in the green and red fluorescence channel. We compare the obtained statistics with the data from flow cytometer acquired at the end of the observation. We show that we can produce a statistically relevant time-resolved measurement of a cell population while keeping access to the individual cells.

Proceedings Article | 30 March 2020 Presentation

Video lens-free microscopy of human cells: from standard 2D to 3D organoids culture (Conference Presentation)

Cédric Allier, Sophie Morel, Anthony Berdeu, Lionel Hervé, Thomas Bordy, Michel Bornens, Sabine Bardin, Xavier Gidrol, Nathalie Picollet-D'hahan, Sophie Morales

Proceedings Volume 11351, 113510N (2020) https://doi.org/10.1117/12.2555777

Read Abstract +

Proceedings Article | 30 March 2020 Presentation

Alternation of inverse problem and deep learning approaches for phase retrieval with lens-free microscopy (Conference Presentation)

Cédric Allier, Lionel Hervé, Olivier Cioni, Dorothee Kraemer, Ondrej Mandula, Mathilde Menneteau, Sophie Morales

Proceedings Volume 11351, 113510U (2020) https://doi.org/10.1117/12.2555746

Read Abstract +

Proceedings Article | 11 March 2020 Presentation

Alternation of inverse problem and deep learning approaches for phase unwrapping in lens-free microscopy (Conference Presentation)

Cédric Allier, Lionel Hervé, Dorothée Kraemer, Olivier Cioni, Mathilde Menneteau, Ondrej Mandula, Sophie Morales

Proceedings Volume 11249, 1124914 (2020) https://doi.org/10.1117/12.2544812

KEYWORDS: Inverse problems, Microscopy, Image restoration, Neural networks, Diffraction, Image processing, Phase retrieval, Data processing

Read Abstract +

Proceedings Article | 9 March 2020 Presentation

A simple, compact and robust phase and fluorescence microscope for cell cycle study (Conference Presentation)

Ondrej Mandula, Cedric Allier, Dainel Fiole, Jean-Philippe Kleman, Francoise Lacroix, Lionel Hervé, Sophie Morales

Proceedings Volume 11243, 112430P (2020) https://doi.org/10.1117/12.2543764

KEYWORDS: Luminescence, Microscopes, Image segmentation, Chromatic aberrations

Read Abstract +

Proceedings Article | 22 July 2019 Paper

Deep-learning for phase unwrapping in lens-free imaging

L. Hervé, C. Allier, O. Cioni, F. Navarro, M. Menneteau, S. Morales

Proceedings Volume 11076, 1107610 (2019) https://doi.org/10.1117/12.2527004

KEYWORDS: Diffraction, Reconstruction algorithms, Neurons, Video, Inverse optics, Convolutional neural networks, Microscopes, Microscopy, Inverse problems, CMOS sensors

Read Abstract +

Proceedings Article | 11 July 2019 Paper

The BITMAP exercise: a multi-laboratory performance assessment campaign of diffuse optical instrumentation

Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Lionel Hervé, Turgut Durduran, Adam Liebert, Piotr Sawosz, Antonio Belli, Ilias Tachtsidis, Alberto Dalla Mora, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11074, 110741A (2019) https://doi.org/10.1117/12.2527120

KEYWORDS: Optical instrument design, Spectroscopy, Oximeters, Standards development, Biomedical engineering, Diffuse optical imaging, Absorption, Scattering

Read Abstract +

Proceedings Article | 11 July 2019 Paper

The BitMap dataset: an open dataset on performance assessment of diffuse optics instruments

David Orive-Miguel, Pranav Lanka, Lin Yang, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Joshua Deepak Veesa, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Lionel Hervé, Turgut Durduran, Adam Liebert, Piotr Sawosz, Antonio Belli, Ilias Tachtsidis, Alberto Dalla Mora, Jérôme Mars, Laurent Condat, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11074, 110741B (2019) https://doi.org/10.1117/12.2526728

KEYWORDS: Diffuse optical imaging, Spectrometers, Oximeters, Transparency, Standards development, Biomedical engineering

Read Abstract +

Proceedings Article | 11 July 2019 Paper

Time-resolved diffuse optical tomography: a novel method to compute datatypes allows better absorption quantification

David Orive-Miguel, Lionel Hervé, Jérôme Mars, Laurent Condat, Pierre Jallon

Proceedings Volume 11074, 1107409 (2019) https://doi.org/10.1117/12.2526775

KEYWORDS: Absorption, Diffuse optical tomography, Optical properties, Inverse problems, Imaging spectroscopy, 3D modeling, Diffusion, Computer simulations, Fourier transforms

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Quantitative phase imaging of adherent mammalian cells: a comparison of three different techniques (Conference Presentation)

Cédric Allier, Julien Savatier, Serge Monneret, Yves Usson, Lionel Hervé, Ondrej Mandula, Pierre Blandin, Sophie Morales

Proceedings Volume 10887, 108870C (2019) https://doi.org/10.1117/12.2508421

KEYWORDS: Phase imaging, Image processing, Digital holography, Microscopy, Statistical analysis, Microfluidics, Resonators, Profiling, Holographic interferometry, Holography

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Surprisingly simple and compact microscope for time-lapse phase and fluorescence imaging based on chromatic aberration (Conference Presentation)

Ondrej Mandula, Cédric Allier, Lionel Herve, Jean-Philippe Kleman, Francoise Lacroix, Anne Fourest-Lieuvin, Angelique Vinit, Sophie Morales

Proceedings Volume 10887, 108870B (2019) https://doi.org/10.1117/12.2509375

KEYWORDS: Luminescence, Microscopes, Chromatic aberrations, Phase imaging, CMOS cameras, Imaging systems, Spatial resolution, Biological research

Read Abstract +

Proceedings Article | 23 February 2018 Paper

Dynamic quantitative analysis of adherent cell cultures by means of lens-free video microscopy

C. Allier, R. Vincent, F. Navarro, M. Menneteau, L. Ghenim, X. Gidrol, T. Bordy, L. Hervé, O. Cioni, S. Bardin, M. Bornens, Y. Usson, S. Morales

Proceedings Volume 10503, 105031R (2018) https://doi.org/10.1117/12.2289525

KEYWORDS: Video microscopy, Digital holography, Microscopy, Reconstruction algorithms, Quantitative analysis

Read Abstract +

Proceedings Article | 23 February 2018 Paper

Phase from defocus

Ondrej Mandula, Cédric Allier, Lionel Hervé, Eric Denarier, Anne Fourest-Lieuvin, Sylvie Gory-Fauré, Angélique Vinit, Sophie Morales

Proceedings Volume 10503, 105031Q (2018) https://doi.org/10.1117/12.2287693

KEYWORDS: Neurons, Microscopes, Video, Phase imaging, Cameras, Data acquisition, Reconstruction algorithms, Image quality standards, Image quality, Image processing

Read Abstract +

Proceedings Article | 20 February 2018 Presentation + Paper

Label-free cell viability assay using lens-free microscopy

C. Allier, T. Bordy, L. Hervé, O. Cioni, G. Esteban, M. Pisaneschi, S. Morales

Proceedings Volume 10497, 104970B (2018) https://doi.org/10.1117/12.2289811

KEYWORDS: Microscopy, Holography, 3D image reconstruction, Statistical analysis, CMOS sensors, Microscopes

Read Abstract +

Proceedings Article | 20 February 2018 Paper

Lens-free microscopy of cerebrospinal fluid for the laboratory diagnosis of meningitis

Robin Delacroix, Sophie Nhu An Morel, Lionel Hervé, Thomas Bordy, Pierre Blandin, Jean-Marc Dinten, Michel Drancourt, Cédric Allier

Proceedings Volume 10510, 105100K (2018) https://doi.org/10.1117/12.2289539

KEYWORDS: Microscopy, Microfluidics, Microscopes, Point-of-care devices

Read Abstract +

Proceedings Article | 28 July 2017 Paper

Performance evaluation of time-domain multispectral diffuse optical tomography in the reflection geometry

Judy Zouaoui, Laura Di Sieno, David Orive-Miguel, Lionel Hervé, Antonio Pifferi, Andrea Farina, Alberto Dalla Mora, Jacques Derouard, Jérôme Mars, Laurent Condat, Jean-Marc Dinten

Proceedings Volume 10412, 1041208 (2017) https://doi.org/10.1117/12.2285811

KEYWORDS: Diffuse optical tomography, Tomography, Image restoration, Photon counting, Photodetectors

Read Abstract +

Proceedings Article | 6 April 2016 Presentation + Paper

Whole slide imaging of unstained tissue using lensfree microscopy

Sophie Nhu An Morel, Lionel Hervé, Thomas Bordy, Olivier Cioni, Antoine Delon, Catherine Fromentin, Jean-Marc Dinten, Cédric Allier

Proceedings Volume 9711, 97111L (2016) https://doi.org/10.1117/12.2210831

KEYWORDS: Tissues, Holograms, Digital imaging, Microscopy, Pathology, Holography, RGB color model, Sensors, Colon, Biopsy

Read Abstract +

SPIE Journal Paper | 2 February 2016 Open Access

Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats

Georges Bettega, Laura Di Sieno, Marion Aribert, Michel Berger, Cynthia Hamou, Alberto Dalla Mora, Agathe Puszka, Henri Grateau, Davide Contini, Lionel Hervé, Jean-Luc Coll, Jean-Marc Dinten, Antonio Pifferi, Anne Planat-Chrétien

JBO, Vol. 21, Issue 02, 025004, (February 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.2.025004

KEYWORDS: Surgery, Diffuse optical tomography, Veins, Optical fibers, Tomography, Tissues, Skin, Blood, Doppler tomography, 3D acquisition

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 7 October 2015 Open Access

Laser line illumination scheme allowing the reduction of background signal and the correction of absorption heterogeneities effects for fluorescence reflectance imaging

Frederic Fantoni, Lionel Hervé, Vincent Poher, Sylvain Gioux, Jérôme Mars, Jean-Marc Dinten

JBO, Vol. 20, Issue 10, 106003, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.106003

KEYWORDS: Luminescence, Absorption, Signal detection, Capillaries, Reflectivity, Image resolution, Optical properties, Resolution enhancement technologies, Optical filters, Monte Carlo methods

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 16 July 2015 Paper

In-depth quantification by using multispectral time-resolved diffuse optical tomography

Judy Zouaoui, Lionel Hervé, Laura Di Sieno, Anne Planat-Chrétien, Michel Berger, Alberto Dalla Mora, Antonio Pifferi, Jacques Derouard, Jean-Marc Dinten

Proceedings Volume 9538, 95380C (2015) https://doi.org/10.1117/12.2183819

KEYWORDS: Chromophores, Diffuse optical tomography, Absorption, Photons, Optical fibers, Tissues, Sensors, Transform theory, Light, Liquids

Read Abstract +

Proceedings Article | 16 July 2015 Paper

Time resolved optical detection for white matter lesion detection: preclinical tests on macaque brains and MRI co-registration

A. Planat-Chrétien, M. Berger, L. Hervé, L. Watroba, J. Demilly, J. Flament, L. Stimmer, P. Aubourg, J.-M. Dinten

Proceedings Volume 9538, 953806 (2015) https://doi.org/10.1117/12.2183733

KEYWORDS: Magnetic resonance imaging, Brain, Absorption, Data acquisition, Geometrical optics, 3D modeling, Optical testing, Tissues, Surgery, Electronic filtering

Read Abstract +

Proceedings Article | 16 July 2015 Paper

Lensfree video microscopy: high throughput monitoring and cell tracking of 2D cell cultures

C. Allier, S. Vinjimore Kesavan, O. Cioni, F. Momey, T. Bordy, L. Hervé, S. Morel, F. Navarro, M. Menneteau, B. Chalmond, D. Freida, E. Sulpice, X. Gidrol, J.-M. Dinten

Proceedings Volume 9536, 95360J (2015) https://doi.org/10.1117/12.2183468

KEYWORDS: Detection and tracking algorithms, Video microscopy, Video, Image segmentation, Microscopes, Signal to noise ratio, Holography, Cell death, Time metrology, Reconstruction algorithms

Read Abstract +

Proceedings Article | 16 July 2015 Paper

Time-resolved diffuse optical tomography for non-invasive flap viability assessment: pre-clinical tests on rats

L. Di Sieno, G. Bettega, M. Berger, C. Hamou, M. Aribert, A. Dalla Mora, A. Puszka, H. Grateau, D. Contini, L. Hervé, J.-L. Coll, J.-M. Dinten, A. Pifferi, A. Planat-Chrétien

Proceedings Volume 9538, 95380N (2015) https://doi.org/10.1117/12.2183425

KEYWORDS: Tissues, Veins, Photons, Diffuse optical tomography, Surgery, Neodymium, Arteries, Optical fibers, Sensors, Spatial resolution

Read Abstract +

Proceedings Article | 14 July 2015 Paper

Wide-field lensfree imaging of tissue slides

Sophie Nhu An Morel, Antoine Delon, Pierre Blandin, Thomas Bordy, Olivier Cioni, Lionel Hervé, Catherine Fromentin, Jean-Marc Dinten, Cédric Allier

Proceedings Volume 9536, 95360K (2015) https://doi.org/10.1117/12.2183462

KEYWORDS: Tissues, Holograms, Microscopes, Sensors, Reconstruction algorithms, Image retrieval, 3D image reconstruction, Image resolution, Biopsy, Optical filters

Read Abstract +

SPIE Journal Paper | 14 November 2014 Open Access

Depth-enhanced fluorescence imaging using masked detection of structured illumination

Joseph Angelo, Vivek Venugopal, Frederic Fantoni, Vincent Poher, Irving Bigio, Lionel Hervé, Jean-Marc Dinten, Sylvain Gioux

JBO, Vol. 19, Issue 11, 116008, (November 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.116008

KEYWORDS: Luminescence, Mirrors, Photons, Collimation, Tissues, Point spread functions, Cameras, Relays, CCD cameras, Real time imaging

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 1 October 2014 Open Access

Laser line scanning for fluorescence reflectance imaging: a phantom study and in vivo validation of the enhancement of contrast and resolution

Frederic Fantoni, Lionel Hervé, Vincent Poher, Sylvain Gioux, Jérôme Mars, Jean-Marc Dinten

JBO, Vol. 19, Issue 10, 106003, (October 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.10.106003

KEYWORDS: Luminescence, Signal detection, Reflectivity, In vivo imaging, Image resolution, Capillaries, Resolution enhancement technologies, Photons, Absorption, Optical filters

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 4 March 2014 Paper

Multi-wavelength and time-domain diffuse optical tomography data processing by using a material basis and Mellin-Laplace transform

Lionel Hervé, Anne Planat-Chrétien, Laura Di Sieno, Michel Berger, Agathe Puszka, Alberto Dalla Mora, Davide Contini, Gianluca Boso, Jean-Marc Dinten

Proceedings Volume 8952, 89520D (2014) https://doi.org/10.1117/12.2039506

KEYWORDS: Absorption, Photons, Sensors, Optical tomography, Oxygen, Chromophores, 3D modeling, Tissues, Data processing, Picosecond phenomena

Read Abstract +

Proceedings Article | 27 February 2014 Paper

Background fluorescence reduction and absorption correction for fluorescence reflectance imaging

F. Fantoni, L. Hervé, V. Poher, S. Gioux, J. Mars, J. M. Dinten

Proceedings Volume 8935, 89350Z (2014) https://doi.org/10.1117/12.2037600

KEYWORDS: Absorption, Luminescence, Signal detection, Monte Carlo methods, Capillaries, Liquids, Tissues, Molecular imaging, Sensors, Tissue optics

Read Abstract +

Proceedings Article | 17 February 2014 Paper

Optimal arrangements of fiber optic probes to enhance the spatial resolution in depth for 3D reflectance diffuse optical tomography with time-resolved measurements performed with fast-gated single-photon avalanche diodes

Agathe Puszka, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Davide Contini, Gianluca Boso, Alberto Tosi, Lionel Hervé, Anne Planat-Chrétien, Anne Koenig, Jean-Marc Dinten

Proceedings Volume 8937, 89370Z (2014) https://doi.org/10.1117/12.2036351

KEYWORDS: Spatial resolution, Sensors, Fiber optics, Diffuse optical tomography, Avalanche photodiodes, 3D metrology, Reflectivity, Photons, Fiber optics tests, Liquids

Read Abstract +

Proceedings Article | 17 February 2014 Paper

Time-resolved measurements in diffuse reflectance: effects of the instrument response function of different detection systems on the depth sensitivity

Agathe Puszka, Anne Planat-Chrétien, Michel Berger, Lionel Hervé, Jean-Marc Dinten

Proceedings Volume 8937, 893710 (2014) https://doi.org/10.1117/12.2036366

KEYWORDS: High power microwaves, Photons, Sensors, 3D metrology, Cameras, Single photon detectors, 3D image reconstruction, Imaging systems, Reflectivity, Photomultipliers

Read Abstract +

Proceedings Article | 14 June 2013 Paper

Experimental results on time-resolved reflectance diffuse optical tomography with fast-gated SPADs

Agathe Puszka, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Davide Contini, Gianluca Boso, Alberto Tosi, Anne Planat-Chrétien, Lionel Hervé, Anne Koenig, Jean-Marc Dinten

Proceedings Volume 8799, 879903 (2013) https://doi.org/10.1117/12.2033275

KEYWORDS: Reflectivity, Sensors, Diffuse optical tomography, Reconstruction algorithms, Detection and tracking algorithms, Avalanche photodiodes, Tissue optics, Biomedical optics, Image restoration, Photon counting

Read Abstract +

Proceedings Article | 14 June 2013 Paper

Detection and localization in depth with TR-DOT based on Mellin Laplace transforms

Anne Planat-Chrétien, Lionel Hervé, Michel Berger, Agathe Puszka, Jean-Marc Dinten

Proceedings Volume 8799, 87990A (2013) https://doi.org/10.1117/12.2032576

KEYWORDS: Transform theory, Absorption, Brain, Photons, Diffusion, Sensors, Biomedical optics, Reflectivity, Imaging systems, Brain mapping

Read Abstract +

Proceedings Article | 25 March 2013 Paper

Design of an optimized time-resolved diffuse optical tomography probe to achieve deep absorption contrast reconstruction in a cylindrical geometry

Anne Planat-Chrétien, Lionel Hervé, Michel Berger, Agathe Puszka, Jean-Marc Dinten

Proceedings Volume 8578, 857826 (2013) https://doi.org/10.1117/12.2003549

KEYWORDS: Absorption, Diffusion, Photons, Optical fibers, Sensors, Diffuse optical tomography, 3D modeling, Femtosecond phenomena, Head, CCD cameras

Read Abstract +

Proceedings Article | 25 March 2013 Paper

Masked detection of structured illumination (MDSI): depth sensitive fluorescence measurement

Joseph Angelo, Vivek Venugopal, Frederic Fantoni, Irving Bigio, Lionel Herve, Jean-Marc Dinten, Vincent Poher, Sylvain Gioux

Proceedings Volume 8578, 85780Q (2013) https://doi.org/10.1117/12.2004645

KEYWORDS: Luminescence, Point spread functions, Composites, Mirrors, Cameras, Image processing, CCD cameras, Image restoration, Collimation, Integrated optics

Read Abstract +

Proceedings Article | 25 March 2013 Paper

Fluorescence tomography applied to prostate cancer diagnosis using white pulsed laser

A. Daures, J. Boutet, L. Hervé, R. Sauze, A. Puszka, E. Heinrich, N. Grenier, J. M. Dinten

Proceedings Volume 8578, 85781R (2013) https://doi.org/10.1117/12.2003924

KEYWORDS: Luminescence, Prostate, Diffusion, Optical filters, Signal detection, Pulsed laser operation, Ultrasonography, Biopsy, Fluorescence tomography, Prostate cancer

Read Abstract +

Proceedings Article | 22 March 2013 Paper

Laser line scanning illumination scheme for the enhancement of contrast and resolution for fluorescence reflectance imaging

F. Fantoni, L. Hervé, V. Poher, S. Gioux, J. Mars, J. Dinten

Proceedings Volume 8572, 85720L (2013) https://doi.org/10.1117/12.2004320

KEYWORDS: Signal detection, Luminescence, Tissues, Image processing, Image resolution, Liquids, Tissue optics, Molecular imaging, Reflectivity, Mirrors

Read Abstract +

Proceedings Article | 15 June 2011 Paper

Toward absolute quantification in CW-FDOT systems: use of a priori information

Anne Planat-Chrétien, Anne Koenig, Jean-Guillaume Coutard, Lionel Hervé, Marco Brambilla, Jean-Marc Dinten

Proceedings Volume 8088, 80880W (2011) https://doi.org/10.1117/12.889583

KEYWORDS: Diffusion, Luminescence, Reconstruction algorithms, Geometrical optics, Skin, Diffuse optical tomography, Tumors, Tissue optics, 3D acquisition, Calibration

Read Abstract +

Proceedings Article | 9 June 2011 Paper

Lensfree in-line holographic detection of bacteria

V. Poher, C. Allier, J. Coutard, L. Hervé, J. Dinten

Proceedings Volume 8086, 808619 (2011) https://doi.org/10.1117/12.889324

KEYWORDS: Bacteria, 3D image reconstruction, Thin films, Holograms, Holography, CMOS sensors, Sensors, Microlens, Imaging systems, Signal to noise ratio

Read Abstract +

SPIE Journal Paper | 1 May 2011

Optical tomograph optimized for tumor detection inside highly absorbent organs

Jerome Boutet, Anne Koenig, Lionel Hervé, Michel Berger, Jean-Marc Dinten, Véronique Josserand, Jean-Luc Coll

OE, Vol. 50, Issue 05, 053203, (May 2011) https://doi.org/10.1117/12.10.1117/1.3574768

KEYWORDS: Luminescence, Tumors, Lung, Optical filters, Reconstruction algorithms, Cameras, Glasses, Signal detection, Cancer, Lung cancer

Read Abstract +

Proceedings Article | 1 March 2011 Paper

Time resolved optical system for an early detection of prostate tumor

Lionel Hervé, Aurélie Laidevant, Mathieu Debourdeau, Jérôme Boutet, Jean-Marc Dinten

Proceedings Volume 7896, 789622 (2011) https://doi.org/10.1117/12.874575

KEYWORDS: Luminescence, Optical fibers, Prostate, Tumors, Sensors, Light, Diffusion, Signal detection, Phase modulation, Ultrasonography

Read Abstract +

Proceedings Article | 17 February 2011 Paper

Multisite and multidepth tumors localization enhancement after autofluorescence removal

Anne-Sophie Montcuquet, Lionel Hervé, Fabrice Navarro, Jean-Marc Dinten, Jérôme Mars

Proceedings Volume 7896, 78962S (2011) https://doi.org/10.1117/12.874594

KEYWORDS: Tumors, Luminescence, Tissues, Signal detection, Spectroscopy, Fluorescence spectroscopy, In vivo imaging, Fluorescent markers, Matrices, Capillaries

Read Abstract +

Proceedings Article | 17 February 2011 Paper

Near-infrared pulsed light to guide prostate biopsy

J. Boutet, M. Debourdeau, A. Laidevant, L. Hervé, C. Allié, D. Vray, J.-M. Dinten

Proceedings Volume 7895, 78950N (2011) https://doi.org/10.1117/12.874631

KEYWORDS: Prostate, Ultrasonography, Biopsy, Luminescence, Optical fibers, Fiber lasers, Tumors, Signal detection, Tissues, Optical testing

Read Abstract +

Proceedings Article | 10 February 2011 Paper

Potentialities of a new bimodal Xray/fluorescence tomograph within a cyindrical geometry for pre-clinical studies

Anne Koenig, Anne Planat-Chrétien, Jean-Guillaume Coutard, Lionel Hervé, Marco Brambilla, Véronique Josserand, Jean-Luc Coll, Jean-Marc Dinten

Proceedings Volume 7892, 78920J (2011) https://doi.org/10.1117/12.874453

KEYWORDS: Luminescence, X-rays, Lung, X-ray optics, Capillaries, Reconstruction algorithms, Abdomen, Signal detection, Diffuse optical tomography, Tumors

Read Abstract +

SPIE Journal Paper | 1 September 2010 Open Access

Nonnegative matrix factorization: a blind spectra separation method for in vivo fluorescent optical imaging

Anne-Sophie Montcuquet, Lionel Hervé, Fabrice Navarro Y Garcia, Jean-Marc Dinten, Jérôme Mars

JBO, Vol. 15, Issue 05, 056009, (September 2010) https://doi.org/10.1117/12.10.1117/1.3491796

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 2 March 2010 Paper

Comparison between two time-resolved approaches for prostate cancer diagnosis: high rate imager vs. photon counting system

J. Boutet, M. Debourdeau, A. Laidevant, L. Hervé, J.-M. Dinten

Proceedings Volume 7548, 75481A (2010) https://doi.org/10.1117/12.841125

KEYWORDS: Optical fibers, Luminescence, Imaging systems, Photon counting, Ultrasonography, Prostate, Sensors, Signal detection, Prostate cancer, Temporal resolution

Read Abstract +

Proceedings Article | 26 February 2010 Paper

Non-negative matrix factorization: a blind sources separation method applied to optical fluorescence spectroscopy and multiplexing

Anne-Sophie Montcuquet, Lionel Hervé, Jean-Marc Dinten, Jérôme Mars

Proceedings Volume 7573, 757314 (2010) https://doi.org/10.1117/12.840648

KEYWORDS: Luminescence, Optical phantoms, Multiplexing, Fluorescent markers, Fluorescence spectroscopy, Spectroscopy, Matrices, Tissues, Diffuse optical tomography, Capillaries

Read Abstract +

Proceedings Article | 24 February 2010 Paper

Regularization in fluorescence diffuse optical tomography using prior information on the medium optical properties

E. Péry, L. Hervé, J. Dinten, F. Peyrin

Proceedings Volume 7557, 75570V (2010) https://doi.org/10.1117/12.841368

KEYWORDS: Luminescence, Optical properties, Diffuse optical tomography, Reconstruction algorithms, Geometrical optics, Tissue optics, Sensors, Signal detection, Optical testing, Light

Read Abstract +

Proceedings Article | 24 February 2010 Paper

Localization of fluorescence marked prostate tumor with time-resolved diffuse optical tomography

Lionel Hervé, Aurélie Laidevant, Ludovic Lecordier, Laurent Guyon, Mathieu Debourdeau, Jérôme Boutet, Jean-Marc Dinten

Proceedings Volume 7557, 75570F (2010) https://doi.org/10.1117/12.840861

KEYWORDS: Luminescence, Optical fibers, Prostate, Tumors, Sensors, Ultrasonography, Reconstruction algorithms, Light, Diffusion, Electronic filtering

Read Abstract +

Proceedings Article | 24 February 2010 Paper

Development of a bi-modality XCT: fDOT instrument

Anne Koenig, Anne Planat-Chrétien, Jean-Guillaume Coutard, Lionel Hervé, Ludovic Lecordier, Marco Brambilla, Jean-Marc Dinten

Proceedings Volume 7557, 755709 (2010) https://doi.org/10.1117/12.840374

KEYWORDS: Luminescence, X-rays, X-ray optics, Reconstruction algorithms, Diffuse optical tomography, X-ray fluorescence spectroscopy, Diffusion, Optical tomography, Tomography, Capillaries

Read Abstract +

SPIE Journal Paper | 1 January 2010 Open Access

Fluorescence diffuse optical tomography for free-space and multifluorophore studies

Anne Koenig, Lionel Hervé, Georges Gonon, Véronique Josserand, Michel Berger, Jean-Marc Dinten, Jerome Boutet, Philippe Peltié, Jean-Luc Coll, Philippe Rizo

JBO, Vol. 15, Issue 01, 016016, (January 2010) https://doi.org/10.1117/12.10.1117/1.3309738

KEYWORDS: Luminescence, Optical filters, Bandpass filters, Diffuse optical tomography, Capillaries, Glasses, In vivo imaging, Image filtering, Tumors, Reconstruction algorithms

Read Abstract +

DOWNLOAD PAPER

SPIE Journal Paper | 1 November 2009 Open Access

Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis

Jerome Boutet, Lionel Hervé, Mathieu Debourdeau, Laurent Guyon, Philippe Peltie, Jean-Marc Dinten, Laurent Saroul, Francois Duboeuf, Didier Vray

JBO, Vol. 14, Issue 06, 064001, (November 2009) https://doi.org/10.1117/12.10.1117/1.3257236

KEYWORDS: Luminescence, Ultrasonography, Prostate, Tissues, Prostate cancer, Signal detection, Tumors, Sensors, Absorption, Capillaries

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 10 July 2009 Paper

Mice lung disease follow-up with open-air fluorescence diffuse optical tomography

Anne Koenig, Georges Gonon, Lionel Hervé, Michel Berger, Jean-Marc Dinten, Jérôme Boutet, Véronique Josserand, Jean-Luc Coll, Philippe Peltié, Philippe Rizo

Proceedings Volume 7369, 73690U (2009) https://doi.org/10.1117/12.831697

KEYWORDS: Luminescence, Free space, Lung, Tumors, Cameras, Diffuse optical tomography, Imaging systems, Reconstruction algorithms, Geometrical optics, In vivo imaging

Read Abstract +

Proceedings Article | 12 February 2009 Paper

Time-resolved fluorescence tomography in cancer research: backward versus toward geometry

Laurent Guyon, Lionel Hervé, Jérome Boutet, Mathieu Debourdeau, Nadia Djaker, Anabela da Silva, Philippe Peltié, Jean-Marc Dinten, Philippe Rizo

Proceedings Volume 7174, 71741X (2009) https://doi.org/10.1117/12.808237

KEYWORDS: Luminescence, Sensors, Diffusion, Breast, Cancer, Liquids, Signal detection, Tomography, Diffuse optical tomography, Optical properties

Read Abstract +

SPIE Journal Paper | 1 January 2008 Open Access

In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography

Anne Koeing, Lionel Herve, Véronique Josserand, Michel Berger, Jérôme Boutet, Anabela Da Silva, Jean-Marc Dinten, Philippe Peltie, Jean-Luc Coll, Philippe Rizo

JBO, Vol. 13, Issue 01, 011008, (January 2008) https://doi.org/10.1117/12.10.1117/1.2884505

KEYWORDS: Luminescence, Lung, Tumors, In vivo imaging, Capillaries, Cancer, Glasses, Reconstruction algorithms, Inspection, 3D modeling

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 12 July 2007 Paper

fDOT for in vivo follow-up of tumor development in mice lungs

Anne Koenig, Lionel Hervé, Anabela Da Silva, Jean-Marc Dinten, Jérôme Boutet, Michel Berger, Véronique Josserand, Jean-Luc Coll, Philippe Peltié, Philippe Rizo

Proceedings Volume 6629, 662915 (2007) https://doi.org/10.1117/12.727862

KEYWORDS: Luminescence, Tumors, Lung, 3D modeling, In vivo imaging, Geometrical optics, Reconstruction algorithms, Animal model studies, Liquids, Glasses

Read Abstract +

Proceedings Article | 13 February 2007 Paper

In vivo fluorescence enhanced optical tomography reconstruction of lung cancer of non immersed small animals

L. Hervé, A. Koenig, A. Da Silva, M. Berger, J. Boutet, J. Dinten, P. Peltié, P. Rizo

Proceedings Volume 6434, 643410 (2007) https://doi.org/10.1117/12.700337

KEYWORDS: Luminescence, Cancer, In vivo imaging, Sensors, Geometrical optics, Signal detection, Lung cancer, Tissue optics, Optical tomography, CCD cameras

Read Abstract +

Proceedings Article | 2 March 2006 Paper

Performance of different reflectance and diffuse optical imaging tomographic approaches in fluorescence molecular imaging of small animals

Jean-Marc Dinten, Philippe Petié, Anabela da Silva, Jérôme Boutet, Anne Koenig, Lionel Hervé, Michel Berger, Aurélie Laidevant, Philippe Rizo

Proceedings Volume 6142, 614215 (2006) https://doi.org/10.1117/12.647494

KEYWORDS: Luminescence, Reflectivity, Imaging systems, Tissues, Diffuse optical imaging, Tomography, Liquids, Reconstruction algorithms, Fluorescent markers, Diffusion

Read Abstract +

Proceedings Article | 26 November 2002 Paper

Optimization of x-ray spectra for bone mineral density and body composition measurements: theoretical study and experimental validation

Lionel Herve, Christine Robert-Coutant, Jean-Marc Dinten, Loick Verger, Vincent Comparat

Proceedings Volume 4786, (2002) https://doi.org/10.1117/12.451534

KEYWORDS: Sensors, Signal attenuation, Spectroscopy, Bone, X-rays, Minerals, Tissues, Optical filters, Calibration, Densitometry

Read Abstract +

Showing 5 of 69 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years